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Protein

Ribosomal large subunit pseudouridine synthase C

Gene

rluC

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA.By similarity

Catalytic activityi

23S rRNA uridine(955)/uridine(2504)/uridine(2580) = 23S rRNA pseudouridine(955)/pseudouridine(2504)/pseudouridine(2580).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei144By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal large subunit pseudouridine synthase C (EC:5.4.99.24)
Alternative name(s):
23S rRNA pseudouridine(955/2504/2580) synthase
rRNA pseudouridylate synthase C
rRNA-uridine isomerase C
Gene namesi
Name:rluC
Ordered Locus Names:STM1187
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001626771 – 319Ribosomal large subunit pseudouridine synthase CAdd BLAST319

Proteomic databases

PaxDbiQ8ZQ16.
PRIDEiQ8ZQ16.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM1187.

Structurei

3D structure databases

ProteinModelPortaliQ8ZQ16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 83S4 RNA-bindingPROSITE-ProRule annotationAdd BLAST64

Sequence similaritiesi

Belongs to the pseudouridine synthase RluA family.Curated
Contains 1 S4 RNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105EI2. Bacteria.
COG0564. LUCA.
HOGENOMiHOG000275914.
KOiK06179.
OMAiEAPMDEQ.
PhylomeDBiQ8ZQ16.

Family and domain databases

Gene3Di3.10.290.10. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR006225. PsdUridine_synth_RluC/D.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00005. rluA_subfam. 1 hit.
PROSITEiPS01129. PSI_RLU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZQ16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTETPSVKI VAIAADEAGQ RIDNFLRTQL KGVPKSMIYR ILRKGEVRVN
60 70 80 90 100
KKRIKPEYKL EAGDEVRIPP VRVAEREEEA VSPHLQKVAA LADVILYEDD
110 120 130 140 150
HILVLNKPSG TAVHGGSGLS FGVIEGLRAL RPEARFLELV HRLDRDTSGV
160 170 180 190 200
LLVAKKRSAL RSLHEQLREK GMQKDYLALV RGQWQSHVKT VQAPLLKNIL
210 220 230 240 250
QSGERIVRVS QEGKPSETRF KVEERYAFAT LVRCSPVTGR THQIRVHTQY
260 270 280 290 300
AGHPIAFDDR YGDREFDQQL TEAGTGLKRL FLHAAALKFT HPGTGEVMRI
310
EAPMDNALKR CLQVLRNAK
Length:319
Mass (Da):35,939
Last modified:March 1, 2002 - v1
Checksum:i1C81A379595775D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL20116.1.
RefSeqiNP_460157.1. NC_003197.1.
WP_000846319.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20116; AAL20116; STM1187.
GeneIDi1252705.
KEGGistm:STM1187.
PATRICi32380821. VBISalEnt20916_1255.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL20116.1.
RefSeqiNP_460157.1. NC_003197.1.
WP_000846319.1. NC_003197.1.

3D structure databases

ProteinModelPortaliQ8ZQ16.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM1187.

Proteomic databases

PaxDbiQ8ZQ16.
PRIDEiQ8ZQ16.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL20116; AAL20116; STM1187.
GeneIDi1252705.
KEGGistm:STM1187.
PATRICi32380821. VBISalEnt20916_1255.

Phylogenomic databases

eggNOGiENOG4105EI2. Bacteria.
COG0564. LUCA.
HOGENOMiHOG000275914.
KOiK06179.
OMAiEAPMDEQ.
PhylomeDBiQ8ZQ16.

Family and domain databases

Gene3Di3.10.290.10. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR006225. PsdUridine_synth_RluC/D.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00005. rluA_subfam. 1 hit.
PROSITEiPS01129. PSI_RLU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRLUC_SALTY
AccessioniPrimary (citable) accession number: Q8ZQ16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.