Reviewed, UniProtKB/Swiss-Prot Q8ZLQ8 (NANK_SALTY)

Names and origin

Protein names

Recommended name:
    N-acetylmannosamine kinase
    EC=2.7.1.60
Alternative name(s):
    N-acetyl-D-mannosamine kinase
    ManNAc kinase

Gene names

Name:	nanK
Ordered Locus Names:	STM3336

Organism

Salmonella typhimurium [Complete proteome] [HAMAP]

Taxonomic identifier

90371 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P By similarity.
Catalytic activity	ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate. HAMAP MF_01234
Pathway	Amino-sugar metabolism; N-acetylneuraminic acid degradation; D-fructose 6-phosphate from N-acetylneuraminic acid: step 2/5. HAMAP MF_01234
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the ROK (nagC/xylR) family. NanK subfamily.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	N-acetylmannosamine metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP N-acylmannosamine kinase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 291	291	N-acetylmannosamine kinase HAMAP MF_01234		PRO_0000095702
Regions
	Nucleotide binding	5 – 12	8	ATP Potential
	Nucleotide binding	132 – 139	8	ATP Potential
Sites
	Metal binding	156	1	Zinc By similarity
	Metal binding	166	1	Zinc By similarity
	Metal binding	168	1	Zinc By similarity
	Metal binding	173	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8ZLQ8-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: DB0B005C29194A63	FASTA	291	30,078
	10 20 30 40 50 60 MTTLAIDIGG TKLAAALIDN NLRISQRREL PTPASKTPDA LREALKALVE PLRAEARQVA 70 80 90 100 110 120 IASTGIIQEG MLLALNPHNL GGLLHFPLVQ TLEAIAGLPT LAVNDAQAAA WAEYHALPDD 130 140 150 160 170 180 IRDMVFITVS TGVGGGVVCD GKLLTGKGGL AGHLGHTLAD PHGPVCGCGR VGCVEAIASG 190 200 210 220 230 240 RGMAAAARDD LAGCDAKTLF IRAGEGHQQA RHLVSQSAQV IARMIADVKA TTDCQCVVIG 250 260 270 280 290 GSVGLAEGYL EQVRAFLMQE PAPYHVALSA ARYRHDAGLL GAALLAQGDT L

References

[1]

"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE008853 Genomic DNA. Translation: AAL22205.1.
RefSeq	NP_462246.1.
3D structure databases
SMR	Q8ZLQ8. Positions 1-289.
ModBase	Search...
Genome annotation databases
GeneID	1254859.
GenomeReviews	Gene locus STM3336 in contig AE006468_GR.
KEGG	stm:STM3336.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8ZLQ8.
OMA	Q8ZLQ8. EYQALEG.
Enzyme and pathway databases
BioCyc	MetaCyc:MON-13105. STYP99287:STM3336-MON.
BRENDA	2.7.1.60. 2.
Family and domain databases
HAMAP	MF_01234. [Tree]
InterPro	IPR000600. ROK. [Graphical view]
Pfam	PF00480. ROK. 1 hit. [Graphical view]
PROSITE	PS01125. ROK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NANK_SALTY

Accession

Primary (citable) accession number: Q8ZLQ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 28, 2003
Last sequence update:	March 1, 2002
Last modified:	June 16, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)