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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.By similarity

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-126-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC:2.7.8.13)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene namesi
Name:mraY
Ordered Locus Names:STM0125
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25PeriplasmicSequence analysisAdd BLAST25
Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Topological domaini47 – 71CytoplasmicSequence analysisAdd BLAST25
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Topological domaini93PeriplasmicSequence analysis1
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Topological domaini115 – 131CytoplasmicSequence analysisAdd BLAST17
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Topological domaini153 – 167PeriplasmicSequence analysisAdd BLAST15
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 198CytoplasmicSequence analysis10
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 235PeriplasmicSequence analysisAdd BLAST16
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 262CytoplasmicSequence analysis6
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Topological domaini284 – 287PeriplasmicSequence analysis4
Transmembranei288 – 308HelicalSequence analysisAdd BLAST21
Topological domaini309 – 337CytoplasmicSequence analysisAdd BLAST29
Transmembranei338 – 358HelicalSequence analysisAdd BLAST21
Topological domaini359 – 360PeriplasmicSequence analysis2

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001088851 – 360Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST360

Proteomic databases

PaxDbiQ8ZRU5
PRIDEiQ8ZRU5

Interactioni

Protein-protein interaction databases

STRINGi99287.STM0125

Structurei

3D structure databases

SMRiQ8ZRU5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY Bacteria
COG0472 LUCA
HOGENOMiHOG000275122
KOiK01000
OMAiLMSPLHH
PhylomeDBiQ8ZRU5

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
PF10555 MraY_sig1, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01347 MRAY_1, 1 hit
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZRU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVWLAEHLV KYYSGFNVFS YLTFRAIVSL LTALFISLWM GPRMIARLQK
60 70 80 90 100
LSFGQVVRND GPESHFSKRG TPTMGGIMIL TSIVISVLLW AYPSNPYVWC
110 120 130 140 150
VLVVLIGYGI IGFVDDYRKV VRKDTKGLIA RWKYFWMSVI ALGVAFALYL
160 170 180 190 200
VGKDTPATQL VVPFFKDVMP QLGLFYILLS YFVIVGTGNA VNLTDGLDGL
210 220 230 240 250
AIMPTVFVAA GFALVAWATG NMNFANYLHI PYLRHAGELV IVCTAIVGAG
260 270 280 290 300
LGFLWFNTYP AQVFMGDVGS LALGGALGII AVLLRQEFLL VIMGGVFVVE
310 320 330 340 350
TLSVILQVGS FKLRGQRIFR MAPIHHHYEL KGWPEPRVIV RFWIISLMLV
360
LIGLATLKVR
Length:360
Mass (Da):40,023
Last modified:March 1, 2002 - v1
Checksum:i3DD634C207ACFD94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA Translation: AAL19089.1
RefSeqiNP_459130.1, NC_003197.2
WP_000964141.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL19089; AAL19089; STM0125
GeneIDi1251643
KEGGistm:STM0125
PATRICifig|99287.12.peg.131

Similar proteinsi

Entry informationi

Entry nameiMRAY_SALTY
AccessioniPrimary (citable) accession number: Q8ZRU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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