Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein phosphatase 2

Gene

pphB

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Can hydrolyze phosphorylated Ser-, Thr- or Tyr-substrates in vitro. The natural substrate is unknown.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Enzyme regulationi

Inhibited by cadmium, copper, zinc when added activity but with less efficiency.

pH dependencei

Optimum pH is 7.5-8.5.

Temperature dependencei

Optimum temperature is 30-37 degrees Celsius.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi22Manganese 1By similarity1
Metal bindingi24Manganese 1By similarity1
Metal bindingi51Manganese 1By similarity1
Metal bindingi51Manganese 2By similarity1
Metal bindingi77Manganese 2By similarity1
Active sitei78Proton donorBy similarity1
Metal bindingi187Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2 (EC:3.1.3.16)
Gene namesi
Name:pphB
Synonyms:prpB
Ordered Locus Names:STM2907
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000589111 – 218Serine/threonine-protein phosphatase 2Add BLAST218

Proteomic databases

PaxDbiQ8ZMH3.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM2907.

Structurei

3D structure databases

ProteinModelPortaliQ8ZMH3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105MEW. Bacteria.
COG0639. LUCA.
HOGENOMiHOG000251869.
KOiK07314.
OMAiNTSWFIS.
PhylomeDBiQ8ZMH3.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZMH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELIRYADIN SDLYRHIWVV GDIHGCYSLL LTRLAQLNFS PDTDLLISTG
60 70 80 90 100
DNIDRGKENL ETLRLLNTPW FISVVGNHEA MALDAFETQD GNFWYVNGGY
110 120 130 140 150
WYDSVTEKDR QEATELLLTF KQRPHIIEVE TSSKKYVIAH ADYPDDSYDY
160 170 180 190 200
GKQVDIDSVL WSRDRLLGSL QGNIHPIRGA DTFIFGHMIV DYTTTFANQI
210
YIDTGSFCSG NLSFFKIK
Length:218
Mass (Da):25,025
Last modified:March 1, 2002 - v1
Checksum:i723B98837426E350
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049951 Genomic DNA. Translation: AAL09832.1.
AE006468 Genomic DNA. Translation: AAL21787.1.
RefSeqiNP_461828.1. NC_003197.1.
WP_000420452.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL21787; AAL21787; STM2907.
GeneIDi1254430.
KEGGistm:STM2907.
PATRICi32384498. VBISalEnt20916_3061.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049951 Genomic DNA. Translation: AAL09832.1.
AE006468 Genomic DNA. Translation: AAL21787.1.
RefSeqiNP_461828.1. NC_003197.1.
WP_000420452.1. NC_003197.1.

3D structure databases

ProteinModelPortaliQ8ZMH3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM2907.

Proteomic databases

PaxDbiQ8ZMH3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL21787; AAL21787; STM2907.
GeneIDi1254430.
KEGGistm:STM2907.
PATRICi32384498. VBISalEnt20916_3061.

Phylogenomic databases

eggNOGiENOG4105MEW. Bacteria.
COG0639. LUCA.
HOGENOMiHOG000251869.
KOiK07314.
OMAiNTSWFIS.
PhylomeDBiQ8ZMH3.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPRP2_SALTY
AccessioniPrimary (citable) accession number: Q8ZMH3
Secondary accession number(s): Q79S89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Neither magnesium nor calcium stimulates activity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.