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Q8ZRQ8

- PCNB_SALTY

UniProt

Q8ZRQ8 - PCNB_SALTY

Protein

Poly(A) polymerase I

Gene

pcnB

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (19 Sep 2006)
      Previous versions | rss
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    Functioni

    Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control.UniRule annotation

    Catalytic activityi

    ATP + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei80 – 801UniRule annotation
    Active sitei82 – 821UniRule annotation
    Active sitei162 – 1621UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. polynucleotide adenylyltransferase activity Source: UniProtKB-HAMAP
    3. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA polyadenylation Source: InterPro
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    mRNA processing, Transcription

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-183-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Poly(A) polymerase IUniRule annotation (EC:2.7.7.19UniRule annotation)
    Short name:
    PAP IUniRule annotation
    Gene namesi
    Name:pcnBUniRule annotation
    Ordered Locus Names:STM0184
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 465465Poly(A) polymerase IPRO_0000139095Add
    BLAST

    Proteomic databases

    PaxDbiQ8ZRQ8.
    PRIDEiQ8ZRQ8.

    Interactioni

    Protein-protein interaction databases

    STRINGi99287.STM0184.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8ZRQ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0617.
    HOGENOMiHOG000256527.
    KOiK00970.
    OMAiRFMAKLD.
    OrthoDBiEOG6PZX7Q.

    Family and domain databases

    HAMAPiMF_00957. PolyA_pol.
    InterProiIPR002646. PolA_pol_head_dom.
    IPR010206. PolA_pol_I.
    IPR025866. PolyA_pol_arg_C_dom.
    [Graphical view]
    PfamiPF01743. PolyA_pol. 1 hit.
    PF12626. PolyA_pol_arg_C. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01942. pcnB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8ZRQ8-1 [UniParc]FASTAAdd to Basket

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    MFTRVANFCR KVLSREESEA EQAVARPHMT IIPREQHAIS RKDISENALK    50
    VLYRLNKAGY EAYLVGGGVR DLLLGKKPKD FDVTTNATPD QVRKLFRNCR 100
    LVGRRFRLAH VMFGPEIIEV ATFRGHHEGS ESDRTTSQRG QNGMLLRDNI 150
    FGSIEEDAQR RDFTINSLYY SVADFTVRDY VGGMQDLQEG VIRLIGNPET 200
    RYREDPVRML RAVRFAAKLN MHISPETAEP IPRLATLLND IPPARLFEES 250
    LKLLQAGNGY ETYQQLREYH LFQPLFPTIT RYFTENGDSA MERIIAQVLK 300
    NTDNRIRNEM RVNPAFLFAA MFWYPLLEMA QKIAQESGLA YYDAFALAMN 350
    DVLDEACRSL AIPKRLTTLT RDIWQLQLRM SRRQGKRAWK LMEHPKFRAA 400
    FDLLELRAQV ENNTELQRLA QWWAEFQASA PPEQKGMLNE LDDDPAPRRR 450
    RSRPRKRAPR REGTV 465
    Length:465
    Mass (Da):53,922
    Last modified:September 19, 2006 - v2
    Checksum:i9F6C312EDDC8C376
    GO

    Sequence cautioni

    The sequence AAL19148.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL19148.1. Different initiation.
    RefSeqiNP_459189.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL19148; AAL19148; STM0184.
    GeneIDi1251702.
    KEGGistm:STM0184.
    PATRICi32378649. VBISalEnt20916_0194.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL19148.1 . Different initiation.
    RefSeqi NP_459189.1. NC_003197.1.

    3D structure databases

    ProteinModelPortali Q8ZRQ8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM0184.

    Proteomic databases

    PaxDbi Q8ZRQ8.
    PRIDEi Q8ZRQ8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL19148 ; AAL19148 ; STM0184 .
    GeneIDi 1251702.
    KEGGi stm:STM0184.
    PATRICi 32378649. VBISalEnt20916_0194.

    Phylogenomic databases

    eggNOGi COG0617.
    HOGENOMi HOG000256527.
    KOi K00970.
    OMAi RFMAKLD.
    OrthoDBi EOG6PZX7Q.

    Enzyme and pathway databases

    BioCyci SENT99287:GCTI-183-MONOMER.

    Family and domain databases

    HAMAPi MF_00957. PolyA_pol.
    InterProi IPR002646. PolA_pol_head_dom.
    IPR010206. PolA_pol_I.
    IPR025866. PolyA_pol_arg_C_dom.
    [Graphical view ]
    Pfami PF01743. PolyA_pol. 1 hit.
    PF12626. PolyA_pol_arg_C. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01942. pcnB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.

    Entry informationi

    Entry nameiPCNB_SALTY
    AccessioniPrimary (citable) accession number: Q8ZRQ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: September 19, 2006
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3