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Protein

D-cysteine desulfhydrase

Gene

dcyD

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine.UniRule annotation

Catalytic activityi

D-cysteine + H2O = H2S + NH3 + pyruvate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
D-cysteine desulfhydraseUniRule annotation (EC:4.4.1.15UniRule annotation)
Gene namesi
Name:dcyDUniRule annotation
Ordered Locus Names:STM1953
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001845172 – 328D-cysteine desulfhydraseAdd BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PaxDbiQ8ZNT7.
PRIDEiQ8ZNT7.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi99287.STM1953.

Structurei

Secondary structure

1328
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 8Combined sources5
Beta strandi21 – 23Combined sources3
Helixi25 – 31Combined sources7
Beta strandi35 – 39Combined sources5
Helixi40 – 42Combined sources3
Helixi51 – 64Combined sources14
Beta strandi69 – 75Combined sources7
Helixi79 – 91Combined sources13
Beta strandi94 – 100Combined sources7
Helixi108 – 112Combined sources5
Helixi114 – 121Combined sources8
Beta strandi125 – 128Combined sources4
Helixi135 – 148Combined sources14
Beta strandi153 – 155Combined sources3
Helixi158 – 160Combined sources3
Helixi163 – 180Combined sources18
Turni181 – 183Combined sources3
Beta strandi188 – 196Combined sources9
Helixi197 – 209Combined sources13
Beta strandi213 – 222Combined sources10
Helixi224 – 241Combined sources18
Beta strandi251 – 253Combined sources3
Beta strandi255 – 257Combined sources3
Helixi266 – 279Combined sources14
Turni285 – 287Combined sources3
Helixi288 – 301Combined sources14
Beta strandi304 – 308Combined sources5
Beta strandi310 – 314Combined sources5
Helixi320 – 324Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D8TX-ray2.28A/B/C/D1-328[»]
4D8UX-ray3.30A/B/C/D/E/F/G/H1-328[»]
4D8WX-ray2.01A/B/C/D1-328[»]
4D92X-ray2.22A/B/C/D1-328[»]
4D96X-ray2.09A/B/C/D1-328[»]
4D97X-ray1.77A/B/C/D1-328[»]
4D99X-ray2.01A/B/C/D1-328[»]
4D9BX-ray1.67A/B/C/D1-328[»]
4D9CX-ray1.97A/B/C/D1-328[»]
4D9EX-ray2.47A/B/C/D1-328[»]
4D9FX-ray2.61A/B/C/D1-328[»]
ProteinModelPortaliQ8ZNT7.
SMRiQ8ZNT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ACC deaminase/D-cysteine desulfhydrase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105K6H. Bacteria.
COG2515. LUCA.
HOGENOMiHOG000022459.
KOiK05396.
OMAiTLWDDYF.
PhylomeDBiQ8ZNT7.

Family and domain databases

HAMAPiMF_01045. D_Cys_desulfhydr. 1 hit.
InterProiIPR027278. ACCD_DCysDesulf.
IPR005966. D-Cys_desShydrase.
IPR023702. D_Cys_desulphydr_bac.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF006278. ACCD_DCysDesulf. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR01275. ACC_deam_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8ZNT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLHHLTRFP RLEFIGAPTP LEYLPRLSDY LGREIYIKRD DVTPIAMGGN
60 70 80 90 100
KLRKLEFLVA DALREGADTL ITAGAIQSNH VRQTAAVAAK LGLHCVALLE
110 120 130 140 150
NPIGTTAENY LTNGNRLLLD LFNTQIEMCD ALTDPDAQLQ TLATRIEAQG
160 170 180 190 200
FRPYVIPVGG SSALGAMGYV ESALEIAQQC EEVVGLSSVV VASGSAGTHA
210 220 230 240 250
GLAVGLEHLM PDVELIGVTV SRSVAEQKPK VIALQQAIAG QLALTATADI
260 270 280 290 300
HLWDDYFAPG YGVPNDAGME AVKLLASLEG VLLDPVYTGK AMAGLIDGIS
310 320
QKRFNDDGPI LFIHTGGAPA LFAYHPHV
Length:328
Mass (Da):34,911
Last modified:January 23, 2007 - v3
Checksum:i417DBD984622496B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL20865.1.
RefSeqiNP_460906.1. NC_003197.1.
WP_001128180.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20865; AAL20865; STM1953.
GeneIDi1253474.
KEGGistm:STM1953.
PATRICi32382465. VBISalEnt20916_2068.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL20865.1.
RefSeqiNP_460906.1. NC_003197.1.
WP_001128180.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D8TX-ray2.28A/B/C/D1-328[»]
4D8UX-ray3.30A/B/C/D/E/F/G/H1-328[»]
4D8WX-ray2.01A/B/C/D1-328[»]
4D92X-ray2.22A/B/C/D1-328[»]
4D96X-ray2.09A/B/C/D1-328[»]
4D97X-ray1.77A/B/C/D1-328[»]
4D99X-ray2.01A/B/C/D1-328[»]
4D9BX-ray1.67A/B/C/D1-328[»]
4D9CX-ray1.97A/B/C/D1-328[»]
4D9EX-ray2.47A/B/C/D1-328[»]
4D9FX-ray2.61A/B/C/D1-328[»]
ProteinModelPortaliQ8ZNT7.
SMRiQ8ZNT7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM1953.

Proteomic databases

PaxDbiQ8ZNT7.
PRIDEiQ8ZNT7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL20865; AAL20865; STM1953.
GeneIDi1253474.
KEGGistm:STM1953.
PATRICi32382465. VBISalEnt20916_2068.

Phylogenomic databases

eggNOGiENOG4105K6H. Bacteria.
COG2515. LUCA.
HOGENOMiHOG000022459.
KOiK05396.
OMAiTLWDDYF.
PhylomeDBiQ8ZNT7.

Family and domain databases

HAMAPiMF_01045. D_Cys_desulfhydr. 1 hit.
InterProiIPR027278. ACCD_DCysDesulf.
IPR005966. D-Cys_desShydrase.
IPR023702. D_Cys_desulphydr_bac.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF006278. ACCD_DCysDesulf. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR01275. ACC_deam_rel. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDCYD_SALTY
AccessioniPrimary (citable) accession number: Q8ZNT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2003
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 80 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.