Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphoglycolate phosphatase

Gene

gph

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.UniRule annotation

Catalytic activityi

2-phosphoglycolate + H2O = glycolate + phosphate.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation
  • chlorideUniRule annotation

Pathwayi: glycolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes glycolate from 2-phosphoglycolate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Phosphoglycolate phosphatase (gph)
This subpathway is part of the pathway glycolate biosynthesis, which is itself part of Organic acid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycolate from 2-phosphoglycolate, the pathway glycolate biosynthesis and in Organic acid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei13NucleophileUniRule annotation1
Metal bindingi13MagnesiumUniRule annotation1
Metal bindingi15MagnesiumUniRule annotation1
Metal bindingi192MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism
LigandChloride, Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-3518-MONOMER
UniPathwayiUPA00865; UER00834

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycolate phosphataseUniRule annotation (EC:3.1.3.18UniRule annotation)
Short name:
PGPUniRule annotation
Short name:
PGPaseUniRule annotation
Gene namesi
Name:gphUniRule annotation
Ordered Locus Names:STM3482
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001080411 – 252Phosphoglycolate phosphataseAdd BLAST252

Proteomic databases

PaxDbiQ8ZLK5
PRIDEiQ8ZLK5

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi99287.STM3482

Structurei

3D structure databases

ProteinModelPortaliQ8ZLK5
SMRiQ8ZLK5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108VXP Bacteria
COG0546 LUCA
HOGENOMiHOG000248344
KOiK01091
OMAiYLCGKFG
PhylomeDBiQ8ZLK5

Family and domain databases

Gene3Di1.10.150.240, 1 hit
3.40.50.1000, 2 hits
HAMAPiMF_00495 GPH_hydrolase_bact, 1 hit
InterProiView protein in InterPro
IPR036412 HAD-like_sf
IPR006439 HAD-SF_hydro_IA
IPR023214 HAD_sf
IPR023198 PGP-like_dom2
IPR006346 PGPase/MupP
IPR037512 PGPase_prok
PRINTSiPR00413 HADHALOGNASE
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR01549 HAD-SF-IA-v1, 1 hit
TIGR01509 HAD-SF-IA-v3, 1 hit
TIGR01449 PGP_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZLK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKLQNIRGV AFDLDGTLVD SAPGLAAAVD MALYALELPV AGEERVITWI
60 70 80 90 100
GNGADVLMER ALTWAREERA TLRKTMGKPP VDEDIPAEEQ VRILRKLFDR
110 120 130 140 150
YYGEVAEEGT VLFPHVADTL GALHASGLSL GLVTNKPTPF VAPLLESLDI
160 170 180 190 200
AKYFSVVIGG DDVQNKKPHP EPLLLVASRL GMMPEQMLFV GDSRNDIQAA
210 220 230 240 250
KAAGCPSVGL TYGYNYGEAI ALSEPDVIYD SFNDLLPALG LPHSDNQEIK

ND
Length:252
Mass (Da):27,303
Last modified:March 1, 2002 - v1
Checksum:i1216F19E6D086B97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA Translation: AAL22344.1
RefSeqiNP_462385.1, NC_003197.2
WP_000359655.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL22344; AAL22344; STM3482
GeneIDi1255005
KEGGistm:STM3482
PATRICifig|99287.12.peg.3680

Similar proteinsi

Entry informationi

Entry nameiGPH_SALTY
AccessioniPrimary (citable) accession number: Q8ZLK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health