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Q8ZPR4

- YDIB_SALTY

UniProt

Q8ZPR4 - YDIB_SALTY

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Protein
Quinate/shikimate dehydrogenase
Gene
ydiB, STM1359
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-quinate + NAD(P)+ = 3-dehydroquinate + NAD(P)H.UniRule annotation
Shikimate + NAD(P)+ = 3-dehydroshikimate + NAD(P)H.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei71 – 711Proton acceptor Reviewed prediction
Binding sitei107 – 1071Substrate By similarity
Binding sitei205 – 2051NAD; via amide nitrogen By similarity
Binding sitei235 – 2351NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi131 – 1355NAD By similarity
Nucleotide bindingi155 – 1584NAD By similarity
Nucleotide bindingi255 – 2595NAD By similarity

GO - Molecular functioni

  1. quinate 3-dehydrogenase (NAD+) activity Source: UniProtKB-HAMAP
  2. quinate 3-dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. shikimate 3-dehydrogenase (NAD+) activity Source: UniProtKB-EC
  4. shikimate 3-dehydrogenase (NADP+) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1369-MONOMER.
UniPathwayiUPA00053; UER00087.

Names & Taxonomyi

Protein namesi
Recommended name:
Quinate/shikimate dehydrogenase (EC:1.1.1.282)
Alternative name(s):
NAD-dependent shikimate 5-dehydrogenase 2
Gene namesi
Name:ydiB
Ordered Locus Names:STM1359
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Quinate/shikimate dehydrogenaseUniRule annotation
PRO_0000136072Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi99287.STM1359.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi8 – 158
Helixi22 – 3312
Beta strandi36 – 438
Turni46 – 483
Helixi49 – 5810
Beta strandi63 – 664
Helixi71 – 744
Helixi75 – 773
Beta strandi79 – 813
Helixi83 – 886
Beta strandi92 – 976
Beta strandi100 – 1045
Helixi106 – 11712
Beta strandi126 – 1305
Helixi134 – 14512
Beta strandi149 – 1557
Helixi160 – 17415
Beta strandi178 – 1836
Helixi187 – 19610
Beta strandi198 – 2025
Helixi220 – 2223
Beta strandi228 – 2314
Beta strandi235 – 2384
Helixi240 – 2478
Beta strandi251 – 2533
Helixi255 – 27117
Helixi277 – 2837

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3T4EX-ray1.95A/B1-288[»]
ProteinModelPortaliQ8ZPR4.
SMRiQ8ZPR4. Positions 1-288.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0169.
HOGENOMiHOG000237875.
KOiK05887.
OMAiGNVTLPH.
OrthoDBiEOG64R67G.
PhylomeDBiQ8ZPR4.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00222. Shikimate_DH_AroE.
MF_01578. Shikimate_DH_YdiB.
InterProiIPR016040. NAD(P)-bd_dom.
IPR022872. Quinate/Shikimate_DH.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_quinate_DH.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view]
PfamiPF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZPR4-1 [UniParc]FASTAAdd to Basket

« Hide

MDVTAKYELI GLMAYPIRHS LSPEMQNKAL EKAGLPYTYM AFEVDNTTFA    50
SAIEGLKALK MRGTGVSMPN KQLACEYVDE LTPAAKLVGA INTIVNDDGY 100
LRGYNTDGTG HIRAIKESGF DMRGKTMVLL GAGGAATAIG AQAAIEGIKE 150
IKLFNRKDDF FEKAVAFAKR VNENTDCVVT VTDLADQHAF TEALASADIL 200
TNGTKVGMKP LENESLIGDV SLLRPELLVT ECVYNPHMTK LLQQAQQAGC 250
KTIDGYGMLL WQGAEQFELW TGKAFPLDYV KQVMGFTA 288
Length:288
Mass (Da):31,337
Last modified:March 1, 2002 - v1
Checksum:i42984154DE6BB962
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL20284.1.
RefSeqiNP_460325.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20284; AAL20284; STM1359.
GeneIDi1252877.
KEGGistm:STM1359.
PATRICi32381201. VBISalEnt20916_1443.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL20284.1 .
RefSeqi NP_460325.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3T4E X-ray 1.95 A/B 1-288 [» ]
ProteinModelPortali Q8ZPR4.
SMRi Q8ZPR4. Positions 1-288.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM1359.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL20284 ; AAL20284 ; STM1359 .
GeneIDi 1252877.
KEGGi stm:STM1359.
PATRICi 32381201. VBISalEnt20916_1443.

Phylogenomic databases

eggNOGi COG0169.
HOGENOMi HOG000237875.
KOi K05887.
OMAi GNVTLPH.
OrthoDBi EOG64R67G.
PhylomeDBi Q8ZPR4.

Enzyme and pathway databases

UniPathwayi UPA00053 ; UER00087 .
BioCyci SENT99287:GCTI-1369-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00222. Shikimate_DH_AroE.
MF_01578. Shikimate_DH_YdiB.
InterProi IPR016040. NAD(P)-bd_dom.
IPR022872. Quinate/Shikimate_DH.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_quinate_DH.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view ]
Pfami PF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiYDIB_SALTY
AccessioniPrimary (citable) accession number: Q8ZPR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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