SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8ZNY9

- PRP1_SALTY

UniProt

Q8ZNY9 - PRP1_SALTY

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Serine/threonine-protein phosphatase 1
Gene
pphA, prpA, STM1853
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Can hydrolyze phosphorylated Ser-, Thr- or Tyr-substrates in vitro. The natural substrate is unknown.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Manganese.

Enzyme regulationi

Inhibited by cadmium, copper, zinc when added cobalt when added concomitantly with manganese.

pH dependencei

Optimum pH is 6-7.

Temperature dependencei

Optimum temperature is 45-55 degrees Celsius. Thermostable.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi24 – 241Manganese 1 By similarity
Metal bindingi26 – 261Manganese 1 By similarity
Metal bindingi53 – 531Manganese 1 By similarity
Metal bindingi53 – 531Manganese 2 By similarity
Metal bindingi79 – 791Manganese 2 By similarity
Active sitei80 – 801Proton donor By similarity
Metal bindingi185 – 1851Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1861-MONOMER.

Protein family/group databases

PptaseDBiP3D0411148.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 1 (EC:3.1.3.16)
Gene namesi
Name:pphA
Synonyms:prpA
Ordered Locus Names:STM1853
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216Serine/threonine-protein phosphatase 1
PRO_0000058909Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi99287.STM1853.

Structurei

3D structure databases

ProteinModelPortaliQ8ZNY9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000251869.
KOiK07313.
OMAiHDEFVIN.
OrthoDBiEOG6KDKSC.
PhylomeDBiQ8ZNY9.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZNY9-1 [UniParc]FASTAAdd to Basket

« Hide

MMRPEEIYQR IEAKNWRHVW VVGDIHGCFS MLMKRLRECR FDPQQDLLVS    50
VGDLIDRGPD SLGCLALLRE SWMTAVRGNH EQMALDARAS SQSTLWLMNG 100
GDWFTRLTAE HAAQAEALFI LCQRLPWILE VRCRHSTHVI AHADYPASTY 150
QWQKKVDLHQ VLWSRERLIN KRGGISGADH FWFGHTPLRR RMDFANVHYI 200
DTGAVFGGQL TLARIQ 216
Length:216
Mass (Da):25,037
Last modified:March 1, 2002 - v1
Checksum:iC2A62B823F4AAAD5
GO

Sequence cautioni

The sequence AAL09831.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY049950 Genomic DNA. Translation: AAL09831.1. Different initiation.
AE006468 Genomic DNA. Translation: AAL20768.1.
RefSeqiNP_460809.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20768; AAL20768; STM1853.
GeneIDi1253372.
KEGGistm:STM1853.
PATRICi32382235. VBISalEnt20916_1956.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY049950 Genomic DNA. Translation: AAL09831.1 . Different initiation.
AE006468 Genomic DNA. Translation: AAL20768.1 .
RefSeqi NP_460809.1. NC_003197.1.

3D structure databases

ProteinModelPortali Q8ZNY9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM1853.

Protein family/group databases

PptaseDBi P3D0411148.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL20768 ; AAL20768 ; STM1853 .
GeneIDi 1253372.
KEGGi stm:STM1853.
PATRICi 32382235. VBISalEnt20916_1956.

Phylogenomic databases

eggNOGi COG0639.
HOGENOMi HOG000251869.
KOi K07313.
OMAi HDEFVIN.
OrthoDBi EOG6KDKSC.
PhylomeDBi Q8ZNY9.

Enzyme and pathway databases

BioCyci SENT99287:GCTI-1861-MONOMER.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The PPP-family protein phosphatases PrpA and PrpB of Salmonella enterica serovar Typhimurium possess distinct biochemical properties."
    Shi L., Kehres D.G., Maguire M.E.
    J. Bacteriol. 183:7053-7057(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiPRP1_SALTY
AccessioniPrimary (citable) accession number: Q8ZNY9
Secondary accession number(s): Q8VPE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Neither magnesium nor calcium stimulates activity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi