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Q8ZNT7

- DCYD_SALTY

UniProt

Q8ZNT7 - DCYD_SALTY

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Protein

D-cysteine desulfhydrase

Gene

dcyD

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine.UniRule annotation

Catalytic activityi

D-cysteine + H2O = H2S + NH3 + pyruvate.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. D-cysteine desulfhydrase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-amino acid metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1964-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
D-cysteine desulfhydraseUniRule annotation (EC:4.4.1.15UniRule annotation)
Gene namesi
Name:dcyDUniRule annotation
Ordered Locus Names:STM1953
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 328327D-cysteine desulfhydrasePRO_0000184517Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 511N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PaxDbiQ8ZNT7.
PRIDEiQ8ZNT7.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi99287.STM1953.

Structurei

Secondary structure

1
328
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 85
Beta strandi21 – 233
Helixi25 – 317
Beta strandi35 – 395
Helixi40 – 423
Helixi51 – 6414
Beta strandi69 – 757
Helixi79 – 9113
Beta strandi94 – 1007
Helixi108 – 1125
Helixi114 – 1218
Beta strandi125 – 1284
Helixi135 – 14814
Beta strandi153 – 1553
Helixi158 – 1603
Helixi163 – 18018
Turni181 – 1833
Beta strandi188 – 1969
Helixi197 – 20913
Beta strandi213 – 22210
Helixi224 – 24118
Beta strandi251 – 2533
Beta strandi255 – 2573
Helixi266 – 27914
Turni285 – 2873
Helixi288 – 30114
Beta strandi304 – 3085
Beta strandi310 – 3145
Helixi320 – 3245

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4D8TX-ray2.28A/B/C/D1-328[»]
4D8UX-ray3.30A/B/C/D/E/F/G/H1-328[»]
4D8WX-ray2.01A/B/C/D1-328[»]
4D92X-ray2.22A/B/C/D1-328[»]
4D96X-ray2.09A/B/C/D1-328[»]
4D97X-ray1.77A/B/C/D1-328[»]
4D99X-ray2.01A/B/C/D1-328[»]
4D9BX-ray1.67A/B/C/D1-328[»]
4D9CX-ray1.97A/B/C/D1-328[»]
4D9EX-ray2.47A/B/C/D1-328[»]
4D9FX-ray2.61A/B/C/D1-328[»]
ProteinModelPortaliQ8ZNT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ACC deaminase/D-cysteine desulfhydrase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2515.
HOGENOMiHOG000022459.
KOiK05396.
OMAiPYLVPIG.
OrthoDBiEOG6FBX0P.
PhylomeDBiQ8ZNT7.

Family and domain databases

HAMAPiMF_01045. D_Cys_desulfhydr.
InterProiIPR027278. ACCD_DCysDesulf.
IPR005966. D-Cys_desShydrase.
IPR023702. D_Cys_desulphydr_bac.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF006278. ACCD_DCysDesulf. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR01275. ACC_deam_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8ZNT7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLHHLTRFP RLEFIGAPTP LEYLPRLSDY LGREIYIKRD DVTPIAMGGN
60 70 80 90 100
KLRKLEFLVA DALREGADTL ITAGAIQSNH VRQTAAVAAK LGLHCVALLE
110 120 130 140 150
NPIGTTAENY LTNGNRLLLD LFNTQIEMCD ALTDPDAQLQ TLATRIEAQG
160 170 180 190 200
FRPYVIPVGG SSALGAMGYV ESALEIAQQC EEVVGLSSVV VASGSAGTHA
210 220 230 240 250
GLAVGLEHLM PDVELIGVTV SRSVAEQKPK VIALQQAIAG QLALTATADI
260 270 280 290 300
HLWDDYFAPG YGVPNDAGME AVKLLASLEG VLLDPVYTGK AMAGLIDGIS
310 320
QKRFNDDGPI LFIHTGGAPA LFAYHPHV
Length:328
Mass (Da):34,911
Last modified:January 23, 2007 - v3
Checksum:i417DBD984622496B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL20865.1.
RefSeqiNP_460906.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20865; AAL20865; STM1953.
GeneIDi1253474.
KEGGistm:STM1953.
PATRICi32382465. VBISalEnt20916_2068.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL20865.1 .
RefSeqi NP_460906.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4D8T X-ray 2.28 A/B/C/D 1-328 [» ]
4D8U X-ray 3.30 A/B/C/D/E/F/G/H 1-328 [» ]
4D8W X-ray 2.01 A/B/C/D 1-328 [» ]
4D92 X-ray 2.22 A/B/C/D 1-328 [» ]
4D96 X-ray 2.09 A/B/C/D 1-328 [» ]
4D97 X-ray 1.77 A/B/C/D 1-328 [» ]
4D99 X-ray 2.01 A/B/C/D 1-328 [» ]
4D9B X-ray 1.67 A/B/C/D 1-328 [» ]
4D9C X-ray 1.97 A/B/C/D 1-328 [» ]
4D9E X-ray 2.47 A/B/C/D 1-328 [» ]
4D9F X-ray 2.61 A/B/C/D 1-328 [» ]
ProteinModelPortali Q8ZNT7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM1953.

Proteomic databases

PaxDbi Q8ZNT7.
PRIDEi Q8ZNT7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL20865 ; AAL20865 ; STM1953 .
GeneIDi 1253474.
KEGGi stm:STM1953.
PATRICi 32382465. VBISalEnt20916_2068.

Phylogenomic databases

eggNOGi COG2515.
HOGENOMi HOG000022459.
KOi K05396.
OMAi PYLVPIG.
OrthoDBi EOG6FBX0P.
PhylomeDBi Q8ZNT7.

Enzyme and pathway databases

BioCyci SENT99287:GCTI-1964-MONOMER.

Family and domain databases

HAMAPi MF_01045. D_Cys_desulfhydr.
InterProi IPR027278. ACCD_DCysDesulf.
IPR005966. D-Cys_desShydrase.
IPR023702. D_Cys_desulphydr_bac.
IPR001926. TrpB-like_PLP-dep.
[Graphical view ]
Pfami PF00291. PALP. 1 hit.
[Graphical view ]
PIRSFi PIRSF006278. ACCD_DCysDesulf. 1 hit.
SUPFAMi SSF53686. SSF53686. 1 hit.
TIGRFAMsi TIGR01275. ACC_deam_rel. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiDCYD_SALTY
AccessioniPrimary (citable) accession number: Q8ZNT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2003
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 71 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3