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Protein

Amino-acid acetyltransferase

Gene

argA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate.

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Amino-acid acetyltransferase (argA)
  2. Acetylglutamate kinase (argB)
  3. N-acetyl-gamma-glutamyl-phosphate reductase (argC)
  4. Acetylornithine/succinyldiaminopimelate aminotransferase (argD)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciSENT99287:GCTI-3009-MONOMER.
UniPathwayiUPA00068; UER00106.

Names & Taxonomyi

Protein namesi
Recommended name:
Amino-acid acetyltransferase (EC:2.3.1.1)
Alternative name(s):
N-acetylglutamate synthase
Short name:
AGS
Short name:
NAGS
Gene namesi
Name:argA
Ordered Locus Names:STM2992
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Amino-acid acetyltransferasePRO_0000186805Add
BLAST

Proteomic databases

PaxDbiQ8ZMB8.
PRIDEiQ8ZMB8.

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi99287.STM2992.

Structurei

3D structure databases

ProteinModelPortaliQ8ZMB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini296 – 443148N-acetyltransferaseAdd
BLAST

Sequence similaritiesi

Contains 1 N-acetyltransferase domain.Curated

Phylogenomic databases

eggNOGiENOG4108EKC. Bacteria.
COG0548. LUCA.
COG1246. LUCA.
HOGENOMiHOG000262225.
KOiK14682.
OMAiKQALYNY.
OrthoDBiEOG6T1WVF.
PhylomeDBiQ8ZMB8.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
3.40.630.30. 1 hit.
HAMAPiMF_01105. N_acetyl_glu_synth.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR000182. GNAT_dom.
IPR010167. NH2A_AcTrfase_ArgA.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
PF00583. Acetyltransf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000423. ArgA. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
SSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR01890. N-Ac-Glu-synth. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZMB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKERKTELV EGFRHSVPYI NTHRGKTFVI MLGGEAIEHD NFSSIVSDIG
60 70 80 90 100
LLHSLGIRLV VVYGARPQID ANLAAHHHEP IYHKNTRVTD AKALELVKQA
110 120 130 140 150
AGLLQLDITA RLSMSLNNTP LQGAHINVVS GNFTIAQPLG VDDGVDYCHS
160 170 180 190 200
GRIRRIDEDA INRQLDNGAI VLMGPVAVSV TGESFNLTSE EIATQLAVKL
210 220 230 240 250
KAEKMIGFCS SQGVTNSEGG IISELFPNEA QARVEELEAQ GDYNSGTVRF
260 270 280 290 300
LRGAVKACRS GVRRCHLISY QEDGSLLQEL FSRDGIGTQI VMESAEQIRR
310 320 330 340 350
ATINDIGGIL ELIRPLEQQG ILVRRSREQL EMEIDKFTII QRDNMTIACA
360 370 380 390 400
ALYPFVEEKI GEMACVAVHP DYRSSSRGEV LLERVAAQAR QMGLRKLFVL
410 420 430 440
TTRSIHWFQE RGFTPVDIEL LPESKKKMYN YQRRSKVLMA DLG
Length:443
Mass (Da):49,278
Last modified:March 1, 2002 - v1
Checksum:i7400B522E653EAD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL21868.1.
PIRiS12388.
RefSeqiNP_461909.1. NC_003197.1.
WP_000588964.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL21868; AAL21868; STM2992.
GeneIDi1254515.
KEGGistm:STM2992.
PATRICi32384713. VBISalEnt20916_3166.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL21868.1.
PIRiS12388.
RefSeqiNP_461909.1. NC_003197.1.
WP_000588964.1. NC_003197.1.

3D structure databases

ProteinModelPortaliQ8ZMB8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM2992.

Proteomic databases

PaxDbiQ8ZMB8.
PRIDEiQ8ZMB8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL21868; AAL21868; STM2992.
GeneIDi1254515.
KEGGistm:STM2992.
PATRICi32384713. VBISalEnt20916_3166.

Phylogenomic databases

eggNOGiENOG4108EKC. Bacteria.
COG0548. LUCA.
COG1246. LUCA.
HOGENOMiHOG000262225.
KOiK14682.
OMAiKQALYNY.
OrthoDBiEOG6T1WVF.
PhylomeDBiQ8ZMB8.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00106.
BioCyciSENT99287:GCTI-3009-MONOMER.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
3.40.630.30. 1 hit.
HAMAPiMF_01105. N_acetyl_glu_synth.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR000182. GNAT_dom.
IPR010167. NH2A_AcTrfase_ArgA.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
PF00583. Acetyltransf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000423. ArgA. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
SSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR01890. N-Ac-Glu-synth. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiARGA_SALTY
AccessioniPrimary (citable) accession number: Q8ZMB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: March 1, 2002
Last modified: November 11, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.