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Protein

Putative glutamate--cysteine ligase 2

Gene

ybdK

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.UniRule annotation

Catalytic activityi

ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-587-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative glutamate--cysteine ligase 2UniRule annotation (EC:6.3.2.2UniRule annotation)
Alternative name(s):
Gamma-glutamylcysteine synthetase 2UniRule annotation
Short name:
GCS 2UniRule annotation
Short name:
Gamma-GCS 2UniRule annotation
Gene namesi
Name:ybdK
Ordered Locus Names:STM0583
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002182171 – 372Putative glutamate--cysteine ligase 2Add BLAST372

Proteomic databases

PaxDbiQ8ZR41
PRIDEiQ8ZR41

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi99287.STM0583

Structurei

Secondary structure

1372
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi14 – 23Combined sources10
Turni25 – 27Combined sources3
Helixi37 – 41Combined sources5
Helixi42 – 44Combined sources3
Beta strandi47 – 52Combined sources6
Beta strandi58 – 62Combined sources5
Beta strandi66 – 68Combined sources3
Helixi69 – 89Combined sources21
Beta strandi93 – 95Combined sources3
Helixi119 – 123Combined sources5
Helixi124 – 127Combined sources4
Beta strandi134 – 140Combined sources7
Beta strandi142 – 144Combined sources3
Helixi145 – 155Combined sources11
Helixi158 – 165Combined sources8
Helixi182 – 186Combined sources5
Helixi201 – 211Combined sources11
Beta strandi214 – 216Combined sources3
Helixi220 – 222Combined sources3
Beta strandi226 – 230Combined sources5
Turni231 – 234Combined sources4
Beta strandi235 – 242Combined sources8
Helixi247 – 267Combined sources21
Helixi274 – 279Combined sources6
Helixi280 – 289Combined sources10
Beta strandi294 – 297Combined sources4
Turni299 – 301Combined sources3
Beta strandi304 – 306Combined sources3
Helixi307 – 317Combined sources11
Helixi319 – 325Combined sources7
Helixi328 – 339Combined sources12
Helixi344 – 353Combined sources10
Helixi358 – 368Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TT4X-ray2.80A/B1-372[»]
ProteinModelPortaliQ8ZR41
SMRiQ8ZR41
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8ZR41

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106KXD Bacteria
COG2170 LUCA
HOGENOMiHOG000220942
KOiK06048
OMAiLDENKWR
PhylomeDBiQ8ZR41

Family and domain databases

HAMAPiMF_01609 Glu_cys_ligase_2, 1 hit
InterProiView protein in InterPro
IPR006336 GCS2
IPR014746 Gln_synth/guanido_kin_cat_dom
IPR011793 YbdK
PfamiView protein in Pfam
PF04107 GCS2, 1 hit
SUPFAMiSSF55931 SSF55931, 1 hit
TIGRFAMsiTIGR02050 gshA_cyan_rel, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZR41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALNDFHVSE PYTLGIELEM QVINPPGYDL SQDSSTLIDA VKPQLTAGEI
60 70 80 90 100
KHDITESMLE MATGVCRDID QAAAQLSAMQ HVILQAASEH HLGICGGGTH
110 120 130 140 150
PFQKWQRQEV CDNERYQRTL ENFGYLIQQA TVFGQHVHVG CANGDDAIYL
160 170 180 190 200
LHGLSHFVPH FIALSAASPY MQGADTRFAC ARLNIFSAFP DNGPMPWVSN
210 220 230 240 250
WQEFAGLFRR LSYTTMIDSI KDLHWDIRPS PAFGTVEVRV MDTPLTLDHA
260 270 280 290 300
INMAGLIQAT AHWLLTERPF KPQEQDYLLY KFNRFQACRY GLEGVLTDAY
310 320 330 340 350
TGDRRRLADD TLRLLDNVTP SARKLGADSA IDALRLQVKK GGNEAQYMRE
360 370
FIADGGSLIG LVQKHCEIWA GQ
Length:372
Mass (Da):41,597
Last modified:March 1, 2002 - v1
Checksum:iB448A5897F5CA496
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA Translation: AAL19534.1
RefSeqiNP_459575.1, NC_003197.2
WP_001196903.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL19534; AAL19534; STM0583
GeneIDi1252103
KEGGistm:STM0583
PATRICifig|99287.12.peg.615

Similar proteinsi

Entry informationi

Entry nameiGCS2_SALTY
AccessioniPrimary (citable) accession number: Q8ZR41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health