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Protein

Malto-oligosyltrehalose trehalohydrolase

Gene

STM1560

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of (1->4)-alpha-D-glucosidic linkage in 4-alpha-D-((1->4)-alpha-D-glucanosyl)(n) trehalose to yield trehalose and (1->4)-alpha-D-glucan.UniRule annotation

Pathwayi: trehalose biosynthesis

This protein is involved in the pathway trehalose biosynthesis, which is part of Glycan biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway trehalose biosynthesis and in Glycan biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei261NucleophileUniRule annotation1
Active sitei296Proton donorUniRule annotation1
Metal bindingi297Magnesium; via carbonyl oxygenCombined sources1
Metal bindingi319MagnesiumCombined sources1
Metal bindingi320Magnesium; via carbonyl oxygenCombined sources1
Sitei393Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidaseUniRule annotation, Hydrolase
LigandMagnesiumCombined sources, Metal-bindingCombined sources

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-1577-MONOMER.
UniPathwayiUPA00299.

Protein family/group databases

CAZyiCBM48. Carbohydrate-Binding Module Family 48.
GH13. Glycoside Hydrolase Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
Malto-oligosyltrehalose trehalohydrolaseUniRule annotation (EC:3.2.1.141UniRule annotation)
Short name:
MTHaseUniRule annotation
Alternative name(s):
4-alpha-D-((1->4)-alpha-D-glucano)trehalose trehalohydrolaseUniRule annotation
Maltooligosyl trehalose trehalohydrolaseUniRule annotation
Gene namesi
Ordered Locus Names:STM1560Imported
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)Imported
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

PTM / Processingi

Proteomic databases

PaxDbiQ8ZPF0.
PRIDEiQ8ZPF0.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM1560.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3M07X-ray1.40A1-594[»]
ProteinModelPortaliQ8ZPF0.
SMRiQ8ZPF0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8ZPF0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 453AamyInterPro annotationAdd BLAST342

Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105C9C. Bacteria.
COG0296. LUCA.
HOGENOMiHOG000155668.
KOiK01236.
OMAiFTPMLFM.
PhylomeDBiQ8ZPF0.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.1180. 1 hit.
InterProiView protein in InterPro
IPR022567. DUF3459.
IPR006047. Glyco_hydro_13_cat_dom.
IPR013780. Glyco_hydro_b.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR012768. Trehalose_TreZ.
PfamiView protein in Pfam
PF00128. Alpha-amylase. 1 hit.
PF11941. DUF3459. 1 hit.
PIRSFiPIRSF006337. Trehalose_TreZ. 1 hit.
SMARTiView protein in SMART
SM00642. Aamy. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF81296. SSF81296. 1 hit.
TIGRFAMsiTIGR02402. trehalose_TreZ. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZPF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKIFCKSW GAEYIAADVV RFRLWATGQQ KVMLRLAGKD QEMQANGDGW
60 70 80 90 100
FTLDVAGVTP GTEYNFVLSD GMVVPDPASR AQKTDVNGPS YVVDPGSYTW
110 120 130 140 150
RNTGWKGSRW EQAVVYEMHT GTFTPEGTFR AAIAKLPYLA ELGVTVIEVM
160 170 180 190 200
PVAQFGGERG WGYDGVLLYA PHSAYGTPDD FKAFIDAAHG YGLSVVLDIV
210 220 230 240 250
LNHFGPEGNY LPLLAPAFFH KERMTPWGNG IAYDVDAVRR YIIEAPLYWL
260 270 280 290 300
TEYHLDGLRF DAIDQIEDSS ARHVLVEIAQ RIREDITDRP IHLTTEDSRN
310 320 330 340 350
IISLHPRDQD GNAPLFTAEW NDDFHNAVHV FATGETQAYY NDFADAPEKH
360 370 380 390 400
LARALAEGFA YQGEISPQTG EPRGVKSTGQ PPVAFVDFIQ NHDQVGNRAQ
410 420 430 440 450
GDRLITLAGA ERTKVLLATL LLSPHIPLLF MGEEYGESRP FLFFTDFHGD
460 470 480 490 500
LARAVREGRA KEFADHAGEN VPDPNAPETF QRSKLNWKQQ HSEEGKAWLA
510 520 530 540 550
FTRELLLLRQ KHIVPLLSAA RESSGTVLQT APGFIAVSWR FPGGTLSLAL
560 570 580 590
NISATTVLLP DLPGKTLFAW PNESTGSLSQ HSLIVRLAQG ESAS
Length:594
Mass (Da):65,774
Last modified:March 1, 2002 - v1
Checksum:iB4C685D611C7E38B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL20478.1.
RefSeqiNP_460519.1. NC_003197.2.
WP_000095534.1. NC_003197.2.

Genome annotation databases

EnsemblBacteriaiAAL20478; AAL20478; STM1560.
GeneIDi1253078.
KEGGistm:STM1560.
PATRICifig|99287.12.peg.1651.

Similar proteinsi

Entry informationi

Entry nameiQ8ZPF0_SALTY
AccessioniPrimary (citable) accession number: Q8ZPF0
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: February 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported