Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8ZQU2 (SDHB_SALTY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinate dehydrogenase iron-sulfur subunit

EC=1.3.5.1
Gene names
Name:sdhB
Ordered Locus Names:STM0735
OrganismSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]
Taxonomic identifier99287 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length238 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth By similarity.

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

Binds 1 2Fe-2S cluster.

Binds 1 3Fe-4S cluster.

Binds 1 4Fe-4S cluster.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (bacterial route): step 1/1.

Subunit structure

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein By similarity.

Sequence similarities

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 4Fe-4S ferredoxin-type domain.

Sequence caution

The sequence AAL19679.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 238238Succinate dehydrogenase iron-sulfur subunit
PRO_0000158692

Regions

Domain1 – 97972Fe-2S ferredoxin-type
Domain139 – 169314Fe-4S ferredoxin-type

Sites

Metal binding551Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding601Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding751Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1491Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1521Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1551Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1591Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2061Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2121Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2161Iron-sulfur 2 (4Fe-4S) By similarity
Binding site1641Ubiquinone; shared with SdhD subunit By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8ZQU2 [UniParc].

Last modified June 6, 2002. Version 2.
Checksum: 7628F9F9F95611F3

FASTA23826,733
        10         20         30         40         50         60 
MKLEFSIYRY NPDVDNAPRM QDYTLEGEEG RDMMLLDALI QLKEKDPSLS FRRSCREGVC 

        70         80         90        100        110        120 
GSDGLNMNGK NGLACITPIS ALTQPGKKIV IRPLPGLPVI RDLVVDMGQF YAQYEKIKPY 

       130        140        150        160        170        180 
LLNNGQNPPA REHLQMPEQR EKLDGLYECI LCACCSTSCP SFWWNPDKFI GPAGLLAAYR 

       190        200        210        220        230 
FLIDSRDTET DSRLEGMSDA FSVFRCHSIM NCVSVCPKGL NPTRAIGHIK SMLLQRSA 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006468 Genomic DNA. Translation: AAL19679.1. Different initiation.
RefSeqNP_459720.1. NC_003197.1.

3D structure databases

ProteinModelPortalQ8ZQU2.
SMRQ8ZQU2. Positions 1-238.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING99287.STM0735.

Proteomic databases

PaxDbQ8ZQU2.
PRIDEQ8ZQU2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL19679; AAL19679; STM0735.
GeneID1252255.
KEGGstm:STM0735.
PATRIC32379829. VBISalEnt20916_0767.

Phylogenomic databases

eggNOGCOG0479.
HOGENOMHOG000160590.
KOK00240.
OMAQYEKIRP.
OrthoDBEOG6CK7MG.

Enzyme and pathway databases

BioCycSENT99287:GCTI-739-MONOMER.
UniPathwayUPA00223; UER01005.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsTIGR00384. dhsB. 1 hit.
PROSITEPS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSDHB_SALTY
AccessionPrimary (citable) accession number: Q8ZQU2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 6, 2002
Last modified: May 14, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways