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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.UniRule annotation

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.UniRule annotation

Pathway:ipentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Enzyme and pathway databases

BioCyciSENT99287:GCTI-790-MONOMER.
UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonaseUniRule annotation (EC:3.1.1.31UniRule annotation)
Short name:
6-P-gluconolactonaseUniRule annotation
Gene namesi
Name:pglUniRule annotation
Ordered Locus Names:STM0785
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3313316-phosphogluconolactonasePRO_0000171139Add
BLAST

Proteomic databases

PaxDbiQ8ZQR4.
PRIDEiQ8ZQR4.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM0785.

Structurei

3D structure databases

ProteinModelPortaliQ8ZQR4.
SMRiQ8ZQR4. Positions 1-331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cycloisomerase 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2706.
HOGENOMiHOG000257418.
KOiK07404.
OMAiFAYCVNE.
OrthoDBiEOG615VK7.
PhylomeDBiQ8ZQR4.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_01605. 6P_gluconolactonase.
InterProiIPR022528. 6-phosphogluconolactonase_YbhE.
IPR019405. Lactonase_7-beta_prop.
IPR011045. N2O_reductase_N.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF10282. Lactonase. 1 hit.
[Graphical view]
SUPFAMiSSF50974. SSF50974. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8ZQR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQTVYTASP ESQQIHVWSL NHEGTLTLVQ VVDVPGQVQP MVVSPDKRYL
60 70 80 90 100
YVGVRPEFRV LAYRIAPDDG ALTFAAESAL PGSPTHISTD HHGRFVFVGS
110 120 130 140 150
YNAGNVSVTR LQDGLPVELV DVVEGLDGCH SANITPDNRT LWVPALKQDR
160 170 180 190 200
ICLFTLSDDG HLVAQEPAEV NTVEGAGPRH MVFHPNRQYA YCVNELNSSV
210 220 230 240 250
DVWQLKNPHG EIECVQTLDM MPADFSDTRW AADIHITPDG RHLYACDRTA
260 270 280 290 300
SLITVFSVSE DGSVLSVEGF QPTEAQPRGF NIDNSGKYLI AAGQKSHHIA
310 320 330
VYEITGTQGL LTEKGRYAVG QGPMWVVVNA Y
Length:331
Mass (Da):36,337
Last modified:March 1, 2002 - v1
Checksum:i240B46DF97002DD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL19723.1.
RefSeqiNP_459764.1. NC_003197.1.
WP_000815468.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL19723; AAL19723; STM0785.
GeneIDi1252305.
KEGGistm:STM0785.
PATRICi32379940. VBISalEnt20916_0818.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL19723.1.
RefSeqiNP_459764.1. NC_003197.1.
WP_000815468.1. NC_003197.1.

3D structure databases

ProteinModelPortaliQ8ZQR4.
SMRiQ8ZQR4. Positions 1-331.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM0785.

Proteomic databases

PaxDbiQ8ZQR4.
PRIDEiQ8ZQR4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL19723; AAL19723; STM0785.
GeneIDi1252305.
KEGGistm:STM0785.
PATRICi32379940. VBISalEnt20916_0818.

Phylogenomic databases

eggNOGiCOG2706.
HOGENOMiHOG000257418.
KOiK07404.
OMAiFAYCVNE.
OrthoDBiEOG615VK7.
PhylomeDBiQ8ZQR4.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.
BioCyciSENT99287:GCTI-790-MONOMER.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_01605. 6P_gluconolactonase.
InterProiIPR022528. 6-phosphogluconolactonase_YbhE.
IPR019405. Lactonase_7-beta_prop.
IPR011045. N2O_reductase_N.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF10282. Lactonase. 1 hit.
[Graphical view]
SUPFAMiSSF50974. SSF50974. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry namei6PGL_SALTY
AccessioniPrimary (citable) accession number: Q8ZQR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2002
Last modified: July 22, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.