Q8ZPZ1 (RLUE_SALTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribosomal large subunit pseudouridine synthase E
EC=5.4.99.20

Alternative name(s):
rRNA pseudouridylate synthase E
rRNA-uridine isomerase E

Gene names

Name:	rluE
Ordered Locus Names:	STM1237

Organism

Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]

Taxonomic identifier

99287 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella › Salmonella choleraesuis › Salmonella enterica I › Salmonella typhimurium

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Responsible for synthesis of pseudouridine from uracil-2457 in 23S ribosomal RNA By similarity.
Catalytic activity	23S rRNA uridine(2457) = 23S rRNA pseudouridine(2457).
Sequence similarities	Belongs to the pseudouridine synthase RsuA family.

Ontologies

Keywords
Biological process	rRNA processing
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	pseudouridine synthesis Inferred from electronic annotation. Source: InterPro rRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	RNA binding Inferred from electronic annotation. Source: InterPro pseudouridine synthase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 221	221	Ribosomal large subunit pseudouridine synthase E		PRO_0000100008
Sites
	Active site	79	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8ZPZ1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 41C5F9A2FFFE6F56	FASTA	221	25,330
	10 20 30 40 50 60 MRQLISSENT MQKTSFRNHY VKRFSSRQAS KSRKENQPKR VVLFNKPYDV LPQFTDEAGR 70 80 90 100 110 120 RTLKDFIPVQ GVYAAGRLDR DSEGLLVLTN DGALQARLTQ PGKRTGKIYY VQVEGIPDNA 130 140 150 160 170 180 ALQALRTGVT LNDGPTLPAG IEIVAEPDWL WPRTPPIRER KNIPTSWLKV TLYEGRNRQV 190 200 210 220 RRMTAHVGHP TLRLIRYSMG DYTLNGLDNG QWREIAQEKD R

References

[1]

"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006468 Genomic DNA. Translation: AAL20166.1.
RefSeq	NP_460207.1. NC_003197.1.
3D structure databases
ProteinModelPortal	Q8ZPZ1.
SMR	Q8ZPZ1. Positions 36-215.
ModBase	Search...
Protein-protein interaction databases
STRING	99287.STM1237.
Proteomic databases
PaxDb	Q8ZPZ1.
PRIDE	Q8ZPZ1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL20166; AAL20166; STM1237.
GeneID	1252755.
KEGG	stm:STM1237.
PATRIC	32380927. VBISalEnt20916_1308.
Phylogenomic databases
eggNOG	COG1187.
HOGENOM	HOG000044955.
KO	K06181.
OMA	TWIELSI.
ProtClustDB	CLSK894081.
Family and domain databases
InterPro	IPR020103. PsdUridine_synth_cat_dom. IPR000748. PsdUridine_synth_RsuA/RluB/E/F. IPR018496. PsdUridine_synth_RsuA/RluB_CS. IPR006145. PsdUridine_synth_RsuA/RluD. [Graphical view]
Pfam	PF00849. PseudoU_synth_2. 1 hit. [Graphical view]
SUPFAM	SSF55120. PsdUridine_synth_cat_dom. 1 hit.
TIGRFAMs	TIGR00093. TIGR00093. 1 hit.
PROSITE	PS01149. PSI_RSU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RLUE_SALTY

Accession

Primary (citable) accession number: Q8ZPZ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 15, 2003
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program