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Q8ZLB7 (GUN_SALTY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endoglucanase

EC=3.2.1.4
Alternative name(s):
Carboxymethylcellulase
Short name=CMCase
Cellulase
Endo-1,4-beta-glucanase
Gene names
Name:bcsZ
Synonyms:bcsC, celC
Ordered Locus Names:STM3617
OrganismSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]
Taxonomic identifier99287 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolyzes carboxymethylcellulose By similarity.

Catalytic activity

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Pathway

Glycan metabolism; bacterial cellulose biosynthesis.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 8 (cellulase D) family.

Sequence caution

The sequence AAL69395.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAC44017.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Cellulose degradation
Polysaccharide degradation
   Cellular componentSecreted
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellulose catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncellulase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 369347Endoglucanase
PRO_0000007941

Sites

Active site561Proton donor By similarity
Active site1171Nucleophile Potential

Experimental info

Sequence conflict1841L → Q in AAL69395. Ref.2
Sequence conflict366 – 3694VSSR → ANSH in AAL69395. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8ZLB7 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 6732DE30EA6332C6

FASTA36941,755
        10         20         30         40         50         60 
MMTMLRGWIT MLVMLTAINA QAACSWPAWE QFKKDYISQQ GRVIDPGDAR KITTSEGQSY 

        70         80         90        100        110        120 
AMFFALAAND RPAFAQLFNW TQNNLAQGSL REYLPAWLWG QKDPDTWSVL DSNSASDGDI 

       130        140        150        160        170        180 
WMAWSLLEAG RLWKETRYTE VGTALLKRIA REEVLNVPGL GSMLLPGKIG FAEANSWRFN 

       190        200        210        220        230        240 
PSYLPPQLAQ YFSRFGAPWS TLRETNLRLL LETAPKGFSP DWVRYESKQG WQLKAEKTLI 

       250        260        270        280        290        300 
SSYDAIRVYL WAGMMHDGDP QKARLLARFK PMATLTMKNG VPPEKVDVVS GNAQGTGPVG 

       310        320        330        340        350        360 
FSAALLPFLQ NRDAQAVQRQ RVADHFPGSD AYYNYVLTLF GQGWDQHRFR FTVKGELLPD 


WGQECVSSR 

« Hide

References

« Hide 'large scale' references
[1]"The multicellular morphotypes of Salmonella typhimurium and Escherichia coli produce cellulose as the second component of the extracellular matrix."
Zogaj X., Nimtz M., Rohde M., Bokranz W., Roemling U.
Mol. Microbiol. 39:1452-1463(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 14028 / SGSG 2980 / CDC 6516-60 / NCTC 12023.
[2]"Cloning and sequencing of CMCase gene from Salmonella typhimurium UR1."
Yoo J.-S., Chung S.-Y., Choi Y.-L.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: UR1.
[3]"Genetic analysis of Salmonella enteritidis biofilm formation: critical role of cellulose."
Solano C., Garcia B., Valle J., Berasain C., Ghigo J.-M., Gamazo C., Lasa I.
Mol. Microbiol. 43:793-808(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: LT2.
[4]"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2."
McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. expand/collapse author list , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K.
Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ315770 Genomic DNA. Translation: CAC44017.1. Different initiation.
AF464897 Genomic DNA. Translation: AAL69395.1. Different initiation.
AJ315148 Genomic DNA. Translation: CAC86197.1.
AE006468 Genomic DNA. Translation: AAL22477.1.
RefSeqNP_462518.1. NC_003197.1.

3D structure databases

ProteinModelPortalQ8ZLB7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING99287.STM3617.

Protein family/group databases

CAZyGH8. Glycoside Hydrolase Family 8.

Proteomic databases

PaxDbQ8ZLB7.
PRIDEQ8ZLB7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL22477; AAL22477; STM3617.
GeneID1255140.
KEGGstm:STM3617.
PATRIC32386051. VBISalEnt20916_3823.

Phylogenomic databases

eggNOGCOG3405.
HOGENOMHOG000259088.
KOK01179.
OMADLWIAYT.
OrthoDBEOG6DG2PM.
PhylomeDBQ8ZLB7.

Enzyme and pathway databases

BioCycSENT99287:GCTI-3640-MONOMER.
UniPathwayUPA00694.

Family and domain databases

Gene3D1.50.10.10. 1 hit.
InterProIPR008928. 6-hairpin_glycosidase-like.
IPR012341. 6hp_glycosidase.
IPR002037. Glyco_hydro_8.
IPR019834. Glyco_hydro_8_CS.
[Graphical view]
PfamPF01270. Glyco_hydro_8. 1 hit.
[Graphical view]
PRINTSPR00735. GLHYDRLASE8.
SUPFAMSSF48208. SSF48208. 1 hit.
PROSITEPS00812. GLYCOSYL_HYDROL_F8. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGUN_SALTY
AccessionPrimary (citable) accession number: Q8ZLB7
Secondary accession number(s): Q8VQ10, Q93IN0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries