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Protein

Arabinose 5-phosphate isomerase KdsD

Gene

kdsD

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs). Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P) (By similarity).By similarity

Catalytic activityi

D-arabinose 5-phosphate = D-ribulose 5-phosphate.

Pathwayi: 3-deoxy-D-manno-octulosonate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Arabinose 5-phosphate isomerase KdsD (kdsD)
  2. 2-dehydro-3-deoxyphosphooctonate aldolase (kdsA)
  3. 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC (kdsC)
This subpathway is part of the pathway 3-deoxy-D-manno-octulosonate biosynthesis, which is itself part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate, the pathway 3-deoxy-D-manno-octulosonate biosynthesis and in Carbohydrate biosynthesis.

Pathwayi: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei59Catalytically relevantBy similarity1
Metal bindingi82ZincBy similarity1
Binding sitei82SubstrateBy similarity1
Binding sitei88SubstrateBy similarity1
Sitei111Catalytically relevantBy similarity1
Sitei152Catalytically relevantBy similarity1
Sitei193Catalytically relevantBy similarity1
Binding sitei275SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Lipopolysaccharide biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00030.
UPA00357; UER00473.

Names & Taxonomyi

Protein namesi
Recommended name:
Arabinose 5-phosphate isomerase KdsD (EC:5.3.1.13)
Short name:
API
Short name:
L-API
Gene namesi
Name:kdsD
Ordered Locus Names:STM3315
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3110.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001365791 – 328Arabinose 5-phosphate isomerase KdsDAdd BLAST328

Proteomic databases

PaxDbiQ8ZLS1.
PRIDEiQ8ZLS1.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi99287.STM3315.

Chemistry databases

BindingDBiQ8ZLS1.

Structurei

3D structure databases

ProteinModelPortaliQ8ZLS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 184SISPROSITE-ProRule annotationAdd BLAST144
Domaini210 – 268CBS 1PROSITE-ProRule annotationAdd BLAST59
Domaini277 – 328CBS 2PROSITE-ProRule annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni75 – 76Substrate bindingBy similarity2
Regioni114 – 123Substrate bindingBy similarity10
Regioni148 – 150Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the SIS family. GutQ/KpsF subfamily.Curated
Contains 2 CBS domains.PROSITE-ProRule annotation
Contains 1 SIS domain.PROSITE-ProRule annotation

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

eggNOGiENOG4105C2X. Bacteria.
COG0517. LUCA.
COG0794. LUCA.
HOGENOMiHOG000264729.
KOiK06041.
OMAiLMACLMR.
PhylomeDBiQ8ZLS1.

Family and domain databases

InterProiIPR000644. CBS_dom.
IPR004800. KdsD/KpsF-type.
IPR001347. SIS.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF01380. SIS. 1 hit.
[Graphical view]
PIRSFiPIRSF004692. KdsD_KpsF. 1 hit.
TIGRFAMsiTIGR00393. kpsF. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
PS51464. SIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZLS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHLALQPGF DFQQAGKEVL EIEREGLAEL DQYINQHFTL ACEKMFNCTG
60 70 80 90 100
KVVVMGMGKS GHIGRKMAAT FASTGTSSFF VHPGEAAHGD LGMVTPQDVV
110 120 130 140 150
IAISNSGESS EIAALIPVLK RLHVPLICIT GRPESSMARA ADVHLCVKVP
160 170 180 190 200
KEACPLGLAP TSSTTATLVM GDALAVALLK ARGFTAEDFA LSHPGGALGR
210 220 230 240 250
KLLLRVSDIM HTGDEIPHVN KHATLRDALL EITRKNLGMT VICDESMKID
260 270 280 290 300
GIFTDGDLRR VFDMGGDMRQ LGIAEVMTPG GIRVRPGILA VDALNLMQSR
310 320
HITSVLVADG DQLLGVLHMH DLLRAGVV
Length:328
Mass (Da):35,000
Last modified:March 1, 2002 - v1
Checksum:iCF9E3B2F86858F8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL22184.1.
RefSeqiNP_462225.1. NC_003197.1.
WP_000018617.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL22184; AAL22184; STM3315.
GeneIDi1254838.
KEGGistm:STM3315.
PATRICi32385425. VBISalEnt20916_3516.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL22184.1.
RefSeqiNP_462225.1. NC_003197.1.
WP_000018617.1. NC_003197.1.

3D structure databases

ProteinModelPortaliQ8ZLS1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM3315.

Chemistry databases

BindingDBiQ8ZLS1.
ChEMBLiCHEMBL3110.

Proteomic databases

PaxDbiQ8ZLS1.
PRIDEiQ8ZLS1.

Protocols and materials databases

DNASUi1254838.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL22184; AAL22184; STM3315.
GeneIDi1254838.
KEGGistm:STM3315.
PATRICi32385425. VBISalEnt20916_3516.

Phylogenomic databases

eggNOGiENOG4105C2X. Bacteria.
COG0517. LUCA.
COG0794. LUCA.
HOGENOMiHOG000264729.
KOiK06041.
OMAiLMACLMR.
PhylomeDBiQ8ZLS1.

Enzyme and pathway databases

UniPathwayiUPA00030.
UPA00357; UER00473.

Family and domain databases

InterProiIPR000644. CBS_dom.
IPR004800. KdsD/KpsF-type.
IPR001347. SIS.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF01380. SIS. 1 hit.
[Graphical view]
PIRSFiPIRSF004692. KdsD_KpsF. 1 hit.
TIGRFAMsiTIGR00393. kpsF. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
PS51464. SIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKDSD_SALTY
AccessioniPrimary (citable) accession number: Q8ZLS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.