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Q8ZQZ6

- SYL_SALTY

UniProt

Q8ZQZ6 - SYL_SALTY

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Protein
Leucine--tRNA ligase
Gene
leuS, STM0648
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei622 – 6221ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT99287:GCTI-651-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:STM0648
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 860860Leucine--tRNA ligaseUniRule annotation
PRO_0000152078Add
BLAST

Proteomic databases

PaxDbiQ8ZQZ6.
PRIDEiQ8ZQZ6.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM0648.

Structurei

3D structure databases

ProteinModelPortaliQ8ZQZ6.
SMRiQ8ZQZ6. Positions 228-413.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi619 – 6235"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.
PhylomeDBiQ8ZQZ6.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZQZ6-1 [UniParc]FASTAAdd to Basket

« Hide

MQEQYRPEEI ESKVQLHWDE KRTFEVTEDE SKEKYYCLSM LPYPSGRLHM    50
GHVRNYTIGD VVARYQRMLG KNVLQPIGWD AFGLPAEGAA VKNNTAPAPW 100
TYDNIAYMKN QLKTLGFGYD WSREIATCTP EYYRWEQKFF TELYKKGLVY 150
KKTSAVNWCP NDQTVLANEQ VIDGCCWRCD TKVERKEIPQ WFIKITAYAD 200
ELLRDLDKLD HWPDTVKTMQ RNWIGRSEGV EITFDVKGYD NTLTVYTTRP 250
DTFMGATYLA VAAGHPLAQK AAANNAELAA FIDECRNTKV AEAEMATMEK 300
KGVDTGYKAI HPLTGEEIPV WAANFVLMEY GTGAVMAVPG HDQRDYEFAS 350
KYGLTIKPVI LAADGSEPDL SEQALTEKGV LFNSGEFDGL AFEAAFNAIA 400
DKLAEKGVGE RKVNYRLRDW GVSRQRYWGA PIPMVTLEDG TVLPTPEDQL 450
PVILPEDVVM DGITSPIKAD PEWAKTTVNG MPALRETDTF DTFMESSWYY 500
ARYTCPQYQE GMLDSKAANY WLPVDIYIGG IEHAIMHLLY FRFFHKLMRD 550
AGMVTSDEPA KQLLCQGMVL ADAFYYVGEN GERNWVSPVD AIVERDEKGR 600
IVKAKDAAGH ELVYTGMSKM SKSKNNGIDP QVMVERYGAD TVRLFMMFAS 650
PADMTLEWQE SGVEGANRFI KRVWKLVYEH TAKGPVAALN VDALSEDQKA 700
LRRDVHKTIA KVTDDIGRRQ TFNTAIAAIM ELMNKLAKAP QEGEQDRALL 750
QEALQAVVRM LNPFTPHVCF TLWQELGGEG DIDNAPWPVA DEQAMVENTT 800
LVVVQVNGKV RGKITVPVDA TEEQVRERAG QEHLVAKYLD GVTVRKVIYV 850
PGKLLNLVVG 860
Length:860
Mass (Da):96,985
Last modified:March 1, 2002 - v1
Checksum:iD5003584DFBCCAB6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL19599.1.
RefSeqiNP_459640.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL19599; AAL19599; STM0648.
GeneIDi1252168.
KEGGistm:STM0648.
PATRICi32379649. VBISalEnt20916_0684.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL19599.1 .
RefSeqi NP_459640.1. NC_003197.1.

3D structure databases

ProteinModelPortali Q8ZQZ6.
SMRi Q8ZQZ6. Positions 228-413.
ModBasei Search...

Protein-protein interaction databases

STRINGi 99287.STM0648.

Proteomic databases

PaxDbi Q8ZQZ6.
PRIDEi Q8ZQZ6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL19599 ; AAL19599 ; STM0648 .
GeneIDi 1252168.
KEGGi stm:STM0648.
PATRICi 32379649. VBISalEnt20916_0684.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.
PhylomeDBi Q8ZQZ6.

Enzyme and pathway databases

BioCyci SENT99287:GCTI-651-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiSYL_SALTY
AccessioniPrimary (citable) accession number: Q8ZQZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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