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Q8ZNT7 (DCYD_SALTY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-cysteine desulfhydrase

EC=4.4.1.15
Gene names
Name:dcyD
Ordered Locus Names:STM1953
OrganismSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]
Taxonomic identifier99287 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine By similarity. HAMAP-Rule MF_01045

Catalytic activity

D-cysteine + H2O = H2S + NH3 + pyruvate. HAMAP-Rule MF_01045

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01045

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01045

Sequence similarities

Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

Ontologies

Keywords
   LigandPyridoxal phosphate
   Molecular functionLyase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processD-amino acid metabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionD-cysteine desulfhydrase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 328327D-cysteine desulfhydrase HAMAP-Rule MF_01045
PRO_0000184517

Amino acid modifications

Modified residue511N6-(pyridoxal phosphate)lysine By similarity

Secondary structure

....................................................... 328
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q8ZNT7 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 417DBD984622496B

FASTA32834,911
        10         20         30         40         50         60 
MPLHHLTRFP RLEFIGAPTP LEYLPRLSDY LGREIYIKRD DVTPIAMGGN KLRKLEFLVA 

        70         80         90        100        110        120 
DALREGADTL ITAGAIQSNH VRQTAAVAAK LGLHCVALLE NPIGTTAENY LTNGNRLLLD 

       130        140        150        160        170        180 
LFNTQIEMCD ALTDPDAQLQ TLATRIEAQG FRPYVIPVGG SSALGAMGYV ESALEIAQQC 

       190        200        210        220        230        240 
EEVVGLSSVV VASGSAGTHA GLAVGLEHLM PDVELIGVTV SRSVAEQKPK VIALQQAIAG 

       250        260        270        280        290        300 
QLALTATADI HLWDDYFAPG YGVPNDAGME AVKLLASLEG VLLDPVYTGK AMAGLIDGIS 

       310        320 
QKRFNDDGPI LFIHTGGAPA LFAYHPHV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006468 Genomic DNA. Translation: AAL20865.1.
RefSeqNP_460906.1. NC_003197.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4D8TX-ray2.28A/B/C/D1-328[»]
4D8UX-ray3.30A/B/C/D/E/F/G/H1-328[»]
4D8WX-ray2.01A/B/C/D1-328[»]
4D92X-ray2.22A/B/C/D1-328[»]
4D96X-ray2.09A/B/C/D1-328[»]
4D97X-ray1.77A/B/C/D1-328[»]
4D99X-ray2.01A/B/C/D1-328[»]
4D9BX-ray1.67A/B/C/D1-328[»]
4D9CX-ray1.97A/B/C/D1-328[»]
4D9EX-ray2.47A/B/C/D1-328[»]
4D9FX-ray2.61A/B/C/D1-328[»]
ProteinModelPortalQ8ZNT7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING99287.STM1953.

Proteomic databases

PaxDbQ8ZNT7.
PRIDEQ8ZNT7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL20865; AAL20865; STM1953.
GeneID1253474.
KEGGstm:STM1953.
PATRIC32382465. VBISalEnt20916_2068.

Phylogenomic databases

eggNOGCOG2515.
HOGENOMHOG000022459.
KOK05396.
OMAPYLVPIG.
OrthoDBEOG6FBX0P.
PhylomeDBQ8ZNT7.

Enzyme and pathway databases

BioCycSENT99287:GCTI-1964-MONOMER.

Family and domain databases

HAMAPMF_01045. D_Cys_desulfhydr.
InterProIPR027278. ACCD_DCysDesulf.
IPR005966. D-Cys_desShydrase.
IPR023702. D_Cys_desulphydr_bac.
IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
[Graphical view]
PfamPF00291. PALP. 1 hit.
[Graphical view]
PIRSFPIRSF006278. ACCD_DCysDesulf. 1 hit.
SUPFAMSSF53686. SSF53686. 1 hit.
TIGRFAMsTIGR01275. ACC_deam_rel. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDCYD_SALTY
AccessionPrimary (citable) accession number: Q8ZNT7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 22, 2003
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 69 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references