Q8ZQN4 (RLMF_SALTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribosomal RNA large subunit methyltransferase F
EC=2.1.1.181

Alternative name(s):
23S rRNA mA1618 methyltransferase
rRNA adenine N-6-methyltransferase

Gene names

Name:	rlmF
Ordered Locus Names:	STM0826

Organism

Salmonella typhimurium

Taxonomic identifier

90371 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Specifically methylates the adenine in position 1618 of 23S rRNA By similarity. HAMAP MF_01848
Catalytic activity	S-adenosyl-L-methionine + adenine(1618) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(1618) in 23S rRNA. HAMAP MF_01848
Subcellular location	Cytoplasm Potential HAMAP MF_01848.
Sequence similarities	Belongs to the methyltransferase superfamily. METTL16/rlmF family.

Ontologies

Keywords
Biological process	rRNA processing
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	rRNA (adenine-N6-)-methyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 308	308	Ribosomal RNA large subunit methyltransferase F HAMAP MF_01848		PRO_0000349948

Sequences

	Sequence		Length	Mass (Da)
	Q8ZQN4 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: F854E876812802B9	FASTA	308	34,310
	10 20 30 40 50 60 MSAQKPGLHP RNRHQHRYDL AALCQTTPEL TSFLIRTPAG EQSVDFANPQ AVKALNKALL 70 80 90 100 110 120 AHFYAVTHWD IPPGFLCPPV PGRADYIHHL ADLLGETTGS IPAQATILDV GVGANCIYPL 130 140 150 160 170 180 IGVHEYGWRF TGSEVSDAAM SSAQAIIQAN TGLSRAIRLR RQKDPAAIFT GIIHKNEFYD 190 200 210 220 230 240 ATLCNPPFHD SAAAARAGSE RKRRNLGQNK DDALNFGGQQ QELWCEGGEV AFIKKMIAES 250 260 270 280 290 300 QSFRRQVLWF TTLVSRGENL PPLYRALTEA GAVKVVKKEM AQGQKQSRFI AWTFMDDDQR RRFITRKR

References

[1]

"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006468 Genomic DNA. Translation: AAL19762.1.
RefSeq	NP_459803.1. NC_003197.1.
3D structure databases
ProteinModelPortal	Q8ZQN4.
ModBase	Search...
Proteomic databases
PRIDE	Q8ZQN4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1252345.
GenomeReviews	Gene locus STM0826 in contig AE006468_GR.
KEGG	stm:STM0826.
PATRIC	32380025. VBISalEnt20916_0860.
Phylogenomic databases
HOGENOM	HBG747880.
OMA	DFANPEA.
ProtClustDB	PRK11727.
Enzyme and pathway databases
BioCyc	STYP99287:STM0826-MONOMER.
Family and domain databases
HAMAP	MF_01848. 23SrRNA_methyltr_F. [Tree]
InterPro	IPR016909. rRNA_lsu_methyltransferase_F. IPR010286. SAM-Mtase_prd. [Graphical view]
KO	K06970.
PANTHER	PTHR13393. DUF890. 1 hit.
Pfam	PF05971. Methyltransf_10. 1 hit. [Graphical view]
PIRSF	PIRSF029038. Mtase_YbiN_prd. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RLMF_SALTY

Accession

Primary (citable) accession number: Q8ZQN4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program