Q8ZM76 (GCSP_SALTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycine dehydrogenase [decarboxylating]
EC=1.4.4.2

Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase

Gene names

Name:	gcvP
Ordered Locus Names:	STM3053

Organism

Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]

Taxonomic identifier

99287 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella › Salmonella choleraesuis › Salmonella enterica I › Salmonella typhimurium

Protein attributes

Sequence length	957 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP-Rule MF_00711
Cofactor	Pyridoxal phosphate By similarity.
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvP family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP
Molecular_function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 957	956	Glycine dehydrogenase [decarboxylating] HAMAP-Rule MF_00711		PRO_0000166935
Amino acid modifications
	Modified residue	708	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8ZM76 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 31B41A0588DE9E8C	FASTA	957	104,287
	10 20 30 40 50 60 MTQTLSQLEN RGAFIERHIG PDAAQQQEML NAVGAESLNA LTGQIVPKDI QLATPPQVGE 70 80 90 100 110 120 AATEYAALAE LKAIAGRNKR FTSYIGMGYT AVQLPPVILR NMLENPGWYT AYTPYQPEVS 130 140 150 160 170 180 QGRLEALLNF QQVTLDLTGL DMASASLLDE ATAAAEAMAM AKRVSKLKNA NRFFVASDVH 190 200 210 220 230 240 PQTLDVVRTR AETFGFDVIV DDAAKALDHQ DVFGVLLQQV GTTGEIHDYS ALITELKSRK 250 260 270 280 290 300 VVVSVAADFM ALVLLTAPGK QGADIVFGSA QRFGVPMGYG GPHAAFFAAK DEFKRSMPGR 310 320 330 340 350 360 IIGVSKDAAG NTALRMAMQT REQHIRREKA NSNICTSQVL LANIASLYAV YHGPVGLKRI 370 380 390 400 410 420 ANRIHRLTDI LAAGLQQKGL KLRHAHYFDT LCVEVADKAA VLARAEAAEI NLRSDIHNAV 430 440 450 460 470 480 GITLDETTTR ENVAQLFNVL LGDSHGLNIE TLDKDVALDS RSIQQSMLRD DAILTHPVFN 490 500 510 520 530 540 RYHSETEMMR YMHSLERKDL ALNQAMIPLG SCTMKLNAAA EMIPITWPEF AELHPFCPPE 550 560 570 580 590 600 QAEGYHQMIS QLSDWLVKLT GYDAVCMQPN SGAQGEYAGL LAIRHYHESR NEGHRDICLI 610 620 630 640 650 660 PASAHGTNPA SAHMAGMQVV VVACDKNGNI DLDDLRAKAE QHAANLSCIM VTYPSTHGVY 670 680 690 700 710 720 EETIREVCEV VHQFGGQVYL DGANMNAQVG ITSPGFIGAD VSHLNLHKTF CIPHGGGGPG 730 740 750 760 770 780 MGPIGVKAHL APFVPGHSVV QIEGMLTRQG AVSAAPFGSA SILPISWMYI RMMGAEGLKQ 790 800 810 820 830 840 ASQVAILNAN YIASRLKDAY PVLYTGRDGR VAHECILDIR PLKEETGISE LDIAKRLIDY 850 860 870 880 890 900 GFHAPTMSFP VAGTLMVEPT ESEGKAELDR FIDAMLAIRA EIDQVKAGVW PLEDNPLVNA 910 920 930 940 950 PHIQSELVAE WAHPYSREVA VFPAGVADKY WPTVKRLDDV YGDRNLFCSC VPISDYQ

References

[1]

"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006468 Genomic DNA. Translation: AAL21928.1.
RefSeq	NP_461969.1. NC_003197.1.
3D structure databases
ProteinModelPortal	Q8ZM76.
ModBase	Search...
Protein-protein interaction databases
STRING	99287.STM3053.
Proteomic databases
PaxDb	Q8ZM76.
PRIDE	Q8ZM76.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL21928; AAL21928; STM3053.
GeneID	1254576.
KEGG	stm:STM3053.
PATRIC	32384851. VBISalEnt20916_3234.
Phylogenomic databases
eggNOG	COG1003.
HOGENOM	HOG000239369.
KO	K00281.
OMA	MNRSMIS.
ProtClustDB	PRK05367.
Family and domain databases
Gene3D	3.40.640.10. 2 hits.
HAMAP	MF_00711. GcvP.
InterPro	IPR020580. GDC-P_N. IPR020581. GDC_P. IPR003437. GDC_P_homo. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
PANTHER	PTHR11773. PTHR11773. 1 hit.
Pfam	PF02347. GDC-P. 2 hits. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 2 hits.
TIGRFAMs	TIGR00461. gcvP. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCSP_SALTY

Accession

Primary (citable) accession number: Q8ZM76

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2003
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 68 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program