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Protein

Putative 2-dehydropantoate 2-reductase

Gene

PAE3409

Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.By similarity

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes (R)-pantoate from 3-methyl-2-oxobutanoate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 3-methyl-2-oxobutanoate hydroxymethyltransferase (panB)
  2. Putative 2-dehydropantoate 2-reductase (PAE3409)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantoate from 3-methyl-2-oxobutanoate, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei86NADP; via amide nitrogenBy similarity1
Binding sitei86SubstrateBy similarity1
Active sitei158Proton donorBy similarity1
Binding sitei162SubstrateBy similarity1
Binding sitei166SubstrateBy similarity1
Binding sitei228SubstrateBy similarity1
Binding sitei240NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6 – 11NADPBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPantothenate biosynthesis
LigandNADP

Enzyme and pathway databases

BioCyciPAER178306:GCEO-2488-MONOMER
UniPathwayiUPA00028; UER00004

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
Ordered Locus Names:PAE3409
OrganismiPyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Taxonomic identifieri178306 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000002439 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001573241 – 279Putative 2-dehydropantoate 2-reductaseAdd BLAST279

Interactioni

Protein-protein interaction databases

STRINGi178306.PAE3409

Structurei

3D structure databases

ProteinModelPortaliQ8ZT70
SMRiQ8ZT70
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ketopantoate reductase family.Curated

Phylogenomic databases

eggNOGiarCOG04139 Archaea
COG1893 LUCA
HOGENOMiHOG000050222
InParanoidiQ8ZT70
KOiK00077
OMAiVACIKGI
OrthoDBiPOG093Z0891

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR003710 ApbA
IPR013752 KPA_reductase
IPR013332 KPR_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02558 ApbA, 1 hit
PF08546 ApbA_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00745 apbA_panE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZT70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRVIGLGAV GSLFTYFLNR AGVVPEVVQR RRCGEFLFCV EGDCEKLKFR
60 70 80 90 100
EGGAADDVGY TIVAVKAYDS RSVVPHLKGV AVVAQNGIGG YEEIKEAYPN
110 120 130 140 150
SVPAVVTYGV YREGCRAELR GVGEIYLPSA VSTLAELLER GGGRVRLVED
160 170 180 190 200
IEPYRWLKLA VNAAINAITA LLQAPNGVII SSPYAQTLAL EVAQEVLNVA
210 220 230 240 250
TALGVKMPRN PVEEVLRVAS ATAKNLSSTA RDVAACAKTE IDYINGAVVK
260 270
YGEALGVATP VNKALFNLIK ARESLCNSG
Length:279
Mass (Da):29,732
Last modified:February 21, 2002 - v1
Checksum:i8A0A50DA29CD1328
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009441 Genomic DNA Translation: AAL64893.1

Genome annotation databases

EnsemblBacteriaiAAL64893; AAL64893; PAE3409
KEGGipai:PAE3409
PATRICifig|178306.9.peg.2562

Similar proteinsi

Entry informationi

Entry nameiPANE_PYRAE
AccessioniPrimary (citable) accession number: Q8ZT70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: February 21, 2002
Last modified: March 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health