ID   RLMF_SALTY              Reviewed;         308 AA.
AC   Q8ZQN4;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   16-JUN-2009, entry version 32.
DE   RecName: Full=Ribosomal RNA large subunit methyltransferase F;
DE            EC=2.1.1.48;
DE   AltName: Full=23S rRNA mA1618 methyltransferase;
DE   AltName: Full=rRNA adenine N-6-methyltransferase;
GN   Name=rlmF; OrderedLocusNames=STM0826;
OS   Salmonella typhimurium.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90371;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   MEDLINE=21534948; PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M.,
RA   Waterston R., Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium
RT   LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Specifically methylates the adenine in position 1618 of
CC       23S rRNA (By similarity).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-
CC       homocysteine + rRNA containing N(6)-methyladenine.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC       METT10D/rlmF family.
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DR   EMBL; AE008734; AAL19762.1; -; Genomic_DNA.
DR   RefSeq; NP_459803.1; -.
DR   GeneID; 1252345; -.
DR   GenomeReviews; AE006468_GR; STM0826.
DR   KEGG; stm:STM0826; -.
DR   HOGENOM; Q8ZQN4; -.
DR   OMA; Q8ZQN4; LNFGGQN.
DR   BioCyc; STYP99287:STM0826-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008988; F:rRNA (adenine-N6-)-methyltransferase activity; IEA:HAMAP.
DR   GO; GO:0000154; P:rRNA modification; IEA:InterPro.
DR   HAMAP; MF_01848; -; 1.
DR   InterPro; IPR016909; S-AdoMet-dep_MeTrfase_YbiN_prd.
DR   InterPro; IPR010286; SAM-Mtase_prd.
DR   PANTHER; PTHR13393; DUF890; 1.
DR   Pfam; PF05971; Methyltransf_10; 1.
DR   PIRSF; PIRSF029038; Mtase_YbiN_prd; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Methyltransferase; rRNA processing;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    308       Ribosomal RNA large subunit
FT                                methyltransferase F.
FT                                /FTId=PRO_0000349948.
SQ   SEQUENCE   308 AA;  34310 MW;  F854E876812802B9 CRC64;
     MSAQKPGLHP RNRHQHRYDL AALCQTTPEL TSFLIRTPAG EQSVDFANPQ AVKALNKALL
     AHFYAVTHWD IPPGFLCPPV PGRADYIHHL ADLLGETTGS IPAQATILDV GVGANCIYPL
     IGVHEYGWRF TGSEVSDAAM SSAQAIIQAN TGLSRAIRLR RQKDPAAIFT GIIHKNEFYD
     ATLCNPPFHD SAAAARAGSE RKRRNLGQNK DDALNFGGQQ QELWCEGGEV AFIKKMIAES
     QSFRRQVLWF TTLVSRGENL PPLYRALTEA GAVKVVKKEM AQGQKQSRFI AWTFMDDDQR
     RRFITRKR
//