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Protein

S-methyl-5'-thioadenosine phosphorylase

Gene

mtnP

Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.UniRule annotation

Catalytic activityi

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: L-methionine biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. S-methyl-5'-thioadenosine phosphorylase (mtnP)
This subpathway is part of the pathway L-methionine biosynthesis via salvage pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route), the pathway L-methionine biosynthesis via salvage pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei28PhosphateUniRule annotation1
Sitei183Important for substrate specificityUniRule annotation1
Binding sitei202Substrate; via amide nitrogenUniRule annotation1
Binding sitei203PhosphateUniRule annotation1
Sitei238Important for substrate specificityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPurine salvage

Enzyme and pathway databases

UniPathwayiUPA00904; UER00873

Names & Taxonomyi

Protein namesi
Recommended name:
S-methyl-5'-thioadenosine phosphorylaseUniRule annotation (EC:2.4.2.28UniRule annotation)
Alternative name(s):
5'-methylthioadenosine phosphorylaseUniRule annotation
Short name:
MTA phosphorylaseUniRule annotation
Short name:
MTAPUniRule annotation
Gene namesi
Name:mtnPUniRule annotation
Ordered Locus Names:PAE3338
OrganismiPyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Taxonomic identifieri178306 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000002439 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004151061 – 279S-methyl-5'-thioadenosine phosphorylaseAdd BLAST279

Proteomic databases

PRIDEiQ8ZTB2

Interactioni

Subunit structurei

Homohexamer. Dimer of a homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi178306.PAE3338

Structurei

3D structure databases

ProteinModelPortaliQ8ZTB2
SMRiQ8ZTB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni70 – 71Phosphate bindingUniRule annotation2
Regioni103 – 104Phosphate bindingUniRule annotation2
Regioni226 – 228Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01327 Archaea
COG0005 LUCA
HOGENOMiHOG000228987
InParanoidiQ8ZTB2
KOiK00772
OMAiNLYRSWG
OrthoDBiPOG093Z08FG

Family and domain databases

HAMAPiMF_01963 MTAP, 1 hit
InterProiView protein in InterPro
IPR010044 MTAP
IPR000845 Nucleoside_phosphorylase_d
IPR035994 Nucleoside_phosphorylase_sf
PANTHERiPTHR42679 PTHR42679, 1 hit
PfamiView protein in Pfam
PF01048 PNP_UDP_1, 1 hit
SUPFAMiSSF53167 SSF53167, 1 hit
TIGRFAMsiTIGR01694 MTAP, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZTB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKLTNPPKS PKELGFDEFP SIGIIGGSGL YDPGIFENAV EVQIHTPYGL
60 70 80 90 100
PSDNVIVGRV AGRVVAFLPR HGRGHKYPPH KIPYRANIYS LYMLGVRSIV
110 120 130 140 150
AVSAVGSLRP DYAPGDFVVP DQFVDMTKGR EYTFYDGPRT CHIQIGLEPF
160 170 180 190 200
TQEIRQILIE TAKKYNRTHD GGCYVCIEGP RFSTKAESRI WREVFGCDII
210 220 230 240 250
GMTLVPEINL ARELGMCYGL IALVTDYDIW VPHQPVTAEA VEKMMTEKLG
260 270
IIKKVIAEAV PKLPAELPKC SETLKYACV
Length:279
Mass (Da):31,014
Last modified:March 1, 2002 - v1
Checksum:i86D368E1B1CDB7C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009441 Genomic DNA Translation: AAL64851.1

Genome annotation databases

EnsemblBacteriaiAAL64851; AAL64851; PAE3338
KEGGipai:PAE3338
PATRICifig|178306.9.peg.2515

Similar proteinsi

Entry informationi

Entry nameiMTAP_PYRAE
AccessioniPrimary (citable) accession number: Q8ZTB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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