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Q8ZNW0

- KPYK2_SALTY

UniProt

Q8ZNW0 - KPYK2_SALTY

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Protein
Pyruvate kinase II
Gene
pykA, STM1888
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Magnesium By similarity.
Potassium By similarity.

Enzyme regulationi

Allosterically activated by AMP and by several sugar phosphates. Belongs to type II PK By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361Substrate By similarity
Metal bindingi38 – 381Potassium By similarity
Metal bindingi40 – 401Potassium By similarity
Metal bindingi70 – 701Potassium By similarity
Sitei223 – 2231Transition state stabilizer By similarity
Metal bindingi225 – 2251Magnesium By similarity
Binding sitei251 – 2511Substrate; via amide nitrogen By similarity
Metal bindingi252 – 2521Magnesium By similarity
Binding sitei252 – 2521Substrate; via amide nitrogen By similarity
Binding sitei284 – 2841Substrate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. potassium ion binding Source: InterPro
  4. pyruvate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Pyruvate

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1900-MONOMER.
UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase II (EC:2.7.1.40)
Alternative name(s):
PK-2
Gene namesi
Name:pykA
Ordered Locus Names:STM1888
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 480479Pyruvate kinase II
PRO_0000112074Add
BLAST

Proteomic databases

PaxDbiQ8ZNW0.
PRIDEiQ8ZNW0.

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi99287.STM1888.

Structurei

3D structure databases

ProteinModelPortaliQ8ZNW0.

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.

Phylogenomic databases

eggNOGiCOG0469.
HOGENOMiHOG000021558.
KOiK00873.
OMAiTPVYFDS.
OrthoDBiEOG6GBMB0.
PhylomeDBiQ8ZNW0.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8ZNW0-1 [UniParc]FASTAAdd to Basket

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MSRRLRRTKI VTTLGPATDR DNNLEKVIAA GANVVRMNFS HGSPEDHKMR    50
ADKVREIAAK LGRHVAILGD LQGPKIRVST FKEGKVFLNI GDKFLLDANL 100
GKGEGDKEKV GIDYKGLPAD VVPGDILLLD DGRVQLKVLE VQGMKVFTEV 150
TVGGPLSNNK GINKLGGGLS AEALTEKDKA DIQTAALIGV DYLAVSFPRC 200
GEDLNYARRL ARDAGCDAKI VAKVERAEAV CDQNAMDDII LASDVVMVAR 250
GDLGVEIGDP ELVGIQKALI RRARQLNRAV ITATQMMESM ITNPMPTRAE 300
VMDVANAVLD GTDAVMLSAE TAAGQYPSET VAAMARVCLG AEKIPSINVS 350
KHRLDVQFDN VEEAIAMSAM YAANHLKGVT AIITMTESGR TALMTSRISS 400
GLPIFAMSRH ERTLNLTALY RGVTPVHFDS AADGVVAAHE AVNLLRDKGY 450
LVSGDLVIVT QGDVMSTVGS TNTTRILTVE 480
Length:480
Mass (Da):51,387
Last modified:January 23, 2007 - v3
Checksum:i8BF3948FE958EFAC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL20804.1.
RefSeqiNP_460845.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20804; AAL20804; STM1888.
GeneIDi1253409.
KEGGistm:STM1888.
PATRICi32382327. VBISalEnt20916_2002.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL20804.1 .
RefSeqi NP_460845.1. NC_003197.1.

3D structure databases

ProteinModelPortali Q8ZNW0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM1888.

Proteomic databases

PaxDbi Q8ZNW0.
PRIDEi Q8ZNW0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL20804 ; AAL20804 ; STM1888 .
GeneIDi 1253409.
KEGGi stm:STM1888.
PATRICi 32382327. VBISalEnt20916_2002.

Phylogenomic databases

eggNOGi COG0469.
HOGENOMi HOG000021558.
KOi K00873.
OMAi TPVYFDS.
OrthoDBi EOG6GBMB0.
PhylomeDBi Q8ZNW0.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .
BioCyci SENT99287:GCTI-1900-MONOMER.

Family and domain databases

Gene3Di 2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProi IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiKPYK2_SALTY
AccessioniPrimary (citable) accession number: Q8ZNW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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