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Q8ZQ16

- RLUC_SALTY

UniProt

Q8ZQ16 - RLUC_SALTY

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Protein

Ribosomal large subunit pseudouridine synthase C

Gene

rluC

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA.By similarity

Catalytic activityi

23S rRNA uridine(955)/uridine(2504)/uridine(2580) = 23S rRNA pseudouridine(955)/pseudouridine(2504)/pseudouridine(2580).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei144 – 1441By similarity

GO - Molecular functioni

  1. pseudouridine synthase activity Source: InterPro
  2. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. pseudouridine synthesis Source: InterPro
  2. rRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1196-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal large subunit pseudouridine synthase C (EC:5.4.99.24)
Alternative name(s):
23S rRNA pseudouridine(955/2504/2580) synthase
rRNA pseudouridylate synthase C
rRNA-uridine isomerase C
Gene namesi
Name:rluC
Ordered Locus Names:STM1187
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Ribosomal large subunit pseudouridine synthase CPRO_0000162677Add
BLAST

Proteomic databases

PaxDbiQ8ZQ16.
PRIDEiQ8ZQ16.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM1187.

Structurei

3D structure databases

ProteinModelPortaliQ8ZQ16.
SMRiQ8ZQ16. Positions 89-317.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 8364S4 RNA-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the pseudouridine synthase RluA family.Curated
Contains 1 S4 RNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0564.
HOGENOMiHOG000275914.
KOiK06179.
OMAiEAPMDEQ.
OrthoDBiEOG6P070X.
PhylomeDBiQ8ZQ16.

Family and domain databases

Gene3Di3.10.290.10. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR006225. PsdUridine_synth_RluC/D.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00005. rluA_subfam. 1 hit.
PROSITEiPS01129. PSI_RLU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZQ16 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTETPSVKI VAIAADEAGQ RIDNFLRTQL KGVPKSMIYR ILRKGEVRVN
60 70 80 90 100
KKRIKPEYKL EAGDEVRIPP VRVAEREEEA VSPHLQKVAA LADVILYEDD
110 120 130 140 150
HILVLNKPSG TAVHGGSGLS FGVIEGLRAL RPEARFLELV HRLDRDTSGV
160 170 180 190 200
LLVAKKRSAL RSLHEQLREK GMQKDYLALV RGQWQSHVKT VQAPLLKNIL
210 220 230 240 250
QSGERIVRVS QEGKPSETRF KVEERYAFAT LVRCSPVTGR THQIRVHTQY
260 270 280 290 300
AGHPIAFDDR YGDREFDQQL TEAGTGLKRL FLHAAALKFT HPGTGEVMRI
310
EAPMDNALKR CLQVLRNAK
Length:319
Mass (Da):35,939
Last modified:March 1, 2002 - v1
Checksum:i1C81A379595775D0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL20116.1.
RefSeqiNP_460157.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20116; AAL20116; STM1187.
GeneIDi1252705.
KEGGistm:STM1187.
PATRICi32380821. VBISalEnt20916_1255.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL20116.1 .
RefSeqi NP_460157.1. NC_003197.1.

3D structure databases

ProteinModelPortali Q8ZQ16.
SMRi Q8ZQ16. Positions 89-317.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM1187.

Proteomic databases

PaxDbi Q8ZQ16.
PRIDEi Q8ZQ16.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL20116 ; AAL20116 ; STM1187 .
GeneIDi 1252705.
KEGGi stm:STM1187.
PATRICi 32380821. VBISalEnt20916_1255.

Phylogenomic databases

eggNOGi COG0564.
HOGENOMi HOG000275914.
KOi K06179.
OMAi EAPMDEQ.
OrthoDBi EOG6P070X.
PhylomeDBi Q8ZQ16.

Enzyme and pathway databases

BioCyci SENT99287:GCTI-1196-MONOMER.

Family and domain databases

Gene3Di 3.10.290.10. 1 hit.
InterProi IPR020103. PsdUridine_synth_cat_dom.
IPR006225. PsdUridine_synth_RluC/D.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view ]
Pfami PF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view ]
SMARTi SM00363. S4. 1 hit.
[Graphical view ]
SUPFAMi SSF55120. SSF55120. 1 hit.
TIGRFAMsi TIGR00005. rluA_subfam. 1 hit.
PROSITEi PS01129. PSI_RLU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiRLUC_SALTY
AccessioniPrimary (citable) accession number: Q8ZQ16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: March 1, 2002
Last modified: October 1, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3