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Q8ZNT7

- DCYD_SALTY

UniProt

Q8ZNT7 - DCYD_SALTY

Protein

D-cysteine desulfhydrase

Gene

dcyD

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine.UniRule annotation

    Catalytic activityi

    D-cysteine + H2O = H2S + NH3 + pyruvate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. D-cysteine desulfhydrase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-amino acid metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-1964-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D-cysteine desulfhydraseUniRule annotation (EC:4.4.1.15UniRule annotation)
    Gene namesi
    Name:dcyDUniRule annotation
    Ordered Locus Names:STM1953
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 328327D-cysteine desulfhydrasePRO_0000184517Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei51 – 511N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PaxDbiQ8ZNT7.
    PRIDEiQ8ZNT7.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi99287.STM1953.

    Structurei

    Secondary structure

    1
    328
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi4 – 85
    Beta strandi21 – 233
    Helixi25 – 317
    Beta strandi35 – 395
    Helixi40 – 423
    Helixi51 – 6414
    Beta strandi69 – 757
    Helixi79 – 9113
    Beta strandi94 – 1007
    Helixi108 – 1125
    Helixi114 – 1218
    Beta strandi125 – 1284
    Helixi135 – 14814
    Beta strandi153 – 1553
    Helixi158 – 1603
    Helixi163 – 18018
    Turni181 – 1833
    Beta strandi188 – 1969
    Helixi197 – 20913
    Beta strandi213 – 22210
    Helixi224 – 24118
    Beta strandi251 – 2533
    Beta strandi255 – 2573
    Helixi266 – 27914
    Turni285 – 2873
    Helixi288 – 30114
    Beta strandi304 – 3085
    Beta strandi310 – 3145
    Helixi320 – 3245

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4D8TX-ray2.28A/B/C/D1-328[»]
    4D8UX-ray3.30A/B/C/D/E/F/G/H1-328[»]
    4D8WX-ray2.01A/B/C/D1-328[»]
    4D92X-ray2.22A/B/C/D1-328[»]
    4D96X-ray2.09A/B/C/D1-328[»]
    4D97X-ray1.77A/B/C/D1-328[»]
    4D99X-ray2.01A/B/C/D1-328[»]
    4D9BX-ray1.67A/B/C/D1-328[»]
    4D9CX-ray1.97A/B/C/D1-328[»]
    4D9EX-ray2.47A/B/C/D1-328[»]
    4D9FX-ray2.61A/B/C/D1-328[»]
    ProteinModelPortaliQ8ZNT7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ACC deaminase/D-cysteine desulfhydrase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2515.
    HOGENOMiHOG000022459.
    KOiK05396.
    OMAiPYLVPIG.
    OrthoDBiEOG6FBX0P.
    PhylomeDBiQ8ZNT7.

    Family and domain databases

    HAMAPiMF_01045. D_Cys_desulfhydr.
    InterProiIPR027278. ACCD_DCysDesulf.
    IPR005966. D-Cys_desShydrase.
    IPR023702. D_Cys_desulphydr_bac.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view]
    PfamiPF00291. PALP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006278. ACCD_DCysDesulf. 1 hit.
    SUPFAMiSSF53686. SSF53686. 1 hit.
    TIGRFAMsiTIGR01275. ACC_deam_rel. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8ZNT7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLHHLTRFP RLEFIGAPTP LEYLPRLSDY LGREIYIKRD DVTPIAMGGN    50
    KLRKLEFLVA DALREGADTL ITAGAIQSNH VRQTAAVAAK LGLHCVALLE 100
    NPIGTTAENY LTNGNRLLLD LFNTQIEMCD ALTDPDAQLQ TLATRIEAQG 150
    FRPYVIPVGG SSALGAMGYV ESALEIAQQC EEVVGLSSVV VASGSAGTHA 200
    GLAVGLEHLM PDVELIGVTV SRSVAEQKPK VIALQQAIAG QLALTATADI 250
    HLWDDYFAPG YGVPNDAGME AVKLLASLEG VLLDPVYTGK AMAGLIDGIS 300
    QKRFNDDGPI LFIHTGGAPA LFAYHPHV 328
    Length:328
    Mass (Da):34,911
    Last modified:January 23, 2007 - v3
    Checksum:i417DBD984622496B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL20865.1.
    RefSeqiNP_460906.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL20865; AAL20865; STM1953.
    GeneIDi1253474.
    KEGGistm:STM1953.
    PATRICi32382465. VBISalEnt20916_2068.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL20865.1 .
    RefSeqi NP_460906.1. NC_003197.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4D8T X-ray 2.28 A/B/C/D 1-328 [» ]
    4D8U X-ray 3.30 A/B/C/D/E/F/G/H 1-328 [» ]
    4D8W X-ray 2.01 A/B/C/D 1-328 [» ]
    4D92 X-ray 2.22 A/B/C/D 1-328 [» ]
    4D96 X-ray 2.09 A/B/C/D 1-328 [» ]
    4D97 X-ray 1.77 A/B/C/D 1-328 [» ]
    4D99 X-ray 2.01 A/B/C/D 1-328 [» ]
    4D9B X-ray 1.67 A/B/C/D 1-328 [» ]
    4D9C X-ray 1.97 A/B/C/D 1-328 [» ]
    4D9E X-ray 2.47 A/B/C/D 1-328 [» ]
    4D9F X-ray 2.61 A/B/C/D 1-328 [» ]
    ProteinModelPortali Q8ZNT7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM1953.

    Proteomic databases

    PaxDbi Q8ZNT7.
    PRIDEi Q8ZNT7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL20865 ; AAL20865 ; STM1953 .
    GeneIDi 1253474.
    KEGGi stm:STM1953.
    PATRICi 32382465. VBISalEnt20916_2068.

    Phylogenomic databases

    eggNOGi COG2515.
    HOGENOMi HOG000022459.
    KOi K05396.
    OMAi PYLVPIG.
    OrthoDBi EOG6FBX0P.
    PhylomeDBi Q8ZNT7.

    Enzyme and pathway databases

    BioCyci SENT99287:GCTI-1964-MONOMER.

    Family and domain databases

    HAMAPi MF_01045. D_Cys_desulfhydr.
    InterProi IPR027278. ACCD_DCysDesulf.
    IPR005966. D-Cys_desShydrase.
    IPR023702. D_Cys_desulphydr_bac.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view ]
    Pfami PF00291. PALP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006278. ACCD_DCysDesulf. 1 hit.
    SUPFAMi SSF53686. SSF53686. 1 hit.
    TIGRFAMsi TIGR01275. ACC_deam_rel. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.

    Entry informationi

    Entry nameiDCYD_SALTY
    AccessioniPrimary (citable) accession number: Q8ZNT7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 22, 2003
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 70 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3