Q8ZPV1 (ASTA_SALTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine N-succinyltransferase
Short name=AST
EC=2.3.1.109

Alternative name(s):
AOST

Gene names

Name:	astA
Ordered Locus Names:	STM1304

Organism

Salmonella typhimurium

Taxonomic identifier

90371 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine By similarity. HAMAP MF_01171
Catalytic activity	Succinyl-CoA + L-arginine = CoA + N(2)-succinyl-L-arginine. HAMAP MF_01171
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 1/5. HAMAP MF_01171
Induction	By nitrogen and carbon starvation, and arginine, via the ArgR and Crp transcriptional regulators. Ref.2
Sequence similarities	Belongs to the arginine N-succinyltransferase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	arginine N-succinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	Arginine N-succinyltransferase HAMAP MF_01171		PRO_0000262329
Sites
	Active site	229	1	Proton donor Potential
	Binding site	125	1	Succinyl-CoA; via amide nitrogen Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8ZPV1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 52B3BA6BB43B8767	FASTA	344	38,278
	10 20 30 40 50 60 MRVIRPVEHA DIAALMQLAG KTGGGLTSLP ANEATLAARI ERALKTWSGE LPKGEQGYVF 70 80 90 100 110 120 VLEDSETGEV GGICAIEVAV GLNDPWYNYR VGTLVHASKE LNVYNALPTL FLSNDHTGSS 130 140 150 160 170 180 ELCTLFLDPE WRKEGNGYLL SKSRFMFMAA FRDKFNEKVV AEMRGVIDEH GYSPFWQSLG 190 200 210 220 230 240 KRFFSMDFSR ADFLCGTGQK AFIAELMPKH PIYTHFLSEE AQAVIGEVHP QTAPARAVLE 250 260 270 280 290 300 KEGFRYRHYI DIFDGGPTLE CDIDRVRAIR KSRLVEVAEG QPAPGDYPAC LVANENYHHF 310 320 330 340 RAALVRADPQ TSRLVLTAAQ LDALKCRAGD HVRLVRLCAE EKTV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.
[2]	"Role of ArgR in activation of the ast operon, encoding enzymes of the arginine succinyltransferase pathway in Salmonella typhimurium." Lu C.-D., Abdelal A.T. J. Bacteriol. 181:1934-1938(1999) [PubMed: 10074092] [Abstract] Cited for: INDUCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006468 Genomic DNA. Translation: AAL20229.1.
RefSeq	NP_460270.1. NC_003197.1.
3D structure databases
HSSP	HSSP built from PDB template 1YLE based on UniProtKB P80357.
ProteinModelPortal	Q8ZPV1.
ModBase	Search...
Proteomic databases
PRIDE	Q8ZPV1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1252822.
GenomeReviews	Gene locus STM1304 in contig AE006468_GR.
KEGG	stm:STM1304.
PATRIC	32381087. VBISalEnt20916_1386.
Phylogenomic databases
HOGENOM	HBG377601.
OMA	AGPAIEC.
ProtClustDB	PRK10456.
Enzyme and pathway databases
BioCyc	STYP99287:STM1304-MONOMER.
Family and domain databases
HAMAP	MF_01171. AstA. [Tree]
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR007041. Arg_N-succinylTrfase_Ast/AOST. IPR017650. Arginine_N-succinylTrfase_AstA. [Graphical view]
Gene3D	G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 2 hits.
KO	K00673.
Pfam	PF04958. AstA. 1 hit. [Graphical view]
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit.
TIGRFAMs	TIGR03243. Arg_catab_AOST. 1 hit. TIGR03244. Arg_catab_AstA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ASTA_SALTY

Accession

Primary (citable) accession number: Q8ZPV1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program