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Reviewed, UniProtKB/Swiss-Prot Q8ZPE8 (MAO1_SALTY)

Last modified June 16, 2009. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    NAD-dependent malic enzyme
      Short name=NAD-ME
    EC=1.1.1.38
Gene names
Name: sfcA
Ordered Locus Names: STM1566
OrganismSalmonella typhimurium [Complete proteome] [HAMAP]
Taxonomic identifier90371 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length565 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

(S)-malate + NAD+ = pyruvate + CO2 + NADH. HAMAP MF_01619

Cofactor

Divalent metal cations. Prefers magnesium or manganese By similarity.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the malic enzymes family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 565565NAD-dependent malic enzyme HAMAP MF_01619
PRO_0000160231

Sites

Active site1041Proton donor By similarity
Active site1751Proton acceptor By similarity
Metal binding2461Divalent metal cation By similarity
Metal binding2471Divalent metal cation By similarity
Metal binding2701Divalent metal cation By similarity
Binding site1571NAD By similarity
Binding site2701NAD By similarity
Binding site4181NAD By similarity
Site2701Important for activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8ZPE8-1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 0A98386BCEC7FBCE

FASTA56562,896
        10         20         30         40         50         60 
METTTKKARS LYIPYAGPVL LEFPLLNKGS AFSVEERRNF NLSGLLPEVV ESIEEQAERA 

        70         80         90        100        110        120 
WLQYQGFKTE IDKHIYLRNI QDTNETLFYR LVQNHLEEMM PVIYTPTVGA ACERFSEIYR 

       130        140        150        160        170        180 
RARGVFISYP NRHNMDDILQ NVPNHNIKVI VVTDGERILG LGDQGIGGMG IPIGKLSLYT 

       190        200        210        220        230        240 
ACGGISPAYT LPVVLDVGTN NQQLLNDPLY MGWRHPRITD DEYYAFVDEF IQAVKQRWPD 

       250        260        270        280        290        300 
ILLQFEDFAQ KNAMPLLTRY RDEICSFNDD IQGTAAVTVG TLIAASRAAG SQLSEQKIVF 

       310        320        330        340        350        360 
LGAGSAGCGI AEQIIAQTQR EGLSEDAARQ NVFMVDRFGL LTDRMPNLLP FQAKLVQKCD 

       370        380        390        400        410        420 
NLQHWDTEND VLSLLDVVRN VKPDILIGVS GQTGLFTEEI IREMHKHCPR PIVMPLSNPT 

       430        440        450        460        470        480 
SRVEATPQDI IAWTEGNALV ATGSPFSPVI WKDKVYPIAQ CNNAYIFPGI GLGVIASGAS 

       490        500        510        520        530        540 
RITDEMLMSA SETLAKHSPL VNNGEGLVLP ALKDIQVVSR AIAFAVGKMA QQQGVAVKTS 

       550        560 
AEALQQAIDD NFWKPEYRDY RRTSI 

« Hide

Cross-references

Sequence databases

AE008768 Genomic DNA. Translation: AAL20484.1.
RefSeqNP_460525.1.

3D structure databases

HSSPHSSP built from PDB template 1O0S based on UniProtKB P27443.
ModBaseSearch...

Genome annotation databases

GeneID1253084.
GenomeReviewsGene locus STM1566 in contig AE006468_GR.
KEGGstm:STM1566.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ8ZPE8.
OMAQ8ZPE8. IQDNNET.

Enzyme and pathway databases

BioCycSTYP99287:STM1566-MON.
BRENDA1.1.1.38. 2.

Family and domain databases

HAMAPMF_01619.
[Tree]
InterProIPR015884. Malic_enzyme_CS.
IPR012301. Malic_N.
IPR012302. Malic_NAD_bd.
IPR001891. Malic_OxRdtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PfamPF00390. malic. 1 hit.
PF03949. Malic_M. 1 hit.
[Graphical view]
PRINTSPR00072. MALOXRDTASE.
PROSITEPS00331. MALIC_ENZYMES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMAO1_SALTY
AccessionPrimary (citable) accession number: Q8ZPE8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2002
Last modified: June 16, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents