Q8ZPS4 (AROH_SALTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive
EC=2.5.1.54

Alternative name(s):
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
DAHP synthase
Phospho-2-keto-3-deoxyheptonate aldolase

Gene names

Name:	aroH
Ordered Locus Names:	STM1347

Organism

Salmonella typhimurium

Taxonomic identifier

90371 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) By similarity.
Catalytic activity	Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.
Sequence similarities	Belongs to the class-I DAHP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-deoxy-7-phosphoheptulonate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive		PRO_0000140845

Sequences

	Sequence		Length	Mass (Da)
	Q8ZPS4 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 7A9830B929B4C576	FASTA	348	38,750
	10 20 30 40 50 60 MNRTDELRTA RIDSLVTPTE LAQRYPVSSS VASHVTDSRR RIEKILNGED PRLLVVIGPC 70 80 90 100 110 120 SIHDLNAAME YATQLQAQRQ KHQARLEIVM RTYFEKPRTV VGWKGLISDP DLNGSYRVNY 130 140 150 160 170 180 GLELARRLLL QVNELGVPTA TEFLDMVTGQ FIADLISWGA IGARTTESQI HREMASALSC 190 200 210 220 230 240 PVGFKNGTDG NTRIAVDAIR ASRASHMFLS PDKDGQMTIY QTSGNPYGHI IMRGGKKPNY 250 260 270 280 290 300 HAEDIAAACD TLHEFDLPEH LVVDFSHGNC QKQHRRQLEV CDDICQQIRN GSTAIAGIMA 310 320 330 340 ESFLREGTQK IISGQPLIYG QSITDPCLNW EDTEVLLEKL AAAVDSRF

References

[1]

"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006468 Genomic DNA. Translation: AAL20272.1.
RefSeq	NP_460313.1. NC_003197.1.
3D structure databases
ProteinModelPortal	Q8ZPS4.
SMR	Q8ZPS4. Positions 6-347.
ModBase	Search...
Proteomic databases
PRIDE	Q8ZPS4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1252865.
GenomeReviews	Gene locus STM1347 in contig AE006468_GR.
KEGG	stm:STM1347.
PATRIC	32381175. VBISalEnt20916_1430.
Phylogenomic databases
HOGENOM	HBG670536.
OMA	ELFIVMR.
ProtClustDB	PRK12756.
Enzyme and pathway databases
BioCyc	STYP99287:STM1347-MONOMER.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006219. DHAP_synth_1. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01626.
PANTHER	PTHR21225. AroFGH. 1 hit.
Pfam	PF00793. DAHP_synth_1. 1 hit. [Graphical view]
PIRSF	PIRSF001361. DAHP_synthase. 1 hit.
TIGRFAMs	TIGR00034. AroFGH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROH_SALTY

Accession

Primary (citable) accession number: Q8ZPS4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2003
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program