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Q8ZLT0

- ASSY_SALTY

UniProt

Q8ZLT0 - ASSY_SALTY

Protein

Argininosuccinate synthase

Gene

argG

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431ATP; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei99 – 991CitrullineBy similarity
    Binding sitei129 – 1291ATP; via amide nitrogenBy similarity
    Binding sitei131 – 1311AspartateBy similarity
    Binding sitei131 – 1311ATPBy similarity
    Binding sitei135 – 1351AspartateBy similarity
    Binding sitei135 – 1351CitrullineBy similarity
    Binding sitei136 – 1361AspartateBy similarity
    Binding sitei136 – 1361ATPBy similarity
    Binding sitei139 – 1391CitrullineBy similarity
    Binding sitei192 – 1921CitrullineBy similarity
    Binding sitei194 – 1941ATPBy similarity
    Binding sitei201 – 2011CitrullineBy similarity
    Binding sitei203 – 2031CitrullineBy similarity
    Binding sitei280 – 2801CitrullineBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi17 – 259ATPBy similarity

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-3311-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthase (EC:6.3.4.5)
    Alternative name(s):
    Citrulline--aspartate ligase
    Gene namesi
    Name:argG
    Ordered Locus Names:STM3290
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 447446Argininosuccinate synthasePRO_0000148706Add
    BLAST

    Proteomic databases

    PaxDbiQ8ZLT0.
    PRIDEiQ8ZLT0.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8ZLT0.
    SMRiQ8ZLT0. Positions 2-445.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0137.
    KOiK01940.
    OMAiRQEMSEF.
    OrthoDBiEOG6K9QCV.
    PhylomeDBiQ8ZLT0.

    Family and domain databases

    Gene3Di1.10.287.400. 1 hit.
    3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00581. Arg_succ_synth_type2.
    InterProiIPR023437. Arg_succ_synth_type2_subfam.
    IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR024074. AS_cat/multimer_dom_body.
    IPR024073. AS_multimer_C_tail.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8ZLT0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTILKHLPA GQRIGIAFSG GLDTSAALLW MRQKGAVPYA YTANLGQPDE    50
    DDYDAIPRRA MEYGAENARL IDCRKQLVAE GIAAIQCGAF HNTTGGLTYF 100
    NTTPLGRAVT GTMLVAAMKE DGVNIWGDGS TYKGNDIERF YRYGLLTNAE 150
    LQIYKPWLDT DFIDELGGRH EMSEFMIACG FDYKMSVEKA YSTDSNMLGA 200
    THEAKDLEFL NSSVKIVNPI MGVKFWDESV KIPAEVVTVR FEQGHPVALN 250
    GKTFSDDVEM MLEANRIGGR HGLGMSDQIE NRIIEAKSRG IYEAPGMALL 300
    HIAYERLLTG IHNEDTIEQY HSHGRQLGKL LYQGRWFDSQ ALMLRDGLQR 350
    WVASQITGEV TLELRRGNDY SILNTVSDNL TYKAERLTME KGESVFSPDD 400
    RIGQLTMRNL DITDTREKLF GYAKAGLLTA SSATGLPQVE NLENKGK 447
    Length:447
    Mass (Da):49,754
    Last modified:January 23, 2007 - v3
    Checksum:i7E829BC54E5E9D71
    GO

    Sequence cautioni

    The sequence AAL22161.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL22161.1. Different initiation.
    RefSeqiNP_462202.2. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL22161; AAL22161; STM3290.
    GeneIDi1254813.
    KEGGistm:STM3290.S.
    PATRICi32385367. VBISalEnt20916_3488.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL22161.1 . Different initiation.
    RefSeqi NP_462202.2. NC_003197.1.

    3D structure databases

    ProteinModelPortali Q8ZLT0.
    SMRi Q8ZLT0. Positions 2-445.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q8ZLT0.
    PRIDEi Q8ZLT0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL22161 ; AAL22161 ; STM3290 .
    GeneIDi 1254813.
    KEGGi stm:STM3290.S.
    PATRICi 32385367. VBISalEnt20916_3488.

    Phylogenomic databases

    eggNOGi COG0137.
    KOi K01940.
    OMAi RQEMSEF.
    OrthoDBi EOG6K9QCV.
    PhylomeDBi Q8ZLT0.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci SENT99287:GCTI-3311-MONOMER.

    Family and domain databases

    Gene3Di 1.10.287.400. 1 hit.
    3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00581. Arg_succ_synth_type2.
    InterProi IPR023437. Arg_succ_synth_type2_subfam.
    IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR024074. AS_cat/multimer_dom_body.
    IPR024073. AS_multimer_C_tail.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.

    Entry informationi

    Entry nameiASSY_SALTY
    AccessioniPrimary (citable) accession number: Q8ZLT0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 95 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3