Q8ZLV8 (Q8ZLV8_SALTY) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Tartronate semialdehyde reductase (TSAR) EMBL AAL22120.1
EC=1.1.1.60 EMBL AAL22120.1

Gene names

Name:	garR EMBL AAL22120.1
Ordered Locus Names:	STM3248

Organism

Salmonella typhimurium

Taxonomic identifier

90371 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Molecular function	Oxidoreductase EMBL AAL22120.1
Technical term	3D-structure PDB 1VPD Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glyoxylate metabolic process Inferred from electronic annotation. Source: InterPro pentose-phosphate shunt Inferred from electronic annotation. Source: InterPro valine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	2-hydroxy-3-oxopropionate reductase activity Inferred from electronic annotation. Source: EC 3-hydroxyisobutyrate dehydrogenase activity Inferred from electronic annotation. Source: InterPro coenzyme binding Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: InterPro phosphogluconate dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8ZLV8 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: A62B62F3B91F9DFC	FASTA	296	30,729
	10 20 30 40 50 60 MTMKVGFIGL GIMGKPMSKN LLKAGYSLVV SDRNPEAIAD VIAAGAETAS TAKAIAEQCD 70 80 90 100 110 120 VIITMLPNSP HVKEVALGEN GIIEGAKPGT VLIDMSSIAP LASREISDAL KAKGVEMLDA 130 140 150 160 170 180 PVSGGEPKAI DGTLSVMVGG DKAIFDKYYD LMKAMAGSVV HTGDIGAGNV TKLANQVIVA 190 200 210 220 230 240 LNIAAMSEAL TLATKAGVNP DLVYQAIRGG LAGSTVLDAK APMVMDRNFK PGFRIDLHIK 250 260 270 280 290 DLANALDTSH GVGAQLPLTA AVMEMMQALR ADGHGNDDHS ALACYYEKLA KVEVTR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.
[2]	"X-ray crystal structure of GarR-tartronate semialdehyde reductase from Salmonella typhimurium." Osipiuk J., Zhou M., Moy S., Collart F., Joachimiak A. J. Struct. Funct. Genomics 10:249-253(2009) [PubMed: 19184529] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE006468 Genomic DNA. Translation: AAL22120.1.

RefSeq

NP_462161.1. NC_003197.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1VPD	X-ray	1.65	A	1-296	[»]

ProteinModelPortal

Q8ZLV8.

SMR

Q8ZLV8. Positions 3-296.

ModBase

Search...

Proteomic databases

PRIDE

Q8ZLV8.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

1254771.

GenomeReviews

Gene locus STM3248 in contig AE006468_GR.

KEGG

stm:STM3248.

PATRIC

32385283. VBISalEnt20916_3447.

Phylogenomic databases

HOGENOM

HBG729179.

OMA

WSRRRES.

ProtClustDB

PRK11559.

Enzyme and pathway databases

BioCyc

STYP99287:STM3248-MONOMER.

Family and domain databases

InterPro

IPR002204. 3-OH-isobutyrate_DH-rel_CS.
IPR015815. 3hydroxyacid_DH/Rdtase.
IPR008927. 6-PGluconate_DH_C-like.
IPR006115. 6PGDH_NADP-bd.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
IPR006398. Tartro_sem_red.
[Graphical view]

Gene3D

G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.

KO

K00042.

PANTHER

PTHR22981. 3hydroxy_acid_DH. 1 hit.

Pfam

PF03446. NAD_binding_2. 1 hit.
[Graphical view]

SUPFAM

SSF48179. 6DGDH_C_like. 1 hit.

TIGRFAMs

TIGR01505. Tartro_sem_red. 1 hit.

PROSITE

PS00895. 3_HYDROXYISOBUT_DH. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q8ZLV8_SALTY

Accession

Primary (citable) accession number: Q8ZLV8

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2002
Last sequence update:	March 1, 2002
Last modified:	December 14, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)