Reviewed, UniProtKB/Swiss-Prot Q8ZMB8 (ARGA_SALTY)

Names and origin

Protein names

Recommended name:
    Amino-acid acetyltransferase
    EC=2.3.1.1
Alternative name(s):
    N-acetylglutamate synthase
      Short name=AGS
      Short name=NAGS

Gene names

Name:	argA
Ordered Locus Names:	STM2992

Organism

Salmonella typhimurium [Complete proteome] [HAMAP]

Taxonomic identifier

90371 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	443 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate. HAMAP MF_01105
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4. HAMAP MF_01105
Subunit structure	Homohexamer Probable.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the acetyltransferase family. ArgA subfamily. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	amino-acid N-acetyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 443	443	Amino-acid acetyltransferase HAMAP MF_01105		PRO_0000186805
Regions
	Domain	296 – 443	148	N-acetyltransferase

Sequences

	Sequence		Length	Mass (Da)
	Q8ZMB8-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 7400B522E653EAD9	FASTA	443	49,278
	10 20 30 40 50 60 MIKERKTELV EGFRHSVPYI NTHRGKTFVI MLGGEAIEHD NFSSIVSDIG LLHSLGIRLV 70 80 90 100 110 120 VVYGARPQID ANLAAHHHEP IYHKNTRVTD AKALELVKQA AGLLQLDITA RLSMSLNNTP 130 140 150 160 170 180 LQGAHINVVS GNFTIAQPLG VDDGVDYCHS GRIRRIDEDA INRQLDNGAI VLMGPVAVSV 190 200 210 220 230 240 TGESFNLTSE EIATQLAVKL KAEKMIGFCS SQGVTNSEGG IISELFPNEA QARVEELEAQ 250 260 270 280 290 300 GDYNSGTVRF LRGAVKACRS GVRRCHLISY QEDGSLLQEL FSRDGIGTQI VMESAEQIRR 310 320 330 340 350 360 ATINDIGGIL ELIRPLEQQG ILVRRSREQL EMEIDKFTII QRDNMTIACA ALYPFVEEKI 370 380 390 400 410 420 GEMACVAVHP DYRSSSRGEV LLERVAAQAR QMGLRKLFVL TTRSIHWFQE RGFTPVDIEL 430 440 LPESKKKMYN YQRRSKVLMA DLG

References

[1]

"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE006468 Genomic DNA. Translation: AAL21868.1.
PIR	S12388.
RefSeq	NP_461909.1.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q8ZMB8.
Genome annotation databases
GeneID	1254515.
GenomeReviews	Gene locus STM2992 in contig AE006468_GR.
KEGG	stm:STM2992.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8ZMB8.
OMA	DLIRPLE.
Enzyme and pathway databases
BioCyc	STYP99287:STM2992-MON.
BRENDA	2.3.1.1. 2.
Family and domain databases
HAMAP	MF_01105. [Tree]
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR001048. Asp/Glu/Uridylate_kinase. IPR000182. GCN5-rel_AcTrfase. IPR010167. NH2A_AcTrfase_ArgA. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit. G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit.
Pfam	PF00696. AA_kinase. 1 hit. PF00583. Acetyltransf_1. 1 hit. [Graphical view]
PIRSF	PIRSF000423. ArgA. 1 hit.
TIGRFAMs	TIGR01890. N-Ac-Glu-synth. 1 hit.
PROSITE	PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGA_SALTY

Accession

Primary (citable) accession number: Q8ZMB8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 12, 2003
Last sequence update:	March 1, 2002
Last modified:	November 3, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)