Reviewed, UniProtKB/Swiss-Prot Q8ZSY4 (SURE2_PYRAE)

Names and origin

Protein names

Recommended name:
    5'-nucleotidase surE2
    EC=3.1.3.5
Alternative name(s):
    Nucleoside 5'-monophosphate phosphohydrolase 2

Gene names

Name:	surE2
Ordered Locus Names:	PAE3523

Organism

Pyrobaculum aerophilum [Complete proteome] [HAMAP]

Taxonomic identifier

13773 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Thermoproteales › Thermoproteaceae › Pyrobaculum

Protein attributes

Sequence length	249 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity.
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the surE nucleotidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 249	249	5'-nucleotidase surE2 HAMAP MF_00060		PRO_0000111870
Sites
	Metal binding	8	1	Divalent metal cation By similarity
	Metal binding	9	1	Divalent metal cation By similarity
	Metal binding	40	1	Divalent metal cation By similarity
	Metal binding	90	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8ZSY4-1 [UniParc]. Last modified March 5, 2002. Version 1. Checksum: 79A57CA1EBF4A07B	FASTA	249	26,661
	10 20 30 40 50 60 MKIVVTNDDG PHSPLLEPLV RGLEAVGNEV VVVVPERPRS AAGLARTYHK PLRVRRLGGY 70 80 90 100 110 120 YVVNGFPADA VFLALKLIAP DAELVISGVN VGENIGIEAT YGSGTVGAAL QAGVLGVPSI 130 140 150 160 170 180 AASMEVGGDV DFMIKVVEGA VASARAGLDG VLAVSINIPS VWKGGVYCVR KLARAVYRER 190 200 210 220 230 240 LYEGVDPRGE KYYWRWGPRR SEFEPDTDAY YFYYMRGVTV LGLSESGVAS VENFGRKLGQ LIGAVKVDC

References

[1]

"Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum." Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I., Miller J.H. Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002) [PubMed: 11792869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE009441 Genomic DNA. Translation: AAL64979.1.
RefSeq	NP_560797.1.
3D structure databases
HSSP	HSSP built from PDB template 1L5X based on UniProtKB Q8ZU79.
ModBase	Search...
Genome annotation databases
GeneID	1466113.
GenomeReviews	Gene locus PAE3523 in contig AE009441_GR.
KEGG	pai:PAE3523.
NMPDR	fig|178306.1.peg.2487.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8ZSY4.
OMA	YWRWGPR.
Enzyme and pathway databases
BioCyc	PAER178306:PAE3523-MON.
BRENDA	3.1.3.5. 142830.
Family and domain databases
HAMAP	MF_00060. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
ProDom	PD005378. SurE. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00087. surE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE2_PYRAE

Accession

Primary (citable) accession number: Q8ZSY4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
Last sequence update:	March 5, 2002
Last modified:	November 3, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)