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Q8ZRR1

- PANC_SALTY

UniProt

Q8ZRR1 - PANC_SALTY

Protein

Pantothenate synthetase

Gene

panC

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei37 – 371Proton donorUniRule annotation
    Binding sitei61 – 611Beta-alanineUniRule annotation
    Binding sitei61 – 611PantoateUniRule annotation
    Binding sitei155 – 1551PantoateUniRule annotation
    Binding sitei178 – 1781ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi30 – 378ATPUniRule annotation
    Nucleotide bindingi149 – 1524ATPUniRule annotation
    Nucleotide bindingi186 – 1894ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-180-MONOMER.
    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
    Short name:
    PSUniRule annotation
    Alternative name(s):
    Pantoate--beta-alanine ligaseUniRule annotation
    Pantoate-activating enzymeUniRule annotation
    Gene namesi
    Name:panCUniRule annotation
    Ordered Locus Names:STM0181
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 284284Pantothenate synthetasePRO_0000128266Add
    BLAST

    Proteomic databases

    PaxDbiQ8ZRR1.
    PRIDEiQ8ZRR1.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi99287.STM0181.

    Structurei

    Secondary structure

    1
    284
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2 – 43
    Helixi7 – 1913
    Beta strandi24 – 296
    Helixi35 – 4713
    Beta strandi49 – 557
    Helixi59 – 613
    Helixi65 – 695
    Helixi75 – 8410
    Beta strandi88 – 914
    Helixi95 – 984
    Beta strandi108 – 1103
    Turni112 – 1165
    Helixi118 – 1225
    Helixi126 – 14116
    Beta strandi144 – 1496
    Helixi153 – 16513
    Beta strandi171 – 1755
    Helixi189 – 1913
    Helixi195 – 2006
    Helixi203 – 21614
    Helixi222 – 23615
    Beta strandi239 – 2479
    Turni248 – 2503
    Beta strandi259 – 26911
    Beta strandi272 – 28110

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3MUEX-ray2.70A/B/C/D1-284[»]
    ProteinModelPortaliQ8ZRR1.
    SMRiQ8ZRR1. Positions 1-282.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8ZRR1.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pantothenate synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0414.
    HOGENOMiHOG000175517.
    KOiK01918.
    OMAiECPIVRE.
    OrthoDBiEOG6Z6FZ4.
    PhylomeDBiQ8ZRR1.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    InterProiIPR004821. Cyt_trans-like.
    IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
    PfamiPF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8ZRR1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLIIETLPLL RQHIRRLRQE GKRVALVPTM GNLHDGHMKL VDEAKARADV    50
    VIVSIFVNPM QFDRPDDLVR YPRTLQEDCE KLNKRKVDYV FAPAVEEIYP 100
    HGLEGQTYVD VPGLSTMLEG ASRPGHFRGV STIVSKLFNL IQPDIACFGE 150
    KDFQQLALIR KMVADMSYDI EIVGVPIIRA KDGLALSSRN AYLTAEQRKI 200
    APGLYNVMNS IAEKLIAGNR ELQEIIAIAE QELNEKGFRA DDIQIRDADT 250
    LLELTETSKR AVILAAAWLG QARLIDNQSV TLAQ 284
    Length:284
    Mass (Da):31,858
    Last modified:March 1, 2002 - v1
    Checksum:i219D5B538BE37E1D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL19145.1.
    RefSeqiNP_459186.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL19145; AAL19145; STM0181.
    GeneIDi1251699.
    KEGGistm:STM0181.
    PATRICi32378643. VBISalEnt20916_0191.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL19145.1 .
    RefSeqi NP_459186.1. NC_003197.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3MUE X-ray 2.70 A/B/C/D 1-284 [» ]
    ProteinModelPortali Q8ZRR1.
    SMRi Q8ZRR1. Positions 1-282.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM0181.

    Proteomic databases

    PaxDbi Q8ZRR1.
    PRIDEi Q8ZRR1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL19145 ; AAL19145 ; STM0181 .
    GeneIDi 1251699.
    KEGGi stm:STM0181.
    PATRICi 32378643. VBISalEnt20916_0191.

    Phylogenomic databases

    eggNOGi COG0414.
    HOGENOMi HOG000175517.
    KOi K01918.
    OMAi ECPIVRE.
    OrthoDBi EOG6Z6FZ4.
    PhylomeDBi Q8ZRR1.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .
    BioCyci SENT99287:GCTI-180-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q8ZRR1.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    InterProi IPR004821. Cyt_trans-like.
    IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
    Pfami PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.

    Entry informationi

    Entry nameiPANC_SALTY
    AccessioniPrimary (citable) accession number: Q8ZRR1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3