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Protein

Glyoxylate/hydroxypyruvate reductase A

Gene

ghrA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.UniRule annotation

Catalytic activityi

Glycolate + NADP+ = glyoxylate + NADPH.UniRule annotation
D-glycerate + NAD(P)+ = hydroxypyruvate + NAD(P)H.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei227 – 2271UniRule annotation
Active sitei275 – 2751Proton donorUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1144-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glyoxylate/hydroxypyruvate reductase AUniRule annotation (EC:1.1.1.79UniRule annotation, EC:1.1.1.81UniRule annotation)
Alternative name(s):
2-ketoacid reductaseUniRule annotation
Gene namesi
Name:ghrAUniRule annotation
Ordered Locus Names:STM1135
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Glyoxylate/hydroxypyruvate reductase APRO_0000348372Add
BLAST

Proteomic databases

PaxDbiQ8ZQ30.
PRIDEiQ8ZQ30.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM1135.

Structurei

Secondary structure

312
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1 – 66Combined sources
Beta strandi8 – 103Combined sources
Helixi12 – 2211Combined sources
Beta strandi26 – 305Combined sources
Beta strandi40 – 467Combined sources
Helixi49 – 524Combined sources
Beta strandi58 – 658Combined sources
Helixi68 – 769Combined sources
Helixi78 – 803Combined sources
Beta strandi87 – 893Combined sources
Helixi96 – 11116Combined sources
Helixi114 – 1229Combined sources
Helixi134 – 1363Combined sources
Beta strandi139 – 1424Combined sources
Helixi146 – 15611Combined sources
Turni157 – 1593Combined sources
Beta strandi162 – 1687Combined sources
Beta strandi176 – 1805Combined sources
Helixi181 – 1899Combined sources
Beta strandi192 – 1965Combined sources
Helixi202 – 2043Combined sources
Helixi210 – 2134Combined sources
Beta strandi220 – 2245Combined sources
Helixi228 – 2303Combined sources
Helixi233 – 2419Combined sources
Beta strandi244 – 2518Combined sources
Beta strandi254 – 2574Combined sources
Helixi263 – 2664Combined sources
Beta strandi270 – 2723Combined sources
Helixi282 – 29817Combined sources
Turni308 – 3114Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KBOX-ray2.14A/B/C/D1-312[»]
3PP8X-ray2.10A1-312[»]
ProteinModelPortaliQ8ZQ30.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8ZQ30.

Family & Domainsi

Sequence similaritiesi

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105JPG. Bacteria.
COG0111. LUCA.
HOGENOMiHOG000136694.
KOiK12972.
OMAiHKAIPQA.
PhylomeDBiQ8ZQ30.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01666. 2_Hacid_dh_C_GhrA. 1 hit.
InterProiIPR006140. D-isomer_DH_NAD-bd.
IPR023514. GhrA.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZQ30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIIFYHPTF NAAWWVNALE KALPHARVRE WKVGDNNPAD YALVWQPPVE
60 70 80 90 100
MLAGRRLKAV FVLGAGVDAI LSKLNAHPEM LDASIPLFRL EDTGMGLQMQ
110 120 130 140 150
EYAVSQVLHW FRRFDDYQAL KNQALWKPLP EYTREEFSVG IMGAGVLGAK
160 170 180 190 200
VAESLQAWGF PLRCWSRSRK SWPGVESYVG REELRAFLNQ TRVLINLLPN
210 220 230 240 250
TAQTVGIINS ELLDQLPDGA YVLNLARGVH VQEADLLAAL DSGKLKGAML
260 270 280 290 300
DVFSQEPLPQ ESPLWRHPRV AMTPHIAAVT RPAEAIDYIS RTITQLEKGE
310
PVTGQVDRAR GY
Length:312
Mass (Da):35,034
Last modified:March 1, 2002 - v1
Checksum:iA46D708D25A7AD11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL20065.1.
RefSeqiNP_460106.1. NC_003197.1.
WP_000402556.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20065; AAL20065; STM1135.
GeneIDi1252653.
KEGGistm:STM1135.
PATRICi32380715. VBISalEnt20916_1202.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL20065.1.
RefSeqiNP_460106.1. NC_003197.1.
WP_000402556.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KBOX-ray2.14A/B/C/D1-312[»]
3PP8X-ray2.10A1-312[»]
ProteinModelPortaliQ8ZQ30.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM1135.

Proteomic databases

PaxDbiQ8ZQ30.
PRIDEiQ8ZQ30.

Protocols and materials databases

DNASUi1252653.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL20065; AAL20065; STM1135.
GeneIDi1252653.
KEGGistm:STM1135.
PATRICi32380715. VBISalEnt20916_1202.

Phylogenomic databases

eggNOGiENOG4105JPG. Bacteria.
COG0111. LUCA.
HOGENOMiHOG000136694.
KOiK12972.
OMAiHKAIPQA.
PhylomeDBiQ8ZQ30.

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1144-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ8ZQ30.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01666. 2_Hacid_dh_C_GhrA. 1 hit.
InterProiIPR006140. D-isomer_DH_NAD-bd.
IPR023514. GhrA.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGHRA_SALTY
AccessioniPrimary (citable) accession number: Q8ZQ30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.