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Protein

Amino-acid acetyltransferase

Gene

argA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate.

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Amino-acid acetyltransferase (argA)
  2. Acetylglutamate kinase (argB)
  3. N-acetyl-gamma-glutamyl-phosphate reductase (argC)
  4. Acetylornithine/succinyldiaminopimelate aminotransferase (argD)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-3021-MONOMER
UniPathwayiUPA00068; UER00106

Names & Taxonomyi

Protein namesi
Recommended name:
Amino-acid acetyltransferase (EC:2.3.1.1)
Alternative name(s):
N-acetylglutamate synthase
Short name:
AGS
Short name:
NAGS
Gene namesi
Name:argA
Ordered Locus Names:STM2992
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001868051 – 443Amino-acid acetyltransferaseAdd BLAST443

Proteomic databases

PaxDbiQ8ZMB8
PRIDEiQ8ZMB8

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi99287.STM2992

Structurei

3D structure databases

ProteinModelPortaliQ8ZMB8
SMRiQ8ZMB8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini296 – 443N-acetyltransferaseAdd BLAST148

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108EKC Bacteria
COG0548 LUCA
COG1246 LUCA
HOGENOMiHOG000262225
KOiK14682
OMAiKRKYNWD
PhylomeDBiQ8ZMB8

Family and domain databases

CDDicd04237 AAK_NAGS-ABP, 1 hit
Gene3Di3.40.1160.10, 1 hit
HAMAPiMF_01105 N_acetyl_glu_synth, 1 hit
InterProiView protein in InterPro
IPR036393 AceGlu_kinase-like_sf
IPR016181 Acyl_CoA_acyltransferase
IPR001048 Asp/Glu/Uridylate_kinase
IPR000182 GNAT_dom
IPR033719 NAGS_kin
IPR010167 NH2A_AcTrfase
PANTHERiPTHR30602 PTHR30602, 1 hit
PfamiView protein in Pfam
PF00696 AA_kinase, 1 hit
PF00583 Acetyltransf_1, 1 hit
PIRSFiPIRSF000423 ArgA, 1 hit
SUPFAMiSSF53633 SSF53633, 1 hit
SSF55729 SSF55729, 1 hit
TIGRFAMsiTIGR01890 N-Ac-Glu-synth, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZMB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKERKTELV EGFRHSVPYI NTHRGKTFVI MLGGEAIEHD NFSSIVSDIG
60 70 80 90 100
LLHSLGIRLV VVYGARPQID ANLAAHHHEP IYHKNTRVTD AKALELVKQA
110 120 130 140 150
AGLLQLDITA RLSMSLNNTP LQGAHINVVS GNFTIAQPLG VDDGVDYCHS
160 170 180 190 200
GRIRRIDEDA INRQLDNGAI VLMGPVAVSV TGESFNLTSE EIATQLAVKL
210 220 230 240 250
KAEKMIGFCS SQGVTNSEGG IISELFPNEA QARVEELEAQ GDYNSGTVRF
260 270 280 290 300
LRGAVKACRS GVRRCHLISY QEDGSLLQEL FSRDGIGTQI VMESAEQIRR
310 320 330 340 350
ATINDIGGIL ELIRPLEQQG ILVRRSREQL EMEIDKFTII QRDNMTIACA
360 370 380 390 400
ALYPFVEEKI GEMACVAVHP DYRSSSRGEV LLERVAAQAR QMGLRKLFVL
410 420 430 440
TTRSIHWFQE RGFTPVDIEL LPESKKKMYN YQRRSKVLMA DLG
Length:443
Mass (Da):49,278
Last modified:March 1, 2002 - v1
Checksum:i7400B522E653EAD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA Translation: AAL21868.1
PIRiS12388
RefSeqiNP_461909.1, NC_003197.2
WP_000588964.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL21868; AAL21868; STM2992
GeneIDi1254515
KEGGistm:STM2992
PATRICifig|99287.12.peg.3166

Similar proteinsi

Entry informationi

Entry nameiARGA_SALTY
AccessioniPrimary (citable) accession number: Q8ZMB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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