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Protein

Phosphoglycolate phosphatase

Gene

gph

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.UniRule annotation

Catalytic activityi

2-phosphoglycolate + H2O = glycolate + phosphate.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation
  • chlorideUniRule annotation

Pathwayi: glycolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes glycolate from 2-phosphoglycolate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Phosphoglycolate phosphatase (gph)
This subpathway is part of the pathway glycolate biosynthesis, which is itself part of Organic acid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycolate from 2-phosphoglycolate, the pathway glycolate biosynthesis and in Organic acid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei13NucleophileUniRule annotation1
Metal bindingi13MagnesiumUniRule annotation1
Metal bindingi15MagnesiumUniRule annotation1
Metal bindingi192MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Chloride, Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00865; UER00834.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycolate phosphataseUniRule annotation (EC:3.1.3.18UniRule annotation)
Short name:
PGPUniRule annotation
Short name:
PGPaseUniRule annotation
Gene namesi
Name:gphUniRule annotation
Ordered Locus Names:STM3482
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001080411 – 252Phosphoglycolate phosphataseAdd BLAST252

Proteomic databases

PaxDbiQ8ZLK5.
PRIDEiQ8ZLK5.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi99287.STM3482.

Structurei

3D structure databases

ProteinModelPortaliQ8ZLK5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108VXP. Bacteria.
COG0546. LUCA.
HOGENOMiHOG000248344.
KOiK01091.
OMAiHPAPLFL.
PhylomeDBiQ8ZLK5.

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 1 hit.
HAMAPiMF_00495. GPH_hydrolase_bact. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR006346. PGP_bact.
IPR023198. PGP_dom2.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
PRINTSiPR00413. HADHALOGNASE.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01549. HAD-SF-IA-v1. 1 hit.
TIGR01509. HAD-SF-IA-v3. 1 hit.
TIGR01449. PGP_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZLK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKLQNIRGV AFDLDGTLVD SAPGLAAAVD MALYALELPV AGEERVITWI
60 70 80 90 100
GNGADVLMER ALTWAREERA TLRKTMGKPP VDEDIPAEEQ VRILRKLFDR
110 120 130 140 150
YYGEVAEEGT VLFPHVADTL GALHASGLSL GLVTNKPTPF VAPLLESLDI
160 170 180 190 200
AKYFSVVIGG DDVQNKKPHP EPLLLVASRL GMMPEQMLFV GDSRNDIQAA
210 220 230 240 250
KAAGCPSVGL TYGYNYGEAI ALSEPDVIYD SFNDLLPALG LPHSDNQEIK

ND
Length:252
Mass (Da):27,303
Last modified:March 1, 2002 - v1
Checksum:i1216F19E6D086B97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL22344.1.
RefSeqiNP_462385.1. NC_003197.1.
WP_000359655.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL22344; AAL22344; STM3482.
GeneIDi1255005.
KEGGistm:STM3482.
PATRICi32385765. VBISalEnt20916_3680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL22344.1.
RefSeqiNP_462385.1. NC_003197.1.
WP_000359655.1. NC_003197.1.

3D structure databases

ProteinModelPortaliQ8ZLK5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM3482.

Proteomic databases

PaxDbiQ8ZLK5.
PRIDEiQ8ZLK5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL22344; AAL22344; STM3482.
GeneIDi1255005.
KEGGistm:STM3482.
PATRICi32385765. VBISalEnt20916_3680.

Phylogenomic databases

eggNOGiENOG4108VXP. Bacteria.
COG0546. LUCA.
HOGENOMiHOG000248344.
KOiK01091.
OMAiHPAPLFL.
PhylomeDBiQ8ZLK5.

Enzyme and pathway databases

UniPathwayiUPA00865; UER00834.

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 1 hit.
HAMAPiMF_00495. GPH_hydrolase_bact. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR006346. PGP_bact.
IPR023198. PGP_dom2.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
PRINTSiPR00413. HADHALOGNASE.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01549. HAD-SF-IA-v1. 1 hit.
TIGR01509. HAD-SF-IA-v3. 1 hit.
TIGR01449. PGP_bact. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGPH_SALTY
AccessioniPrimary (citable) accession number: Q8ZLK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.