Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q8ZNW0 (KPYK2_SALTY) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyruvate kinase II
EC=2.7.1.40
Alternative name(s):
PK-2
Gene names
Name:pykA
Ordered Locus Names:STM1888
OrganismSalmonella typhimurium
Taxonomic identifier90371 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length480 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactor

Magnesium By similarity.

Potassium By similarity.

Enzyme regulation

Allosterically activated by AMP and by several sugar phosphates. Belongs to type II PK By similarity.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the pyruvate kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 480479Pyruvate kinase II
PRO_0000112074

Sites

Metal binding381Potassium By similarity
Metal binding401Potassium By similarity
Metal binding701Potassium By similarity
Metal binding2251Magnesium By similarity
Metal binding2521Magnesium By similarity
Binding site361Substrate By similarity
Binding site2511Substrate; via amide nitrogen By similarity
Binding site2521Substrate; via amide nitrogen By similarity
Binding site2841Substrate By similarity
Site2231Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8ZNW0 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 8BF3948FE958EFAC

FASTA48051,387
        10         20         30         40         50         60 
MSRRLRRTKI VTTLGPATDR DNNLEKVIAA GANVVRMNFS HGSPEDHKMR ADKVREIAAK 

        70         80         90        100        110        120 
LGRHVAILGD LQGPKIRVST FKEGKVFLNI GDKFLLDANL GKGEGDKEKV GIDYKGLPAD 

       130        140        150        160        170        180 
VVPGDILLLD DGRVQLKVLE VQGMKVFTEV TVGGPLSNNK GINKLGGGLS AEALTEKDKA 

       190        200        210        220        230        240 
DIQTAALIGV DYLAVSFPRC GEDLNYARRL ARDAGCDAKI VAKVERAEAV CDQNAMDDII 

       250        260        270        280        290        300 
LASDVVMVAR GDLGVEIGDP ELVGIQKALI RRARQLNRAV ITATQMMESM ITNPMPTRAE 

       310        320        330        340        350        360 
VMDVANAVLD GTDAVMLSAE TAAGQYPSET VAAMARVCLG AEKIPSINVS KHRLDVQFDN 

       370        380        390        400        410        420 
VEEAIAMSAM YAANHLKGVT AIITMTESGR TALMTSRISS GLPIFAMSRH ERTLNLTALY 

       430        440        450        460        470        480 
RGVTPVHFDS AADGVVAAHE AVNLLRDKGY LVSGDLVIVT QGDVMSTVGS TNTTRILTVE

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE006468 Genomic DNA. Translation: AAL20804.1.
RefSeqNP_460845.1. NC_003197.1.

3D structure databases

ProteinModelPortalQ8ZNW0.
ModBaseSearch...

Proteomic databases

PRIDEQ8ZNW0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1253409.
GenomeReviewsGene locus STM1888 in contig AE006468_GR.
KEGGstm:STM1888.
PATRIC32382327. VBISalEnt20916_2002.

Phylogenomic databases

HOGENOMHBG734376.
OMASRSRQLN.
ProtClustDBPRK05826.

Enzyme and pathway databases

BioCycSTYP99287:STM1888-MONOMER.

Family and domain databases

InterProIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
Gene3DG3DSA:2.40.33.10. PK_B_barrel_like. 1 hit.
G3DSA:3.20.20.60. Pyrv/PenolPyrv_Kinase_cat. 2 hits.
G3DSA:3.40.1380.20. Pyrv_Knase_a/b. 1 hit.
KOK00873.
PANTHERPTHR11817. Pyruvate_kinase. 1 hit.
PfamPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSPR01050. PYRUVTKNASE.
SUPFAMSSF50800. PK_B_barrel_like. 1 hit.
SSF52935. Pyruvate_kinase. 1 hit.
SSF51621. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
TIGRFAMsTIGR01064. Pyruv_kin. 1 hit.
PROSITEPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPYK2_SALTY
AccessionPrimary (citable) accession number: Q8ZNW0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: January 23, 2007
Last modified: January 25, 2012
This is version 59 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents