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Protein

Serine/threonine-protein phosphatase 2

Gene

pphB

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Can hydrolyze phosphorylated Ser-, Thr- or Tyr-substrates in vitro. The natural substrate is unknown.

Miscellaneous

Neither magnesium nor calcium stimulates activity.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Enzyme regulationi

Inhibited by cadmium, copper, zinc when added activity but with less efficiency.

pH dependencei

Optimum pH is 7.5-8.5.

Temperature dependencei

Optimum temperature is 30-37 degrees Celsius.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi22Manganese 1By similarity1
Metal bindingi24Manganese 1By similarity1
Metal bindingi51Manganese 1By similarity1
Metal bindingi51Manganese 2By similarity1
Metal bindingi77Manganese 2By similarity1
Active sitei78Proton donorBy similarity1
Metal bindingi187Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-2935-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2 (EC:3.1.3.16)
Gene namesi
Name:pphB
Synonyms:prpB
Ordered Locus Names:STM2907
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000589111 – 218Serine/threonine-protein phosphatase 2Add BLAST218

Proteomic databases

PaxDbiQ8ZMH3

Interactioni

Protein-protein interaction databases

STRINGi99287.STM2907

Structurei

3D structure databases

ProteinModelPortaliQ8ZMH3
SMRiQ8ZMH3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105MEW Bacteria
COG0639 LUCA
HOGENOMiHOG000251869
KOiK07314
OMAiTFANQVY
PhylomeDBiQ8ZMH3

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZMH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELIRYADIN SDLYRHIWVV GDIHGCYSLL LTRLAQLNFS PDTDLLISTG
60 70 80 90 100
DNIDRGKENL ETLRLLNTPW FISVVGNHEA MALDAFETQD GNFWYVNGGY
110 120 130 140 150
WYDSVTEKDR QEATELLLTF KQRPHIIEVE TSSKKYVIAH ADYPDDSYDY
160 170 180 190 200
GKQVDIDSVL WSRDRLLGSL QGNIHPIRGA DTFIFGHMIV DYTTTFANQI
210
YIDTGSFCSG NLSFFKIK
Length:218
Mass (Da):25,025
Last modified:March 1, 2002 - v1
Checksum:i723B98837426E350
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049951 Genomic DNA Translation: AAL09832.1
AE006468 Genomic DNA Translation: AAL21787.1
RefSeqiNP_461828.1, NC_003197.2
WP_000420452.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL21787; AAL21787; STM2907
GeneIDi1254430
KEGGistm:STM2907
PATRICifig|99287.12.peg.3061

Similar proteinsi

Entry informationi

Entry nameiPRP2_SALTY
AccessioniPrimary (citable) accession number: Q8ZMH3
Secondary accession number(s): Q79S89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health