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Protein

Serine/threonine-protein phosphatase 1

Gene

pphA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Can hydrolyze phosphorylated Ser-, Thr- or Tyr-substrates in vitro. The natural substrate is unknown.

Miscellaneous

Neither magnesium nor calcium stimulates activity.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Enzyme regulationi

Inhibited by cadmium, copper, zinc when added cobalt when added concomitantly with manganese.

pH dependencei

Optimum pH is 6-7.

Temperature dependencei

Optimum temperature is 45-55 degrees Celsius. Thermostable.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi24Manganese 1By similarity1
Metal bindingi26Manganese 1By similarity1
Metal bindingi53Manganese 1By similarity1
Metal bindingi53Manganese 2By similarity1
Metal bindingi79Manganese 2By similarity1
Active sitei80Proton donorBy similarity1
Metal bindingi185Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-1869-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 1 (EC:3.1.3.16)
Gene namesi
Name:pphA
Synonyms:prpA
Ordered Locus Names:STM1853
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000589091 – 216Serine/threonine-protein phosphatase 1Add BLAST216

Proteomic databases

PaxDbiQ8ZNY9

Interactioni

Protein-protein interaction databases

STRINGi99287.STM1853

Structurei

3D structure databases

ProteinModelPortaliQ8ZNY9
SMRiQ8ZNY9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

eggNOGiENOG4108R1E Bacteria
COG0639 LUCA
HOGENOMiHOG000251869
KOiK07313
OMAiMNGGDWY
PhylomeDBiQ8ZNY9

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZNY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMRPEEIYQR IEAKNWRHVW VVGDIHGCFS MLMKRLRECR FDPQQDLLVS
60 70 80 90 100
VGDLIDRGPD SLGCLALLRE SWMTAVRGNH EQMALDARAS SQSTLWLMNG
110 120 130 140 150
GDWFTRLTAE HAAQAEALFI LCQRLPWILE VRCRHSTHVI AHADYPASTY
160 170 180 190 200
QWQKKVDLHQ VLWSRERLIN KRGGISGADH FWFGHTPLRR RMDFANVHYI
210
DTGAVFGGQL TLARIQ
Length:216
Mass (Da):25,037
Last modified:March 1, 2002 - v1
Checksum:iC2A62B823F4AAAD5
GO

Sequence cautioni

The sequence AAL09831 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049950 Genomic DNA Translation: AAL09831.1 Different initiation.
AE006468 Genomic DNA Translation: AAL20768.1
RefSeqiNP_460809.1, NC_003197.2
WP_000986176.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL20768; AAL20768; STM1853
GeneIDi1253372
KEGGistm:STM1853
PATRICifig|99287.12.peg.1956

Similar proteinsi

Entry informationi

Entry nameiPRP1_SALTY
AccessioniPrimary (citable) accession number: Q8ZNY9
Secondary accession number(s): Q8VPE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health