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Q8ZQ16 (RLUC_SALTY) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribosomal large subunit pseudouridine synthase C

EC=5.4.99.24
Alternative name(s):
23S rRNA pseudouridine(955/2504/2580) synthase
rRNA pseudouridylate synthase C
rRNA-uridine isomerase C
Gene names
Name:rluC
Ordered Locus Names:STM1187
OrganismSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]
Taxonomic identifier99287 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA By similarity.

Catalytic activity

23S rRNA uridine(955)/uridine(2504)/uridine(2580) = 23S rRNA pseudouridine(955)/pseudouridine(2504)/pseudouridine(2580).

Sequence similarities

Belongs to the pseudouridine synthase RluA family.

Contains 1 S4 RNA-binding domain.

Ontologies

Keywords
   Biological processrRNA processing
   LigandRNA-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpseudouridine synthesis

Inferred from electronic annotation. Source: InterPro

rRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

pseudouridine synthase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 319319Ribosomal large subunit pseudouridine synthase C
PRO_0000162677

Regions

Domain20 – 8364S4 RNA-binding

Sites

Active site1441 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8ZQ16 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 1C81A379595775D0

FASTA31935,939
        10         20         30         40         50         60 
MKTETPSVKI VAIAADEAGQ RIDNFLRTQL KGVPKSMIYR ILRKGEVRVN KKRIKPEYKL 

        70         80         90        100        110        120 
EAGDEVRIPP VRVAEREEEA VSPHLQKVAA LADVILYEDD HILVLNKPSG TAVHGGSGLS 

       130        140        150        160        170        180 
FGVIEGLRAL RPEARFLELV HRLDRDTSGV LLVAKKRSAL RSLHEQLREK GMQKDYLALV 

       190        200        210        220        230        240 
RGQWQSHVKT VQAPLLKNIL QSGERIVRVS QEGKPSETRF KVEERYAFAT LVRCSPVTGR 

       250        260        270        280        290        300 
THQIRVHTQY AGHPIAFDDR YGDREFDQQL TEAGTGLKRL FLHAAALKFT HPGTGEVMRI 

       310 
EAPMDNALKR CLQVLRNAK 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006468 Genomic DNA. Translation: AAL20116.1.
RefSeqNP_460157.1. NC_003197.1.

3D structure databases

ProteinModelPortalQ8ZQ16.
SMRQ8ZQ16. Positions 89-317.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING99287.STM1187.

Proteomic databases

PaxDbQ8ZQ16.
PRIDEQ8ZQ16.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL20116; AAL20116; STM1187.
GeneID1252705.
KEGGstm:STM1187.
PATRIC32380821. VBISalEnt20916_1255.

Phylogenomic databases

eggNOGCOG0564.
HOGENOMHOG000275914.
KOK06179.
OMAEAPMDEQ.
OrthoDBEOG6P070X.
ProtClustDBPRK11025.

Enzyme and pathway databases

BioCycSENT99287:GCTI-1196-MONOMER.

Family and domain databases

Gene3D3.10.290.10. 1 hit.
InterProIPR020103. PsdUridine_synth_cat_dom.
IPR006225. PsdUridine_synth_RluC/D.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamPF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTSM00363. S4. 1 hit.
[Graphical view]
SUPFAMSSF55120. SSF55120. 1 hit.
TIGRFAMsTIGR00005. rluA_subfam. 1 hit.
PROSITEPS01129. PSI_RLU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRLUC_SALTY
AccessionPrimary (citable) accession number: Q8ZQ16
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: March 1, 2002
Last modified: November 13, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families