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Q8ZMH3

- PRP2_SALTY

UniProt

Q8ZMH3 - PRP2_SALTY

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Protein

Serine/threonine-protein phosphatase 2

Gene

pphB

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Can hydrolyze phosphorylated Ser-, Thr- or Tyr-substrates in vitro. The natural substrate is unknown.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Manganese.

Enzyme regulationi

Inhibited by cadmium, copper, zinc when added activity but with less efficiency.

pH dependencei

Optimum pH is 7.5-8.5.

Temperature dependencei

Optimum temperature is 30-37 degrees Celsius.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi22 – 221Manganese 1By similarity
Metal bindingi24 – 241Manganese 1By similarity
Metal bindingi51 – 511Manganese 1By similarity
Metal bindingi51 – 511Manganese 2By similarity
Metal bindingi77 – 771Manganese 2By similarity
Active sitei78 – 781Proton donorBy similarity
Metal bindingi187 – 1871Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciSENT99287:GCTI-2923-MONOMER.

Protein family/group databases

PptaseDBiP3D0411149.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2 (EC:3.1.3.16)
Gene namesi
Name:pphB
Synonyms:prpB
Ordered Locus Names:STM2907
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Serine/threonine-protein phosphatase 2PRO_0000058911Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi99287.STM2907.

Structurei

3D structure databases

ProteinModelPortaliQ8ZMH3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000251869.
KOiK07314.
OMAiGDWFFEL.
OrthoDBiEOG6KDKSC.
PhylomeDBiQ8ZMH3.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZMH3 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELIRYADIN SDLYRHIWVV GDIHGCYSLL LTRLAQLNFS PDTDLLISTG
60 70 80 90 100
DNIDRGKENL ETLRLLNTPW FISVVGNHEA MALDAFETQD GNFWYVNGGY
110 120 130 140 150
WYDSVTEKDR QEATELLLTF KQRPHIIEVE TSSKKYVIAH ADYPDDSYDY
160 170 180 190 200
GKQVDIDSVL WSRDRLLGSL QGNIHPIRGA DTFIFGHMIV DYTTTFANQI
210
YIDTGSFCSG NLSFFKIK
Length:218
Mass (Da):25,025
Last modified:March 1, 2002 - v1
Checksum:i723B98837426E350
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY049951 Genomic DNA. Translation: AAL09832.1.
AE006468 Genomic DNA. Translation: AAL21787.1.
RefSeqiNP_461828.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL21787; AAL21787; STM2907.
GeneIDi1254430.
KEGGistm:STM2907.
PATRICi32384498. VBISalEnt20916_3061.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY049951 Genomic DNA. Translation: AAL09832.1 .
AE006468 Genomic DNA. Translation: AAL21787.1 .
RefSeqi NP_461828.1. NC_003197.1.

3D structure databases

ProteinModelPortali Q8ZMH3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM2907.

Protein family/group databases

PptaseDBi P3D0411149.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL21787 ; AAL21787 ; STM2907 .
GeneIDi 1254430.
KEGGi stm:STM2907.
PATRICi 32384498. VBISalEnt20916_3061.

Phylogenomic databases

eggNOGi COG0639.
HOGENOMi HOG000251869.
KOi K07314.
OMAi GDWFFEL.
OrthoDBi EOG6KDKSC.
PhylomeDBi Q8ZMH3.

Enzyme and pathway databases

BioCyci SENT99287:GCTI-2923-MONOMER.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The PPP-family protein phosphatases PrpA and PrpB of Salmonella enterica serovar Typhimurium possess distinct biochemical properties."
    Shi L., Kehres D.G., Maguire M.E.
    J. Bacteriol. 183:7053-7057(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiPRP2_SALTY
AccessioniPrimary (citable) accession number: Q8ZMH3
Secondary accession number(s): Q79S89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2002
Last modified: October 1, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Neither magnesium nor calcium stimulates activity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3