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Protein

Ribosomal large subunit pseudouridine synthase E

Gene

rluE

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Responsible for synthesis of pseudouridine from uracil-2457 in 23S ribosomal RNA.By similarity

Catalytic activityi

23S rRNA uridine(2457) = 23S rRNA pseudouridine(2457).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei79 – 791NucleophileBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

rRNA processing

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1246-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal large subunit pseudouridine synthase E (EC:5.4.99.20)
Alternative name(s):
rRNA pseudouridylate synthase E
rRNA-uridine isomerase E
Gene namesi
Name:rluE
Ordered Locus Names:STM1237
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Ribosomal large subunit pseudouridine synthase EPRO_0000100008Add
BLAST

Proteomic databases

PaxDbiQ8ZPZ1.
PRIDEiQ8ZPZ1.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM1237.

Structurei

3D structure databases

ProteinModelPortaliQ8ZPZ1.
SMRiQ8ZPZ1. Positions 36-215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pseudouridine synthase RsuA family.Curated

Phylogenomic databases

eggNOGiCOG1187.
HOGENOMiHOG000044955.
KOiK06181.
OMAiYWVQVER.
OrthoDBiEOG6130DV.
PhylomeDBiQ8ZPZ1.

Family and domain databases

InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR000748. PsdUridine_synth_RsuA/RluB/E/F.
IPR018496. PsdUridine_synth_RsuA/RluB_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00093. TIGR00093. 1 hit.
PROSITEiPS01149. PSI_RSU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZPZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQLISSENT MQKTSFRNHY VKRFSSRQAS KSRKENQPKR VVLFNKPYDV
60 70 80 90 100
LPQFTDEAGR RTLKDFIPVQ GVYAAGRLDR DSEGLLVLTN DGALQARLTQ
110 120 130 140 150
PGKRTGKIYY VQVEGIPDNA ALQALRTGVT LNDGPTLPAG IEIVAEPDWL
160 170 180 190 200
WPRTPPIRER KNIPTSWLKV TLYEGRNRQV RRMTAHVGHP TLRLIRYSMG
210 220
DYTLNGLDNG QWREIAQEKD R
Length:221
Mass (Da):25,330
Last modified:March 1, 2002 - v1
Checksum:i41C5F9A2FFFE6F56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL20166.1.
RefSeqiNP_460207.1. NC_003197.1.
WP_001249412.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20166; AAL20166; STM1237.
GeneIDi1252755.
KEGGistm:STM1237.
PATRICi32380927. VBISalEnt20916_1308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL20166.1.
RefSeqiNP_460207.1. NC_003197.1.
WP_001249412.1. NC_003197.1.

3D structure databases

ProteinModelPortaliQ8ZPZ1.
SMRiQ8ZPZ1. Positions 36-215.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM1237.

Proteomic databases

PaxDbiQ8ZPZ1.
PRIDEiQ8ZPZ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL20166; AAL20166; STM1237.
GeneIDi1252755.
KEGGistm:STM1237.
PATRICi32380927. VBISalEnt20916_1308.

Phylogenomic databases

eggNOGiCOG1187.
HOGENOMiHOG000044955.
KOiK06181.
OMAiYWVQVER.
OrthoDBiEOG6130DV.
PhylomeDBiQ8ZPZ1.

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1246-MONOMER.

Family and domain databases

InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR000748. PsdUridine_synth_RsuA/RluB/E/F.
IPR018496. PsdUridine_synth_RsuA/RluB_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00093. TIGR00093. 1 hit.
PROSITEiPS01149. PSI_RSU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiRLUE_SALTY
AccessioniPrimary (citable) accession number: Q8ZPZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: March 1, 2002
Last modified: May 27, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.