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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:PAE3091
OrganismiPyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Taxonomic identifieri178306 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367281 – 375Tryptophan--tRNA ligaseAdd BLAST375

Proteomic databases

PRIDEiQ8ZTU5

Interactioni

Protein-protein interaction databases

STRINGi178306.PAE3091

Structurei

3D structure databases

ProteinModelPortaliQ8ZTU5
SMRiQ8ZTU5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi81 – 89"HIGH" region9
Motifi258 – 262"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01887 Archaea
COG0180 LUCA
HOGENOMiHOG000224742
InParanoidiQ8ZTU5
KOiK01867
OMAiADILHPQ
OrthoDBiPOG093Z034D

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00140_A Trp_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR020653 Tryptophan-tRNA-ligase_arc
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZTU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEEFVVTPW EVRGRVDYEK LLKHFGAKPL TKDEVALLEK YAGEVHPLIR
60 70 80 90 100
RGFFYAHRDF DFIMKWHGEG RPWALYTGRG PSGPVHIGHM VPWILLKWFS
110 120 130 140 150
DKFGLEVYFQ ITDDEKFYDD PEMKLEEATN WAYENALDVI ALGFSPERLH
160 170 180 190 200
LIIDTKDIKP LYPIAVRVAK KLTWNTVKAT FGFTDSTNIG LIFYPSLQIA
210 220 230 240 250
VAFLPTELRR EATPVLIPCA IDQDPYFRLA RDIADALGYP KPSTLYSKFI
260 270 280 290 300
MALTGESKMS ASNPDSAIYT LDDEKTVRRK VMNAFTGGRP TAEEQRKYGG
310 320 330 340 350
NPEVCPVFHY HMLFDPDDAS VEKIRQDCKS GALLCGECKL KLHEKITKFL
360 370
KEHRERREKA RGKVDEYRLS VKLSK
Length:375
Mass (Da):43,179
Last modified:March 1, 2002 - v1
Checksum:i3DDBF85DA680F116
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009441 Genomic DNA Translation: AAL64664.1

Genome annotation databases

EnsemblBacteriaiAAL64664; AAL64664; PAE3091
KEGGipai:PAE3091
PATRICifig|178306.9.peg.2323

Similar proteinsi

Entry informationi

Entry nameiSYW_PYRAE
AccessioniPrimary (citable) accession number: Q8ZTU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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