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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligase (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:argS
Ordered Locus Names:PAE3343
OrganismiPyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Taxonomic identifieri178306 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000002439 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001516511 – 630Arginine--tRNA ligaseAdd BLAST630

Proteomic databases

PRIDEiQ8ZTA8.

Interactioni

Protein-protein interaction databases

STRINGi178306.PAE3343.

Structurei

3D structure databases

ProteinModelPortaliQ8ZTA8.
SMRiQ8ZTA8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi120 – 130"HIGH" regionAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.

Phylogenomic databases

eggNOGiarCOG00487. Archaea.
COG0018. LUCA.
HOGENOMiHOG000247213.
InParanoidiQ8ZTA8.
KOiK01887.
OMAiNKPLHLG.
OrthoDBiPOG093Z013U.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth. 1 hit.
InterProiView protein in InterPro
IPR001278. Arg-tRNA-ligase.
IPR035684. ArgRS_core.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiView protein in Pfam
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 2 hits.
PRINTSiPR01038. TRNASYNTHARG.
SMARTiView protein in SMART
SM00836. DALR_1. 1 hit.
SUPFAMiSSF47323. SSF47323. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZTA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPLRQPREE FVKVLGEVSR ELGLPEVPEV ERTRRYGFFS ARFHKYKVDH
60 70 80 90 100
SRLAEVVNLI KNKRFEFLSS LSVDGLYLNA DLNVSKVAEL VFEAVVKMGR
110 120 130 140 150
KYGFTEECVT GSYLVEHTSA NPVHPLHIGH GRNAILGDSL ARLLKFCGNK
160 170 180 190 200
VETHFYVDDC GVQVMYAAMG YNAVKDEVKK RIEKSKPDVV IGHVYSATNA
210 220 230 240 250
VAEIGRLKKE LEKAQDDERK REILREIDEW VAVLKRLMDS EGDIISKIAE
260 270 280 290 300
ELGRRDLLNE AVELNRRYES GDPEAKGVVR EVVDLVLKGQ RETLARLGVE
310 320 330 340 350
IDKWDYESEL TVWSSEAMRI VSELQKRWPQ YIEIKGGAVV FRADKFVQDY
360 370 380 390 400
NLWDVLDLPR FIPPVTLTRS DGTTLYVTRD VAYALWQARQ GFDKVIRVIS
410 420 430 440 450
TEQTHEQAHV RIILYALGYV DEAKKIVHYA YEMVNLPGMK MSARRGQYIS
460 470 480 490 500
LDEILDEAAE RSASLVKEKN PEVSGVIAER VGVGSVRYAF LTTSPRKPIE
510 520 530 540 550
FKWDVVLNLR QNSGTFLQYT YVRAYSILEK AGEIGNVPVP ENMLAEEREL
560 570 580 590 600
VLKIAEWPSV VKEAAKSLRP DYVAEYLDGL ALVFNSYYEK APVLKAEESV
610 620 630
RGFRIAIVNA VKTVLEAGFY ILGIPTLTKM
Length:630
Mass (Da):71,667
Last modified:March 1, 2002 - v1
Checksum:i40A1D80199267641
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009441 Genomic DNA. Translation: AAL64855.1.

Genome annotation databases

EnsemblBacteriaiAAL64855; AAL64855; PAE3343.
KEGGipai:PAE3343.
PATRICifig|178306.9.peg.2519.

Similar proteinsi

Entry informationi

Entry nameiSYR_PYRAE
AccessioniPrimary (citable) accession number: Q8ZTA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 1, 2002
Last modified: November 22, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families