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Protein

Succinate dehydrogenase flavoprotein subunit

Gene

sdhA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth.By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.By similarity

Cofactori

FADBy similarity

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (bacterial route).By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase flavoprotein subunit (sdhA), Succinate dehydrogenase iron-sulfur subunit (sdhB)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (bacterial route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei221FADBy similarity1
Binding sitei242SubstrateBy similarity1
Binding sitei254SubstrateBy similarity1
Active sitei286Proton acceptorBy similarity1
Binding sitei354SubstrateBy similarity1
Binding sitei388FADBy similarity1
Binding sitei399SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 19FADBy similarity6
Nucleotide bindingi37 – 52FADBy similarityAdd BLAST16
Nucleotide bindingi404 – 405FADBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport, Tricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-736-MONOMER
UniPathwayiUPA00223; UER01005

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase flavoprotein subunit (EC:1.3.5.1By similarity)
Gene namesi
Name:sdhA
Ordered Locus Names:STM0734
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001586581 – 588Succinate dehydrogenase flavoprotein subunitAdd BLAST588

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei45Tele-8alpha-FAD histidineBy similarity1

Proteomic databases

PaxDbiQ8ZQU3
PRIDEiQ8ZQU3

Interactioni

Subunit structurei

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.By similarity

Protein-protein interaction databases

STRINGi99287.STM0734

Structurei

3D structure databases

ProteinModelPortaliQ8ZQU3
SMRiQ8ZQU3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C00 Bacteria
COG1053 LUCA
HOGENOMiHOG000160475
KOiK00239
OMAiGDSPWEH
PhylomeDBiQ8ZQU3

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZQU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLPVREFDA VVIGAGGAGM RAALQISQSG QTCALLSKVF PTRSHTVSAQ
60 70 80 90 100
GGITVALGNT HEDNWEWHMY DTVKGSDYIG DQDAIEYMCK TGPEAILELE
110 120 130 140 150
HMGLPFSRLD DGRIYQRPFG GQSKNFGGEQ AARTAAAADR TGHALLHTLY
160 170 180 190 200
QQNLKNHTTI FSEWYALDLV KNQDGAVVGC TALCIETGEV VYFKARATVL
210 220 230 240 250
ATGGAGRIYQ STTNAHINTG DGVGMALRAG VPVQDMEMWQ FHPTGIAGAG
260 270 280 290 300
VLVTEGCRGE GGYLLNKHGE RFMERYAPNA KDLAGRDVVA RSIMIEIREG
310 320 330 340 350
RGCDGPWGPH AKLKLDHLGK EVLESRLPGI LELSRTFAHV DPVKEPIPVI
360 370 380 390 400
PTCHYMMGGI PTKVTGQALT VNEQGEDVVI PGLFAVGEIA CVSVHGANRL
410 420 430 440 450
GGNSLLDLVV FGRAAGLHLQ ESIAEQGVLR DASESDVEGS LERLNRWNNN
460 470 480 490 500
RNGEDPVAIR KALQECMQHN FSVFREGDAM AKGLEQLKVI RERLKNARLD
510 520 530 540 550
DTSSEFNTQR VECLELDNLM ETAYATAVSA NFRTESRGAH SRFDFPERDD
560 570 580
ANWLCHTLYQ PQTESMTRRS VNMEPKLRPA FPPKIRTY
Length:588
Mass (Da):64,462
Last modified:March 1, 2002 - v1
Checksum:i260774C525A0AF0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA Translation: AAL19678.1
RefSeqiNP_459719.1, NC_003197.2
WP_000775561.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL19678; AAL19678; STM0734
GeneIDi1252254
KEGGistm:STM0734
PATRICifig|99287.12.peg.766

Similar proteinsi

Entry informationi

Entry nameiSDHA_SALTY
AccessioniPrimary (citable) accession number: Q8ZQU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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