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Q8ZMH3

- PRP2_SALTY

UniProt

Q8ZMH3 - PRP2_SALTY

Protein

Serine/threonine-protein phosphatase 2

Gene

pphB

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Can hydrolyze phosphorylated Ser-, Thr- or Tyr-substrates in vitro. The natural substrate is unknown.

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Manganese.

    Enzyme regulationi

    Inhibited by cadmium, copper, zinc when added activity but with less efficiency.

    pH dependencei

    Optimum pH is 7.5-8.5.

    Temperature dependencei

    Optimum temperature is 30-37 degrees Celsius.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi22 – 221Manganese 1By similarity
    Metal bindingi24 – 241Manganese 1By similarity
    Metal bindingi51 – 511Manganese 1By similarity
    Metal bindingi51 – 511Manganese 2By similarity
    Metal bindingi77 – 771Manganese 2By similarity
    Active sitei78 – 781Proton donorBy similarity
    Metal bindingi187 – 1871Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-2923-MONOMER.

    Protein family/group databases

    PptaseDBiP3D0411149.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase 2 (EC:3.1.3.16)
    Gene namesi
    Name:pphB
    Synonyms:prpB
    Ordered Locus Names:STM2907
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 218218Serine/threonine-protein phosphatase 2PRO_0000058911Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi99287.STM2907.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8ZMH3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0639.
    HOGENOMiHOG000251869.
    KOiK07314.
    OMAiGDWFFEL.
    OrthoDBiEOG6KDKSC.
    PhylomeDBiQ8ZMH3.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8ZMH3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELIRYADIN SDLYRHIWVV GDIHGCYSLL LTRLAQLNFS PDTDLLISTG    50
    DNIDRGKENL ETLRLLNTPW FISVVGNHEA MALDAFETQD GNFWYVNGGY 100
    WYDSVTEKDR QEATELLLTF KQRPHIIEVE TSSKKYVIAH ADYPDDSYDY 150
    GKQVDIDSVL WSRDRLLGSL QGNIHPIRGA DTFIFGHMIV DYTTTFANQI 200
    YIDTGSFCSG NLSFFKIK 218
    Length:218
    Mass (Da):25,025
    Last modified:March 1, 2002 - v1
    Checksum:i723B98837426E350
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY049951 Genomic DNA. Translation: AAL09832.1.
    AE006468 Genomic DNA. Translation: AAL21787.1.
    RefSeqiNP_461828.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL21787; AAL21787; STM2907.
    GeneIDi1254430.
    KEGGistm:STM2907.
    PATRICi32384498. VBISalEnt20916_3061.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY049951 Genomic DNA. Translation: AAL09832.1 .
    AE006468 Genomic DNA. Translation: AAL21787.1 .
    RefSeqi NP_461828.1. NC_003197.1.

    3D structure databases

    ProteinModelPortali Q8ZMH3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM2907.

    Protein family/group databases

    PptaseDBi P3D0411149.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL21787 ; AAL21787 ; STM2907 .
    GeneIDi 1254430.
    KEGGi stm:STM2907.
    PATRICi 32384498. VBISalEnt20916_3061.

    Phylogenomic databases

    eggNOGi COG0639.
    HOGENOMi HOG000251869.
    KOi K07314.
    OMAi GDWFFEL.
    OrthoDBi EOG6KDKSC.
    PhylomeDBi Q8ZMH3.

    Enzyme and pathway databases

    BioCyci SENT99287:GCTI-2923-MONOMER.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The PPP-family protein phosphatases PrpA and PrpB of Salmonella enterica serovar Typhimurium possess distinct biochemical properties."
      Shi L., Kehres D.G., Maguire M.E.
      J. Bacteriol. 183:7053-7057(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.

    Entry informationi

    Entry nameiPRP2_SALTY
    AccessioniPrimary (citable) accession number: Q8ZMH3
    Secondary accession number(s): Q79S89
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Neither magnesium nor calcium stimulates activity.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3