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Q8ZRS8

- Q8ZRS8_SALTY

UniProt

Q8ZRS8 - Q8ZRS8_SALTY

Protein

Aconitate hydratase 2

Gene

acnB

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O.UniRule annotation
    Citrate = isocitrate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. 2-methylisocitrate dehydratase activity Source: UniProtKB-EC
    2. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    3. aconitate hydratase activity Source: UniProtKB-EC

    GO - Biological processi

    1. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    LyaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    4Fe-4SSAAS annotation, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-13618.
    SENT99287:GCTI-157-MONOMER.
    UniPathwayiUPA00223; UER00718.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aconitate hydratase 2UniRule annotation (EC:4.2.1.3UniRule annotation, EC:4.2.1.99UniRule annotation)
    Alternative name(s):
    2-methylisocitrate dehydrataseUniRule annotation
    Gene namesi
    Name:acnBImported
    Ordered Locus Names:STM0158Imported
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)Imported
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: InterPro

    PTM / Processingi

    Proteomic databases

    PRIDEiQ8ZRS8.

    Interactioni

    Protein-protein interaction databases

    STRINGi99287.STM0158.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8ZRS8.
    SMRiQ8ZRS8. Positions 1-862.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aconitase/IPM isomerase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000205991.
    KOiK01682.
    OMAiYVPNKRA.
    OrthoDBiEOG6N944W.
    PhylomeDBiQ8ZRS8.

    Family and domain databases

    Gene3Di3.20.19.10. 1 hit.
    3.30.499.10. 2 hits.
    3.40.1060.10. 1 hit.
    InterProiIPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
    IPR015937. Acoase/IPM_deHydtase.
    IPR001030. Acoase/IPM_deHydtase_lsu_aba.
    IPR015928. Aconitase/3IPM_dehydase_swvl.
    IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
    IPR018136. Aconitase_4Fe-4S_BS.
    IPR004406. Aconitase_B_bac.
    IPR015933. Aconitase_B_HEAT-like_bac.
    IPR015929. Aconitase_B_N_bac.
    [Graphical view]
    PANTHERiPTHR11670. PTHR11670. 1 hit.
    PfamiPF00330. Aconitase. 2 hits.
    PF06434. Aconitase_2_N. 1 hit.
    PF11791. Aconitase_B_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036687. AcnB. 1 hit.
    SUPFAMiSSF52016. SSF52016. 1 hit.
    SSF53732. SSF53732. 1 hit.
    SSF74778. SSF74778. 1 hit.
    TIGRFAMsiTIGR00117. acnB. 1 hit.
    PROSITEiPS00450. ACONITASE_1. 1 hit.
    PS01244. ACONITASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8ZRS8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLEEYRKHVA ERAAQGIVPK PLDATQMAAL VELLKTPPVG EEEFLLDLLI    50
    NRVPPGVDEA AYVKAGFLAA VAKGDTTSPL VSPEKAIELL GTMQGGYNIH 100
    PLIDALDDAK LAPIAAKALS HTLLMFDNFY DVEEKAKAGN EYAKQVMQSW 150
    ADAEWFLSRP PLAEKITVTV FKVTGETNTD DLSPAPDAWS RPDIPLHAQA 200
    MLKNAREGIE PDQPGVVGPI KQIEALQKKG YPLAYVGDVV GTGSSRKSAT 250
    NSVLWFMGDD IPNVPNKRGG GLCLGGKIAP IFFNTMEDAG ALPIEVDVSN 300
    LNMGDVIDVY PYKGEVRNHE TGELLATFEL KTDVLIDEVR AGGRIPLIIG 350
    RGLTTKAREA LGLPHSDVFR QAKDVAESSR GFSLAQKMVG RACGVKGIRP 400
    GAYCEPKMTS VGSQDTTGPM TRDELKDLAC LGFSADLVMQ SFCHTAAYPK 450
    PVDVTTHHTL PDFIMNRGGV SLRPGDGVIH SWLNRMLLPD TVGTGGDSHT 500
    RFPIGISFPA GSGLVAFAAA TGVMPLDMPE SVLVRFKGKM QPGITLRDLV 550
    HAIPLYAIKQ GLLTVEKKGK KNIFSGRILE IEGLPDLKVE QAFELTDASA 600
    ERSAAGCTIK LNKEPIVEYL TSNIVLLKWM IAEGYGDRRT LERRIQGMEK 650
    WLADPQLLEA DADAEYAAVI DIDLADIKEP ILCAPNDPDD ARLLSDVQGE 700
    KIDEVFIGSC MTNIGHFRAA GKLLDNHKGQ LPTRLWVAPP TRMDAAQLTE 750
    EGYYSVFGKS GARIEIPGCS LCMGNQARVA DGATVVSTST RNFPNRLGTG 800
    ANVFLASAEL AAVAALIGKL PTPEEYQTYV AQVDKTAVDT YRYLNFDQLS 850
    QYTEKADGVI FQTAV 865
    Length:865
    Mass (Da):93,529
    Last modified:March 1, 2002 - v1
    Checksum:iD287309CB026151D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL19122.1.
    RefSeqiNP_459163.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL19122; AAL19122; STM0158.
    GeneIDi1251676.
    KEGGistm:STM0158.
    PATRICi32378597. VBISalEnt20916_0168.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL19122.1 .
    RefSeqi NP_459163.1. NC_003197.1.

    3D structure databases

    ProteinModelPortali Q8ZRS8.
    SMRi Q8ZRS8. Positions 1-862.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM0158.

    Proteomic databases

    PRIDEi Q8ZRS8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL19122 ; AAL19122 ; STM0158 .
    GeneIDi 1251676.
    KEGGi stm:STM0158.
    PATRICi 32378597. VBISalEnt20916_0168.

    Phylogenomic databases

    HOGENOMi HOG000205991.
    KOi K01682.
    OMAi YVPNKRA.
    OrthoDBi EOG6N944W.
    PhylomeDBi Q8ZRS8.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00718 .
    BioCyci MetaCyc:MONOMER-13618.
    SENT99287:GCTI-157-MONOMER.

    Family and domain databases

    Gene3Di 3.20.19.10. 1 hit.
    3.30.499.10. 2 hits.
    3.40.1060.10. 1 hit.
    InterProi IPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
    IPR015937. Acoase/IPM_deHydtase.
    IPR001030. Acoase/IPM_deHydtase_lsu_aba.
    IPR015928. Aconitase/3IPM_dehydase_swvl.
    IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
    IPR018136. Aconitase_4Fe-4S_BS.
    IPR004406. Aconitase_B_bac.
    IPR015933. Aconitase_B_HEAT-like_bac.
    IPR015929. Aconitase_B_N_bac.
    [Graphical view ]
    PANTHERi PTHR11670. PTHR11670. 1 hit.
    Pfami PF00330. Aconitase. 2 hits.
    PF06434. Aconitase_2_N. 1 hit.
    PF11791. Aconitase_B_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036687. AcnB. 1 hit.
    SUPFAMi SSF52016. SSF52016. 1 hit.
    SSF53732. SSF53732. 1 hit.
    SSF74778. SSF74778. 1 hit.
    TIGRFAMsi TIGR00117. acnB. 1 hit.
    PROSITEi PS00450. ACONITASE_1. 1 hit.
    PS01244. ACONITASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720Imported.

    Entry informationi

    Entry nameiQ8ZRS8_SALTY
    AccessioniPrimary (citable) accession number: Q8ZRS8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3