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Q8ZRQ8 (PCNB_SALTY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Poly(A) polymerase I

Short name=PAP I
EC=2.7.7.19
Gene names
Name:pcnB
Ordered Locus Names:STM0184
OrganismSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]
Taxonomic identifier99287 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length465 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control By similarity. HAMAP-Rule MF_00957

Catalytic activity

ATP + RNA(n) = diphosphate + RNA(n+1). HAMAP-Rule MF_00957

Sequence similarities

Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

Sequence caution

The sequence AAL19148.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 465465Poly(A) polymerase I HAMAP-Rule MF_00957
PRO_0000139095

Sites

Active site801 By similarity
Active site821 By similarity
Active site1621 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8ZRQ8 [UniParc].

Last modified September 19, 2006. Version 2.
Checksum: 9F6C312EDDC8C376

FASTA46553,922
        10         20         30         40         50         60 
MFTRVANFCR KVLSREESEA EQAVARPHMT IIPREQHAIS RKDISENALK VLYRLNKAGY 

        70         80         90        100        110        120 
EAYLVGGGVR DLLLGKKPKD FDVTTNATPD QVRKLFRNCR LVGRRFRLAH VMFGPEIIEV 

       130        140        150        160        170        180 
ATFRGHHEGS ESDRTTSQRG QNGMLLRDNI FGSIEEDAQR RDFTINSLYY SVADFTVRDY 

       190        200        210        220        230        240 
VGGMQDLQEG VIRLIGNPET RYREDPVRML RAVRFAAKLN MHISPETAEP IPRLATLLND 

       250        260        270        280        290        300 
IPPARLFEES LKLLQAGNGY ETYQQLREYH LFQPLFPTIT RYFTENGDSA MERIIAQVLK 

       310        320        330        340        350        360 
NTDNRIRNEM RVNPAFLFAA MFWYPLLEMA QKIAQESGLA YYDAFALAMN DVLDEACRSL 

       370        380        390        400        410        420 
AIPKRLTTLT RDIWQLQLRM SRRQGKRAWK LMEHPKFRAA FDLLELRAQV ENNTELQRLA 

       430        440        450        460 
QWWAEFQASA PPEQKGMLNE LDDDPAPRRR RSRPRKRAPR REGTV 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006468 Genomic DNA. Translation: AAL19148.1. Different initiation.
RefSeqNP_459189.1. NC_003197.1.

3D structure databases

ProteinModelPortalQ8ZRQ8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING99287.STM0184.

Proteomic databases

PaxDbQ8ZRQ8.
PRIDEQ8ZRQ8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL19148; AAL19148; STM0184.
GeneID1251702.
KEGGstm:STM0184.
PATRIC32378649. VBISalEnt20916_0194.

Phylogenomic databases

eggNOGCOG0617.
HOGENOMHOG000256527.
KOK00970.
OMARFMAKLD.
OrthoDBEOG6PZX7Q.
ProtClustDBPRK11623.

Enzyme and pathway databases

BioCycSENT99287:GCTI-183-MONOMER.

Family and domain databases

HAMAPMF_00957. PolyA_pol.
InterProIPR026007. PcnB/CCA-adding.
IPR002646. PolA_pol_head_dom.
IPR010206. PolA_pol_I.
IPR025866. PolyA_pol_arg_C_dom.
[Graphical view]
PANTHERPTHR13734:SF5. PTHR13734:SF5. 1 hit.
PfamPF01743. PolyA_pol. 1 hit.
PF12626. PolyA_pol_arg_C. 1 hit.
[Graphical view]
TIGRFAMsTIGR01942. pcnB. 1 hit.
ProtoNetSearch...

Entry information

Entry namePCNB_SALTY
AccessionPrimary (citable) accession number: Q8ZRQ8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: September 19, 2006
Last modified: February 19, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families