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Q8ZPZ9

- NAGK_SALTY

UniProt

Q8ZPZ9 - NAGK_SALTY

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Protein
N-acetyl-D-glucosamine kinase
Gene
nagK, STM1220
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P By similarity.UniRule annotation

Catalytic activityi

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi157 – 1571Zinc
Metal bindingi177 – 1771Zinc
Metal bindingi179 – 1791Zinc
Metal bindingi184 – 1841Zinc

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 118ATP Reviewed prediction
Nucleotide bindingi133 – 1408ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. N-acetylglucosamine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. N-acetylglucosamine metabolic process Source: UniProtKB-HAMAP
  2. peptidoglycan turnover Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1229-MONOMER.
UniPathwayiUPA00544.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-D-glucosamine kinase (EC:2.7.1.59)
Alternative name(s):
GlcNAc kinase
Gene namesi
Name:nagK
Ordered Locus Names:STM1220
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303N-acetyl-D-glucosamine kinaseUniRule annotation
PRO_0000270114Add
BLAST

Proteomic databases

PaxDbiQ8ZPZ9.
PRIDEiQ8ZPZ9.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM1220.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1 – 77
Beta strandi9 – 1810
Beta strandi23 – 308
Helixi36 – 5419
Beta strandi59 – 6810
Turni81 – 855
Helixi88 – 969
Beta strandi100 – 1045
Helixi105 – 11410
Helixi119 – 1213
Beta strandi123 – 14018
Beta strandi143 – 1453
Helixi155 – 1573
Helixi162 – 1687
Beta strandi182 – 1843
Helixi186 – 1894
Helixi191 – 20212
Helixi208 – 2169
Helixi220 – 24425
Beta strandi247 – 2537
Helixi254 – 2574
Helixi260 – 2634
Helixi266 – 2683
Helixi270 – 2723
Beta strandi281 – 2844
Turni288 – 2903
Helixi291 – 2988

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2AP1X-ray1.90A1-303[»]
ProteinModelPortaliQ8ZPZ9.
SMRiQ8ZPZ9. Positions 1-303.

Miscellaneous databases

EvolutionaryTraceiQ8ZPZ9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1940.
HOGENOMiHOG000150087.
KOiK00884.
OMAiMESINES.
OrthoDBiEOG61P6P0.
PhylomeDBiQ8ZPZ9.

Family and domain databases

HAMAPiMF_01271. GlcNAc_kinase.
InterProiIPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view]
PfamiPF00480. ROK. 1 hit.
[Graphical view]
PROSITEiPS01125. ROK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZPZ9-1 [UniParc]FASTAAdd to Basket

« Hide

MYYGFDIGGT KIALGVFDST RRLQWEKRVP TPHTSYSAFL DAVCELVEEA    50
DQRFGVKGSV GIGIPGMPET EDGTLYAANV PAASGKPLRA DLSARLDRDV 100
RLDNDANCFA LSEAWDDEFT QYPLVMGLIL GTGVGGGLVL NGKPITGQSY 150
ITGEFGHMRL PVDALTLMGF DFPLRRCGCG QMGCIENYLS GRGFAWLYQH 200
YYDQSLQAPE IIALWEQGDE QAHAHVERYL DLLAVCLGNI LTIVDPDLLV 250
IGGGLSNFTA ITTQLAERLP RHLLPVARAP RIERARHGDA GGMRGAAFLH 300
LTD 303
Length:303
Mass (Da):33,060
Last modified:March 1, 2002 - v1
Checksum:i3BF0B7587DDAA469
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL20149.1.
RefSeqiNP_460190.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20149; AAL20149; STM1220.
GeneIDi1252738.
KEGGistm:STM1220.
PATRICi32380889. VBISalEnt20916_1289.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL20149.1 .
RefSeqi NP_460190.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2AP1 X-ray 1.90 A 1-303 [» ]
ProteinModelPortali Q8ZPZ9.
SMRi Q8ZPZ9. Positions 1-303.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM1220.

Proteomic databases

PaxDbi Q8ZPZ9.
PRIDEi Q8ZPZ9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL20149 ; AAL20149 ; STM1220 .
GeneIDi 1252738.
KEGGi stm:STM1220.
PATRICi 32380889. VBISalEnt20916_1289.

Phylogenomic databases

eggNOGi COG1940.
HOGENOMi HOG000150087.
KOi K00884.
OMAi MESINES.
OrthoDBi EOG61P6P0.
PhylomeDBi Q8ZPZ9.

Enzyme and pathway databases

UniPathwayi UPA00544 .
BioCyci SENT99287:GCTI-1229-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q8ZPZ9.

Family and domain databases

HAMAPi MF_01271. GlcNAc_kinase.
InterProi IPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view ]
Pfami PF00480. ROK. 1 hit.
[Graphical view ]
PROSITEi PS01125. ROK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.
  2. "Crystal structure of the putative regulatory protein."
    Midwest center for structural genomics (MCSG)
    Submitted (SEP-2005) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) IN COMPLEX WITH ZINC.

Entry informationi

Entry nameiNAGK_SALTY
AccessioniPrimary (citable) accession number: Q8ZPZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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