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Q8ZLB7

- GUN_SALTY

UniProt

Q8ZLB7 - GUN_SALTY

Protein

Endoglucanase

Gene

bcsZ

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Hydrolyzes carboxymethylcellulose.By similarity

    Catalytic activityi

    Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei56 – 561Proton donorBy similarity
    Active sitei117 – 1171NucleophilePROSITE-ProRule annotation

    GO - Molecular functioni

    1. cellulase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-3640-MONOMER.
    UniPathwayiUPA00694.

    Protein family/group databases

    CAZyiGH8. Glycoside Hydrolase Family 8.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endoglucanase (EC:3.2.1.4)
    Alternative name(s):
    Carboxymethylcellulase
    Short name:
    CMCase
    Cellulase
    Endo-1,4-beta-glucanase
    Gene namesi
    Name:bcsZ
    Synonyms:bcsC, celC
    Ordered Locus Names:STM3617
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 369347EndoglucanasePRO_0000007941Add
    BLAST

    Proteomic databases

    PaxDbiQ8ZLB7.
    PRIDEiQ8ZLB7.

    Interactioni

    Protein-protein interaction databases

    STRINGi99287.STM3617.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8ZLB7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3405.
    HOGENOMiHOG000259088.
    KOiK01179.
    OMAiDLWIAYT.
    OrthoDBiEOG6DG2PM.
    PhylomeDBiQ8ZLB7.

    Family and domain databases

    Gene3Di1.50.10.10. 1 hit.
    InterProiIPR008928. 6-hairpin_glycosidase-like.
    IPR012341. 6hp_glycosidase.
    IPR002037. Glyco_hydro_8.
    IPR019834. Glyco_hydro_8_CS.
    [Graphical view]
    PfamiPF01270. Glyco_hydro_8. 1 hit.
    [Graphical view]
    PRINTSiPR00735. GLHYDRLASE8.
    SUPFAMiSSF48208. SSF48208. 1 hit.
    PROSITEiPS00812. GLYCOSYL_HYDROL_F8. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8ZLB7-1 [UniParc]FASTAAdd to Basket

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    MMTMLRGWIT MLVMLTAINA QAACSWPAWE QFKKDYISQQ GRVIDPGDAR    50
    KITTSEGQSY AMFFALAAND RPAFAQLFNW TQNNLAQGSL REYLPAWLWG 100
    QKDPDTWSVL DSNSASDGDI WMAWSLLEAG RLWKETRYTE VGTALLKRIA 150
    REEVLNVPGL GSMLLPGKIG FAEANSWRFN PSYLPPQLAQ YFSRFGAPWS 200
    TLRETNLRLL LETAPKGFSP DWVRYESKQG WQLKAEKTLI SSYDAIRVYL 250
    WAGMMHDGDP QKARLLARFK PMATLTMKNG VPPEKVDVVS GNAQGTGPVG 300
    FSAALLPFLQ NRDAQAVQRQ RVADHFPGSD AYYNYVLTLF GQGWDQHRFR 350
    FTVKGELLPD WGQECVSSR 369
    Length:369
    Mass (Da):41,755
    Last modified:March 1, 2002 - v1
    Checksum:i6732DE30EA6332C6
    GO

    Sequence cautioni

    The sequence AAL69395.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAC44017.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti184 – 1841L → Q in AAL69395. 1 PublicationCurated
    Sequence conflicti366 – 3694VSSR → ANSH in AAL69395. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ315770 Genomic DNA. Translation: CAC44017.1. Different initiation.
    AF464897 Genomic DNA. Translation: AAL69395.1. Different initiation.
    AJ315148 Genomic DNA. Translation: CAC86197.1.
    AE006468 Genomic DNA. Translation: AAL22477.1.
    RefSeqiNP_462518.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL22477; AAL22477; STM3617.
    GeneIDi1255140.
    KEGGistm:STM3617.
    PATRICi32386051. VBISalEnt20916_3823.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ315770 Genomic DNA. Translation: CAC44017.1 . Different initiation.
    AF464897 Genomic DNA. Translation: AAL69395.1 . Different initiation.
    AJ315148 Genomic DNA. Translation: CAC86197.1 .
    AE006468 Genomic DNA. Translation: AAL22477.1 .
    RefSeqi NP_462518.1. NC_003197.1.

    3D structure databases

    ProteinModelPortali Q8ZLB7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM3617.

    Protein family/group databases

    CAZyi GH8. Glycoside Hydrolase Family 8.

    Proteomic databases

    PaxDbi Q8ZLB7.
    PRIDEi Q8ZLB7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL22477 ; AAL22477 ; STM3617 .
    GeneIDi 1255140.
    KEGGi stm:STM3617.
    PATRICi 32386051. VBISalEnt20916_3823.

    Phylogenomic databases

    eggNOGi COG3405.
    HOGENOMi HOG000259088.
    KOi K01179.
    OMAi DLWIAYT.
    OrthoDBi EOG6DG2PM.
    PhylomeDBi Q8ZLB7.

    Enzyme and pathway databases

    UniPathwayi UPA00694 .
    BioCyci SENT99287:GCTI-3640-MONOMER.

    Family and domain databases

    Gene3Di 1.50.10.10. 1 hit.
    InterProi IPR008928. 6-hairpin_glycosidase-like.
    IPR012341. 6hp_glycosidase.
    IPR002037. Glyco_hydro_8.
    IPR019834. Glyco_hydro_8_CS.
    [Graphical view ]
    Pfami PF01270. Glyco_hydro_8. 1 hit.
    [Graphical view ]
    PRINTSi PR00735. GLHYDRLASE8.
    SUPFAMi SSF48208. SSF48208. 1 hit.
    PROSITEi PS00812. GLYCOSYL_HYDROL_F8. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The multicellular morphotypes of Salmonella typhimurium and Escherichia coli produce cellulose as the second component of the extracellular matrix."
      Zogaj X., Nimtz M., Rohde M., Bokranz W., Roemling U.
      Mol. Microbiol. 39:1452-1463(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 14028 / SGSG 2980 / CDC 6516-60 / NCTC 12023.
    2. "Cloning and sequencing of CMCase gene from Salmonella typhimurium UR1."
      Yoo J.-S., Chung S.-Y., Choi Y.-L.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: UR1.
    3. "Genetic analysis of Salmonella enteritidis biofilm formation: critical role of cellulose."
      Solano C., Garcia B., Valle J., Berasain C., Ghigo J.-M., Gamazo C., Lasa I.
      Mol. Microbiol. 43:793-808(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: LT2.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.

    Entry informationi

    Entry nameiGUN_SALTY
    AccessioniPrimary (citable) accession number: Q8ZLB7
    Secondary accession number(s): Q8VQ10, Q93IN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 26, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3