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Protein

RNA 3'-terminal phosphate cyclase

Gene

rtcA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.UniRule annotation

Catalytic activityi

ATP + (RNA)-3'-(3'-phospho-ribonucleoside) = AMP + diphosphate + (RNA)-3'-(2',3'-cyclophospho)-ribonucleoside.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei103ATPUniRule annotation1
Active sitei308Tele-AMP-histidine intermediateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi283 – 287ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-3554-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
RNA 3'-terminal phosphate cyclaseUniRule annotation (EC:6.5.1.4UniRule annotation)
Short name:
RNA cyclaseUniRule annotation
Short name:
RNA-3'-phosphate cyclaseUniRule annotation
Gene namesi
Name:rtcAUniRule annotation
Ordered Locus Names:STM3518
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001564211 – 339RNA 3'-terminal phosphate cyclaseAdd BLAST339

Proteomic databases

PaxDbiQ8ZLI0

Interactioni

Protein-protein interaction databases

STRINGi99287.STM3518

Structurei

3D structure databases

ProteinModelPortaliQ8ZLI0
SMRiQ8ZLI0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKX Bacteria
COG0430 LUCA
HOGENOMiHOG000015264
KOiK01974
OMAiANRPKPG
PhylomeDBiQ8ZLI0

Family and domain databases

Gene3Di3.30.360.20, 1 hit
3.65.10.20, 2 hits
HAMAPiMF_00200 RTC, 1 hit
InterProiView protein in InterPro
IPR013791 RNA3'-term_phos_cycl_insert
IPR023797 RNA3'_phos_cyclase_dom
IPR037136 RNA3'_phos_cyclase_dom_sf
IPR000228 RNA3'_term_phos_cyc
IPR017770 RNA3'_term_phos_cyc_type_1
IPR013792 RNA3'P_cycl/enolpyr_Trfase_a/b
IPR036553 RPTC_insert
PANTHERiPTHR11096 PTHR11096, 1 hit
PTHR11096:SF0 PTHR11096:SF0, 1 hit
PfamiView protein in Pfam
PF01137 RTC, 1 hit
PF05189 RTC_insert, 1 hit
PIRSFiPIRSF005378 RNA3'_term_phos_cycl_euk, 1 hit
SUPFAMiSSF52913 SSF52913, 1 hit
SSF55205 SSF55205, 2 hits
TIGRFAMsiTIGR03399 RNA_3prim_cycl, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZLI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARIIALDGA QGEGGGQILR SALSLSMITG QPFEMSGIRA GRAKPGLLRQ
60 70 80 90 100
HLTAVRAATE ICGAQVNGDE LGSQQLRFTP GPIRGGEYRF AIGSAGSCML
110 120 130 140 150
VLQTVLPALW FADGSSRVEV HGGTHNQAAP SADFICRVWE PLLARMGISQ
160 170 180 190 200
RTTLIKHGFY PAGGGAAATV VEPAASLRGL TLISRGETLR TTAEALLAAV
210 220 230 240 250
PYHVGEREVA TLEAHFPQAE KNVVALEGGC GPGNALSLMI QSEQLTELFA
260 270 280 290 300
AFGVKGTSAE AVANQVAHEA RRYLASPAAV GEHLADQLIL PLALAGEGAF
310 320 330
TVARASAHLL TNIAVVERFL PVRFSCEATE SGYLVRVSD
Length:339
Mass (Da):35,458
Last modified:March 1, 2002 - v1
Checksum:i182667CD81E31125
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA Translation: AAL22380.1
RefSeqiNP_462421.1, NC_003197.2
WP_000101027.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL22380; AAL22380; STM3518
GeneIDi1255041
KEGGistm:STM3518
PATRICifig|99287.12.peg.3718

Similar proteinsi

Entry informationi

Entry nameiRTCA_SALTY
AccessioniPrimary (citable) accession number: Q8ZLI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health