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Q8ZL83

- DLGD_SALTY

UniProt

Q8ZL83 - DLGD_SALTY

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Protein
2,3-diketo-L-gulonate reductase
Gene
dlgD, STM3668
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate By similarity.UniRule annotation

Catalytic activityi

3-dehydro-L-gulonate + NAD(P)+ = (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei44 – 441Proton donor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi168 – 1747NAD By similarity
Nucleotide bindingi224 – 2252NAD By similarity
Nucleotide bindingi304 – 3063NAD By similarity

GO - Molecular functioni

  1. 3-dehydro-L-gulonate 2-dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD+ binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSENT99287:GCTI-3693-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-diketo-L-gulonate reductase (EC:1.1.1.130)
Short name:
2,3-DKG reductase
Alternative name(s):
3-dehydro-L-gulonate 2-dehydrogenase
Gene namesi
Name:dlgD
Ordered Locus Names:STM3668
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3323322,3-diketo-L-gulonate reductaseUniRule annotation
PRO_0000083838Add
BLAST

Proteomic databases

PaxDbiQ8ZL83.
PRIDEiQ8ZL83.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi99287.STM3668.

Structurei

3D structure databases

ProteinModelPortaliQ8ZL83.
SMRiQ8ZL83. Positions 1-332.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2055.
HOGENOMiHOG000249660.
KOiK08092.
OMAiETCADIF.
OrthoDBiEOG6QK4PJ.
PhylomeDBiQ8ZL83.

Family and domain databases

HAMAPiMF_00820. Diketo_gul_reduc.
InterProiIPR023689. Diketo_gul_Rdtase.
IPR003767. Malate/L-lactate_DH.
[Graphical view]
PANTHERiPTHR11091. PTHR11091. 1 hit.
PfamiPF02615. Ldh_2. 1 hit.
[Graphical view]
SUPFAMiSSF89733. SSF89733. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZL83-1 [UniParc]FASTAAdd to Basket

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MKVTFEELKG AFYRVLRSRN IAEDTADECA EMFARTTESG VYSHGVNRFP    50
RFIQQLDNGD IIPDAKPQRV TSLGAIEQWD AQRAIGNLTA KKMMDRAIEL 100
ASDHGIGLVA LRNANHWMRG GSYGWQAAEK GYIGICWTNS IAVMPPWGAK 150
ECRIGTNPLI VAIPSTPITM VDMSMSMFSY GMLEVNRLAG RELPVDGGFD 200
DNGQLTKEPG VIEKNRRILP MGYWKGSGLS IVLDMIATLL SNGSSVAEVT 250
QENSDEYGVS QIFIAIEVDK LIDGATRDAK LQRIMDFITT AERADDNVAI 300
RLPGHEFTKL LDDNRRHGIT IDDSVWAKIQ AL 332
Length:332
Mass (Da):36,771
Last modified:March 1, 2002 - v1
Checksum:i44989A7C8613E7FD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL22527.1.
RefSeqiNP_462568.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL22527; AAL22527; STM3668.
GeneIDi1255192.
KEGGistm:STM3668.
PATRICi32386169. VBISalEnt20916_3881.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL22527.1 .
RefSeqi NP_462568.1. NC_003197.1.

3D structure databases

ProteinModelPortali Q8ZL83.
SMRi Q8ZL83. Positions 1-332.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM3668.

Proteomic databases

PaxDbi Q8ZL83.
PRIDEi Q8ZL83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL22527 ; AAL22527 ; STM3668 .
GeneIDi 1255192.
KEGGi stm:STM3668.
PATRICi 32386169. VBISalEnt20916_3881.

Phylogenomic databases

eggNOGi COG2055.
HOGENOMi HOG000249660.
KOi K08092.
OMAi ETCADIF.
OrthoDBi EOG6QK4PJ.
PhylomeDBi Q8ZL83.

Enzyme and pathway databases

BioCyci SENT99287:GCTI-3693-MONOMER.

Family and domain databases

HAMAPi MF_00820. Diketo_gul_reduc.
InterProi IPR023689. Diketo_gul_Rdtase.
IPR003767. Malate/L-lactate_DH.
[Graphical view ]
PANTHERi PTHR11091. PTHR11091. 1 hit.
Pfami PF02615. Ldh_2. 1 hit.
[Graphical view ]
SUPFAMi SSF89733. SSF89733. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiDLGD_SALTY
AccessioniPrimary (citable) accession number: Q8ZL83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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