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Protein

N-acetyl-D-glucosamine kinase

Gene

nagK

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.By similarity

Catalytic activityi

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.

Pathwayi: peptidoglycan recycling

This protein is involved in the pathway peptidoglycan recycling, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan recycling and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi157Zinc1 Publication1
Metal bindingi177Zinc1 Publication1
Metal bindingi179Zinc1 Publication1
Metal bindingi184Zinc1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi4 – 11ATPSequence analysis8
Nucleotide bindingi133 – 140ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00544.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-D-glucosamine kinase (EC:2.7.1.59)
Alternative name(s):
GlcNAc kinase
Gene namesi
Name:nagK
Synonyms:ycfX
Ordered Locus Names:STM1220
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002701141 – 303N-acetyl-D-glucosamine kinaseAdd BLAST303

Proteomic databases

PaxDbiQ8ZPZ9.
PRIDEiQ8ZPZ9.

Expressioni

Inductioni

Expressed in mid-log phase, part of the nagK-cobB operon (PubMed:20889757).1 Publication

Interactioni

Protein-protein interaction databases

STRINGi99287.STM1220.

Structurei

Secondary structure

1303
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1 – 7Combined sources7
Beta strandi9 – 18Combined sources10
Beta strandi23 – 30Combined sources8
Helixi36 – 54Combined sources19
Beta strandi59 – 68Combined sources10
Turni81 – 85Combined sources5
Helixi88 – 96Combined sources9
Beta strandi100 – 104Combined sources5
Helixi105 – 114Combined sources10
Helixi119 – 121Combined sources3
Beta strandi123 – 140Combined sources18
Beta strandi143 – 145Combined sources3
Helixi155 – 157Combined sources3
Helixi162 – 168Combined sources7
Beta strandi182 – 184Combined sources3
Helixi186 – 189Combined sources4
Helixi191 – 202Combined sources12
Helixi208 – 216Combined sources9
Helixi220 – 244Combined sources25
Beta strandi247 – 253Combined sources7
Helixi254 – 257Combined sources4
Helixi260 – 263Combined sources4
Helixi266 – 268Combined sources3
Helixi270 – 272Combined sources3
Beta strandi281 – 284Combined sources4
Turni288 – 290Combined sources3
Helixi291 – 298Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AP1X-ray1.90A1-303[»]
ProteinModelPortaliQ8ZPZ9.
SMRiQ8ZPZ9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8ZPZ9.

Family & Domainsi

Sequence similaritiesi

Belongs to the ROK (NagC/XylR) family. NagK subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105EZX. Bacteria.
COG1940. LUCA.
HOGENOMiHOG000150087.
KOiK00884.
OMAiLSTHKVP.
PhylomeDBiQ8ZPZ9.

Family and domain databases

HAMAPiMF_01271. GlcNAc_kinase. 1 hit.
InterProiIPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view]
PfamiPF00480. ROK. 1 hit.
[Graphical view]
PROSITEiPS01125. ROK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZPZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYYGFDIGGT KIALGVFDST RRLQWEKRVP TPHTSYSAFL DAVCELVEEA
60 70 80 90 100
DQRFGVKGSV GIGIPGMPET EDGTLYAANV PAASGKPLRA DLSARLDRDV
110 120 130 140 150
RLDNDANCFA LSEAWDDEFT QYPLVMGLIL GTGVGGGLVL NGKPITGQSY
160 170 180 190 200
ITGEFGHMRL PVDALTLMGF DFPLRRCGCG QMGCIENYLS GRGFAWLYQH
210 220 230 240 250
YYDQSLQAPE IIALWEQGDE QAHAHVERYL DLLAVCLGNI LTIVDPDLLV
260 270 280 290 300
IGGGLSNFTA ITTQLAERLP RHLLPVARAP RIERARHGDA GGMRGAAFLH

LTD
Length:303
Mass (Da):33,060
Last modified:March 1, 2002 - v1
Checksum:i3BF0B7587DDAA469
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL20149.1.
RefSeqiNP_460190.1. NC_003197.1.
WP_000291338.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20149; AAL20149; STM1220.
GeneIDi1252738.
KEGGistm:STM1220.
PATRICi32380889. VBISalEnt20916_1289.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL20149.1.
RefSeqiNP_460190.1. NC_003197.1.
WP_000291338.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AP1X-ray1.90A1-303[»]
ProteinModelPortaliQ8ZPZ9.
SMRiQ8ZPZ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM1220.

Proteomic databases

PaxDbiQ8ZPZ9.
PRIDEiQ8ZPZ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL20149; AAL20149; STM1220.
GeneIDi1252738.
KEGGistm:STM1220.
PATRICi32380889. VBISalEnt20916_1289.

Phylogenomic databases

eggNOGiENOG4105EZX. Bacteria.
COG1940. LUCA.
HOGENOMiHOG000150087.
KOiK00884.
OMAiLSTHKVP.
PhylomeDBiQ8ZPZ9.

Enzyme and pathway databases

UniPathwayiUPA00544.

Miscellaneous databases

EvolutionaryTraceiQ8ZPZ9.

Family and domain databases

HAMAPiMF_01271. GlcNAc_kinase. 1 hit.
InterProiIPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view]
PfamiPF00480. ROK. 1 hit.
[Graphical view]
PROSITEiPS01125. ROK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAGK_SALTY
AccessioniPrimary (citable) accession number: Q8ZPZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.