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Q8ZMH3

- PRP2_SALTY

UniProt

Q8ZMH3 - PRP2_SALTY

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Protein
Serine/threonine-protein phosphatase 2
Gene
pphB, prpB, STM2907
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Can hydrolyze phosphorylated Ser-, Thr- or Tyr-substrates in vitro. The natural substrate is unknown.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Manganese.

Enzyme regulationi

Inhibited by cadmium, copper, zinc when added activity but with less efficiency.

pH dependencei

Optimum pH is 7.5-8.5.

Temperature dependencei

Optimum temperature is 30-37 degrees Celsius.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi22 – 221Manganese 1 By similarity
Metal bindingi24 – 241Manganese 1 By similarity
Metal bindingi51 – 511Manganese 1 By similarity
Metal bindingi51 – 511Manganese 2 By similarity
Metal bindingi77 – 771Manganese 2 By similarity
Active sitei78 – 781Proton donor By similarity
Metal bindingi187 – 1871Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciSENT99287:GCTI-2923-MONOMER.

Protein family/group databases

PptaseDBiP3D0411149.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2 (EC:3.1.3.16)
Gene namesi
Name:pphB
Synonyms:prpB
Ordered Locus Names:STM2907
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Serine/threonine-protein phosphatase 2
PRO_0000058911Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi99287.STM2907.

Structurei

3D structure databases

ProteinModelPortaliQ8ZMH3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000251869.
KOiK07314.
OMAiGDWFFEL.
OrthoDBiEOG6KDKSC.
PhylomeDBiQ8ZMH3.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZMH3-1 [UniParc]FASTAAdd to Basket

« Hide

MELIRYADIN SDLYRHIWVV GDIHGCYSLL LTRLAQLNFS PDTDLLISTG    50
DNIDRGKENL ETLRLLNTPW FISVVGNHEA MALDAFETQD GNFWYVNGGY 100
WYDSVTEKDR QEATELLLTF KQRPHIIEVE TSSKKYVIAH ADYPDDSYDY 150
GKQVDIDSVL WSRDRLLGSL QGNIHPIRGA DTFIFGHMIV DYTTTFANQI 200
YIDTGSFCSG NLSFFKIK 218
Length:218
Mass (Da):25,025
Last modified:March 1, 2002 - v1
Checksum:i723B98837426E350
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY049951 Genomic DNA. Translation: AAL09832.1.
AE006468 Genomic DNA. Translation: AAL21787.1.
RefSeqiNP_461828.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL21787; AAL21787; STM2907.
GeneIDi1254430.
KEGGistm:STM2907.
PATRICi32384498. VBISalEnt20916_3061.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY049951 Genomic DNA. Translation: AAL09832.1 .
AE006468 Genomic DNA. Translation: AAL21787.1 .
RefSeqi NP_461828.1. NC_003197.1.

3D structure databases

ProteinModelPortali Q8ZMH3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM2907.

Protein family/group databases

PptaseDBi P3D0411149.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL21787 ; AAL21787 ; STM2907 .
GeneIDi 1254430.
KEGGi stm:STM2907.
PATRICi 32384498. VBISalEnt20916_3061.

Phylogenomic databases

eggNOGi COG0639.
HOGENOMi HOG000251869.
KOi K07314.
OMAi GDWFFEL.
OrthoDBi EOG6KDKSC.
PhylomeDBi Q8ZMH3.

Enzyme and pathway databases

BioCyci SENT99287:GCTI-2923-MONOMER.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The PPP-family protein phosphatases PrpA and PrpB of Salmonella enterica serovar Typhimurium possess distinct biochemical properties."
    Shi L., Kehres D.G., Maguire M.E.
    J. Bacteriol. 183:7053-7057(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiPRP2_SALTY
AccessioniPrimary (citable) accession number: Q8ZMH3
Secondary accession number(s): Q79S89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Neither magnesium nor calcium stimulates activity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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