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Reviewed, UniProtKB/Swiss-Prot Q8ZR95 (COPA_SALTY)

Last modified November 25, 2008. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Copper-exporting P-type ATPase A
    EC=3.6.3.n1
Gene names
Name: copA
Ordered Locus Names: STM0498
OrganismSalmonella typhimurium [Complete proteome] [HAMAP]
Taxonomic identifier602 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

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Protein attributes

Sequence length833 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Involved in copper export By similarity. Essential for copper tolerance under both aerobic and anaerobic conditions.

Catalytic activity

ATP + H(2)O + Cu(1+)(In) = ADP + phosphate + Cu(1+)(Out).

Subcellular location

Cell membrane; Multi-pass membrane proteinProbable.

Induction

Transcriptionally regulated by cueR in response to copper ions.

Sequence similarities

Belongs to the cation transport ATPase (P-type) family. Type IB subfamily.

Contains 2 HMA domains.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 833832Copper-exporting P-type ATPase A
PRO_0000046323

Regions

Transmembrane186 – 20621 Potential
Transmembrane217 – 23721 Potential
Transmembrane253 – 27321 Potential
Transmembrane283 – 30321 Potential
Transmembrane437 – 45721 Potential
Transmembrane463 – 48321 Potential
Transmembrane778 – 79821 Potential
Transmembrane800 – 82021 Potential
Domain4 – 6562HMA 1
Domain99 – 16264HMA 2

Sites

Active site52214-aspartylphosphate intermediate Probable
Metal binding141Copper Potential
Metal binding171Copper Potential
Metal binding1091Copper Potential
Metal binding1121Copper Potential
Metal binding7191Magnesium By similarity
Metal binding7231Magnesium By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q8ZR95-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 5A56C403D54BCA09

FASTA83387,910
        10         20         30         40         50         60 
MSQTIDLTLD GLSCGHCVKR VKESLEQRPD VELADVTVTE AHVTGTASAD ALIETIKQAG 

        70         80         90        100        110        120 
YGATLSHPKA KPLTESSIPS EALAAVPHEL PVATADEESQ QLLLSGMSCA SCVTRVQHAL 

       130        140        150        160        170        180 
QSVPGVTQAR VNLAERTALV MGSASAADLV QAVEKAGYGA EAIEDDIKRR ERQQETAIAT 

       190        200        210        220        230        240 
MKRFRWQAIV ALAVGIPVMV WGMIGDNMMV TDDNRSLWLA IGLITLAVMV FAGGHFYRNA 

       250        260        270        280        290        300 
WKSLLNGTAT MDTLVALGTG VAWLYSMSVN LWPQWFPMEA RHLYYEASAM IIGLINLGHM 

       310        320        330        340        350        360 
LEARARQRSS KALEKLLDLT PPTARVVTED GEKSVPLADV QPGMLLRLTT GDRVPVDGEI 

       370        380        390        400        410        420 
TQGEAWLDEA MLTGEPIPQQ KGEGDSVHAG TVVQDGSVLF RASAVGSHTT LSRIIRMVRQ 

       430        440        450        460        470        480 
AQSSKPEIGQ LADKISAVFV PVVVAIALFS AAIWYFFGPA PQIVYTLVIA TTVLIIACPC 

       490        500        510        520        530        540 
ALGLATPMSI ISGVGRAAEF GVLVRDADAL QRASTLDTLV FDKTGTLTEG KPQVVAIKTF 

       550        560        570        580        590        600 
NGVEEAQALR LAAALEQGSS HPLAHAILEK AGDDKLPQVN GFRTLRGLGV SGEAEGHQLL 

       610        620        630        640        650        660 
LGNQALLNEQ HVATDDMTAE ITAQASQGST PVLLAIDGKA AALLAVRDPL RSDSIAALER 

       670        680        690        700        710        720 
LHNAGYRLVM LTGDNPTTAN AIAKEAGIDE VIAGVLPDGK ADAIKRLQSQ GRQVAMVGDG 

       730        740        750        760        770        780 
INDAPALAQA DVGIAMGGGS DVAIETAAIT LMRHSLMGVA DALAISRATL RNMKQNLLGA 

       790        800        810        820        830 
FIYNSIGIPV AAGILWPFTG TLLNPVVAGA AMALSSITVV SNANRLLRFK PKA

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References

« Hide 'large scale' references
[1]"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2."
McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. expand/collapse author list , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K.
Nature 413:852-856(2001) [PubMed: 11677609] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LT2 / SGSC1412 / ATCC 700720.
[2]"Dissecting the Salmonella response to copper."
Espariz M., Checa S.K., Perez Audero M.E., Pontel L.B., Soncini F.C.
Microbiology 153:2989-2997(2007) [PubMed: 17768242] [Abstract]
Cited for: FUNCTION IN COPPER TOLERANCE, REGULATION BY CUER, INDUCTION BY COPPER.
Strain: ATCC 14028s / SGSG 2262.

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Cross-references

Sequence databases

AE008719 Genomic DNA. Translation: AAL19452.1.
RefSeqNP_459493.1.

3D structure databases

HSSPHSSP built from PDB template 1K0V based on UniProtKB O32221.
ModBaseSearch...

Genome annotation databases

GeneID1252018.
GenomeReviewsGene locus STM0498 in contig AE006468_GR.
KEGGstm:STM0498.
NMPDRfig|99287.1.peg.483.

Organism-specific databases

StyGenecopA. SG?????.
CMRSearch...

Phylogenomic databases

HOGENOMQ8ZR95.

Enzyme and pathway databases

BioCycSTYP99287:STM0498-MON.

Family and domain databases

InterProIPR006416. ATPase-IB_hvy.
IPR001757. ATPase_P.
IPR006403. ATPase_P_cat/Cu.
IPR005834. Dehalogen-like_hydro.
IPR008250. E1-E2_ATPase_reg.
IPR000695. H_ATPase.
IPR006121. HeavyMe_transpt.
[Graphical view]
PANTHERPTHR11939. ATPase_P. 1 hit.
PfamPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 2 hits.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
PR00120. HATPASE.
TIGRFAMsTIGR01511. ATPase-IB1_Cu. 1 hit.
TIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 2 hits.
PS50846. HMA_2. 2 hits.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameCOPA_SALTY
AccessionPrimary (citable) accession number: Q8ZR95
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: January 23, 2007
Last modified: November 25, 2008
This is version 52 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Salmonella typhimurium

Salmonella typhimurium (strain LT2): entries, gene names and cross-references to StyGene

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents