Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8ZPZ9

- NAGK_SALTY

UniProt

Q8ZPZ9 - NAGK_SALTY

Protein

N-acetyl-D-glucosamine kinase

Gene

nagK

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.By similarity

    Catalytic activityi

    ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi157 – 1571Zinc1 Publication
    Metal bindingi177 – 1771Zinc1 Publication
    Metal bindingi179 – 1791Zinc1 Publication
    Metal bindingi184 – 1841Zinc1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi4 – 118ATPSequence Analysis
    Nucleotide bindingi133 – 1408ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. N-acetylglucosamine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. N-acetylglucosamine metabolic process Source: UniProtKB-HAMAP
    2. peptidoglycan turnover Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-1229-MONOMER.
    UniPathwayiUPA00544.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acetyl-D-glucosamine kinase (EC:2.7.1.59)
    Alternative name(s):
    GlcNAc kinase
    Gene namesi
    Name:nagK
    Ordered Locus Names:STM1220
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 303303N-acetyl-D-glucosamine kinasePRO_0000270114Add
    BLAST

    Proteomic databases

    PaxDbiQ8ZPZ9.
    PRIDEiQ8ZPZ9.

    Interactioni

    Protein-protein interaction databases

    STRINGi99287.STM1220.

    Structurei

    Secondary structure

    303
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi1 – 77
    Beta strandi9 – 1810
    Beta strandi23 – 308
    Helixi36 – 5419
    Beta strandi59 – 6810
    Turni81 – 855
    Helixi88 – 969
    Beta strandi100 – 1045
    Helixi105 – 11410
    Helixi119 – 1213
    Beta strandi123 – 14018
    Beta strandi143 – 1453
    Helixi155 – 1573
    Helixi162 – 1687
    Beta strandi182 – 1843
    Helixi186 – 1894
    Helixi191 – 20212
    Helixi208 – 2169
    Helixi220 – 24425
    Beta strandi247 – 2537
    Helixi254 – 2574
    Helixi260 – 2634
    Helixi266 – 2683
    Helixi270 – 2723
    Beta strandi281 – 2844
    Turni288 – 2903
    Helixi291 – 2988

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2AP1X-ray1.90A1-303[»]
    ProteinModelPortaliQ8ZPZ9.
    SMRiQ8ZPZ9. Positions 1-303.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8ZPZ9.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ROK (NagC/XylR) family. NagK subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG1940.
    HOGENOMiHOG000150087.
    KOiK00884.
    OMAiMESINES.
    OrthoDBiEOG61P6P0.
    PhylomeDBiQ8ZPZ9.

    Family and domain databases

    HAMAPiMF_01271. GlcNAc_kinase.
    InterProiIPR023505. N-acetyl-D-glucosamine_kinase.
    IPR000600. ROK.
    [Graphical view]
    PfamiPF00480. ROK. 1 hit.
    [Graphical view]
    PROSITEiPS01125. ROK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8ZPZ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYYGFDIGGT KIALGVFDST RRLQWEKRVP TPHTSYSAFL DAVCELVEEA    50
    DQRFGVKGSV GIGIPGMPET EDGTLYAANV PAASGKPLRA DLSARLDRDV 100
    RLDNDANCFA LSEAWDDEFT QYPLVMGLIL GTGVGGGLVL NGKPITGQSY 150
    ITGEFGHMRL PVDALTLMGF DFPLRRCGCG QMGCIENYLS GRGFAWLYQH 200
    YYDQSLQAPE IIALWEQGDE QAHAHVERYL DLLAVCLGNI LTIVDPDLLV 250
    IGGGLSNFTA ITTQLAERLP RHLLPVARAP RIERARHGDA GGMRGAAFLH 300
    LTD 303
    Length:303
    Mass (Da):33,060
    Last modified:March 1, 2002 - v1
    Checksum:i3BF0B7587DDAA469
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL20149.1.
    RefSeqiNP_460190.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL20149; AAL20149; STM1220.
    GeneIDi1252738.
    KEGGistm:STM1220.
    PATRICi32380889. VBISalEnt20916_1289.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL20149.1 .
    RefSeqi NP_460190.1. NC_003197.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2AP1 X-ray 1.90 A 1-303 [» ]
    ProteinModelPortali Q8ZPZ9.
    SMRi Q8ZPZ9. Positions 1-303.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM1220.

    Proteomic databases

    PaxDbi Q8ZPZ9.
    PRIDEi Q8ZPZ9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL20149 ; AAL20149 ; STM1220 .
    GeneIDi 1252738.
    KEGGi stm:STM1220.
    PATRICi 32380889. VBISalEnt20916_1289.

    Phylogenomic databases

    eggNOGi COG1940.
    HOGENOMi HOG000150087.
    KOi K00884.
    OMAi MESINES.
    OrthoDBi EOG61P6P0.
    PhylomeDBi Q8ZPZ9.

    Enzyme and pathway databases

    UniPathwayi UPA00544 .
    BioCyci SENT99287:GCTI-1229-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q8ZPZ9.

    Family and domain databases

    HAMAPi MF_01271. GlcNAc_kinase.
    InterProi IPR023505. N-acetyl-D-glucosamine_kinase.
    IPR000600. ROK.
    [Graphical view ]
    Pfami PF00480. ROK. 1 hit.
    [Graphical view ]
    PROSITEi PS01125. ROK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.
    2. "Crystal structure of the putative regulatory protein."
      Midwest center for structural genomics (MCSG)
      Submitted (SEP-2005) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) IN COMPLEX WITH ZINC.

    Entry informationi

    Entry nameiNAGK_SALTY
    AccessioniPrimary (citable) accession number: Q8ZPZ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3