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Q8ZQ16

- RLUC_SALTY

UniProt

Q8ZQ16 - RLUC_SALTY

Protein

Ribosomal large subunit pseudouridine synthase C

Gene

rluC

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA.By similarity

    Catalytic activityi

    23S rRNA uridine(955)/uridine(2504)/uridine(2580) = 23S rRNA pseudouridine(955)/pseudouridine(2504)/pseudouridine(2580).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei144 – 1441By similarity

    GO - Molecular functioni

    1. pseudouridine synthase activity Source: InterPro
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. pseudouridine synthesis Source: InterPro
    2. rRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    rRNA processing

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-1196-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal large subunit pseudouridine synthase C (EC:5.4.99.24)
    Alternative name(s):
    23S rRNA pseudouridine(955/2504/2580) synthase
    rRNA pseudouridylate synthase C
    rRNA-uridine isomerase C
    Gene namesi
    Name:rluC
    Ordered Locus Names:STM1187
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 319319Ribosomal large subunit pseudouridine synthase CPRO_0000162677Add
    BLAST

    Proteomic databases

    PaxDbiQ8ZQ16.
    PRIDEiQ8ZQ16.

    Interactioni

    Protein-protein interaction databases

    STRINGi99287.STM1187.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8ZQ16.
    SMRiQ8ZQ16. Positions 89-317.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 8364S4 RNA-bindingPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the pseudouridine synthase RluA family.Curated
    Contains 1 S4 RNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0564.
    HOGENOMiHOG000275914.
    KOiK06179.
    OMAiEAPMDEQ.
    OrthoDBiEOG6P070X.
    PhylomeDBiQ8ZQ16.

    Family and domain databases

    Gene3Di3.10.290.10. 1 hit.
    InterProiIPR020103. PsdUridine_synth_cat_dom.
    IPR006225. PsdUridine_synth_RluC/D.
    IPR006224. PsdUridine_synth_RluC/D_CS.
    IPR006145. PsdUridine_synth_RsuA/RluD.
    IPR002942. S4_RNA-bd.
    [Graphical view]
    PfamiPF00849. PseudoU_synth_2. 1 hit.
    PF01479. S4. 1 hit.
    [Graphical view]
    SMARTiSM00363. S4. 1 hit.
    [Graphical view]
    SUPFAMiSSF55120. SSF55120. 1 hit.
    TIGRFAMsiTIGR00005. rluA_subfam. 1 hit.
    PROSITEiPS01129. PSI_RLU. 1 hit.
    PS50889. S4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8ZQ16-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTETPSVKI VAIAADEAGQ RIDNFLRTQL KGVPKSMIYR ILRKGEVRVN    50
    KKRIKPEYKL EAGDEVRIPP VRVAEREEEA VSPHLQKVAA LADVILYEDD 100
    HILVLNKPSG TAVHGGSGLS FGVIEGLRAL RPEARFLELV HRLDRDTSGV 150
    LLVAKKRSAL RSLHEQLREK GMQKDYLALV RGQWQSHVKT VQAPLLKNIL 200
    QSGERIVRVS QEGKPSETRF KVEERYAFAT LVRCSPVTGR THQIRVHTQY 250
    AGHPIAFDDR YGDREFDQQL TEAGTGLKRL FLHAAALKFT HPGTGEVMRI 300
    EAPMDNALKR CLQVLRNAK 319
    Length:319
    Mass (Da):35,939
    Last modified:March 1, 2002 - v1
    Checksum:i1C81A379595775D0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL20116.1.
    RefSeqiNP_460157.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL20116; AAL20116; STM1187.
    GeneIDi1252705.
    KEGGistm:STM1187.
    PATRICi32380821. VBISalEnt20916_1255.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL20116.1 .
    RefSeqi NP_460157.1. NC_003197.1.

    3D structure databases

    ProteinModelPortali Q8ZQ16.
    SMRi Q8ZQ16. Positions 89-317.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM1187.

    Proteomic databases

    PaxDbi Q8ZQ16.
    PRIDEi Q8ZQ16.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL20116 ; AAL20116 ; STM1187 .
    GeneIDi 1252705.
    KEGGi stm:STM1187.
    PATRICi 32380821. VBISalEnt20916_1255.

    Phylogenomic databases

    eggNOGi COG0564.
    HOGENOMi HOG000275914.
    KOi K06179.
    OMAi EAPMDEQ.
    OrthoDBi EOG6P070X.
    PhylomeDBi Q8ZQ16.

    Enzyme and pathway databases

    BioCyci SENT99287:GCTI-1196-MONOMER.

    Family and domain databases

    Gene3Di 3.10.290.10. 1 hit.
    InterProi IPR020103. PsdUridine_synth_cat_dom.
    IPR006225. PsdUridine_synth_RluC/D.
    IPR006224. PsdUridine_synth_RluC/D_CS.
    IPR006145. PsdUridine_synth_RsuA/RluD.
    IPR002942. S4_RNA-bd.
    [Graphical view ]
    Pfami PF00849. PseudoU_synth_2. 1 hit.
    PF01479. S4. 1 hit.
    [Graphical view ]
    SMARTi SM00363. S4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55120. SSF55120. 1 hit.
    TIGRFAMsi TIGR00005. rluA_subfam. 1 hit.
    PROSITEi PS01129. PSI_RLU. 1 hit.
    PS50889. S4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.

    Entry informationi

    Entry nameiRLUC_SALTY
    AccessioniPrimary (citable) accession number: Q8ZQ16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2003
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3