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Q8ZTA8 (SYR_PYRAE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:PAE3343
OrganismPyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827) [Reference proteome] [HAMAP]
Taxonomic identifier178306 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum

Protein attributes

Sequence length630 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 630630Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000151651

Regions

Motif120 – 13011"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q8ZTA8 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 40A1D80199267641

FASTA63071,667
        10         20         30         40         50         60 
MDPLRQPREE FVKVLGEVSR ELGLPEVPEV ERTRRYGFFS ARFHKYKVDH SRLAEVVNLI 

        70         80         90        100        110        120 
KNKRFEFLSS LSVDGLYLNA DLNVSKVAEL VFEAVVKMGR KYGFTEECVT GSYLVEHTSA 

       130        140        150        160        170        180 
NPVHPLHIGH GRNAILGDSL ARLLKFCGNK VETHFYVDDC GVQVMYAAMG YNAVKDEVKK 

       190        200        210        220        230        240 
RIEKSKPDVV IGHVYSATNA VAEIGRLKKE LEKAQDDERK REILREIDEW VAVLKRLMDS 

       250        260        270        280        290        300 
EGDIISKIAE ELGRRDLLNE AVELNRRYES GDPEAKGVVR EVVDLVLKGQ RETLARLGVE 

       310        320        330        340        350        360 
IDKWDYESEL TVWSSEAMRI VSELQKRWPQ YIEIKGGAVV FRADKFVQDY NLWDVLDLPR 

       370        380        390        400        410        420 
FIPPVTLTRS DGTTLYVTRD VAYALWQARQ GFDKVIRVIS TEQTHEQAHV RIILYALGYV 

       430        440        450        460        470        480 
DEAKKIVHYA YEMVNLPGMK MSARRGQYIS LDEILDEAAE RSASLVKEKN PEVSGVIAER 

       490        500        510        520        530        540 
VGVGSVRYAF LTTSPRKPIE FKWDVVLNLR QNSGTFLQYT YVRAYSILEK AGEIGNVPVP 

       550        560        570        580        590        600 
ENMLAEEREL VLKIAEWPSV VKEAAKSLRP DYVAEYLDGL ALVFNSYYEK APVLKAEESV 

       610        620        630 
RGFRIAIVNA VKTVLEAGFY ILGIPTLTKM 

« Hide

References

[1]"Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum."
Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I., Miller J.H.
Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009441 Genomic DNA. Translation: AAL64855.1.
RefSeqNP_560673.1. NC_003364.1.

3D structure databases

ProteinModelPortalQ8ZTA8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING178306.PAE3343.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL64855; AAL64855; PAE3343.
GeneID1464045.
KEGGpai:PAE3343.

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247213.
KOK01887.
OMAVHPLHIG.
ProtClustDBPRK01611.

Enzyme and pathway databases

BioCycPAER178306:GCEO-2452-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001278. Arg-tRNA-ligase.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 2 hits.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYR_PYRAE
AccessionPrimary (citable) accession number: Q8ZTA8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries