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Protein

2,3-diketo-L-gulonate reductase

Gene

dlgD

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate.UniRule annotation

Catalytic activityi

3-dehydro-L-gulonate + NAD(P)+ = (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei44 – 441Proton donorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi168 – 1747NADUniRule annotation
Nucleotide bindingi224 – 2252NADUniRule annotation
Nucleotide bindingi304 – 3063NADUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSENT99287:GCTI-3693-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-diketo-L-gulonate reductaseUniRule annotation (EC:1.1.1.130UniRule annotation)
Short name:
2,3-DKG reductaseUniRule annotation
Alternative name(s):
3-dehydro-L-gulonate 2-dehydrogenaseUniRule annotation
Gene namesi
Name:dlgDUniRule annotation
Ordered Locus Names:STM3668
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3323322,3-diketo-L-gulonate reductasePRO_0000083838Add
BLAST

Proteomic databases

PaxDbiQ8ZL83.
PRIDEiQ8ZL83.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi99287.STM3668.

Structurei

3D structure databases

ProteinModelPortaliQ8ZL83.
SMRiQ8ZL83. Positions 1-332.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH2/MDH2 oxidoreductase family. DlgD subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG2055.
HOGENOMiHOG000249660.
KOiK08092.
OMAiYWKGSAL.
OrthoDBiEOG6QK4PJ.
PhylomeDBiQ8ZL83.

Family and domain databases

HAMAPiMF_00820. Diketo_gul_reduc.
InterProiIPR023689. Diketo_gul_Rdtase.
IPR003767. Malate/L-lactate_DH.
[Graphical view]
PANTHERiPTHR11091. PTHR11091. 1 hit.
PfamiPF02615. Ldh_2. 1 hit.
[Graphical view]
SUPFAMiSSF89733. SSF89733. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZL83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVTFEELKG AFYRVLRSRN IAEDTADECA EMFARTTESG VYSHGVNRFP
60 70 80 90 100
RFIQQLDNGD IIPDAKPQRV TSLGAIEQWD AQRAIGNLTA KKMMDRAIEL
110 120 130 140 150
ASDHGIGLVA LRNANHWMRG GSYGWQAAEK GYIGICWTNS IAVMPPWGAK
160 170 180 190 200
ECRIGTNPLI VAIPSTPITM VDMSMSMFSY GMLEVNRLAG RELPVDGGFD
210 220 230 240 250
DNGQLTKEPG VIEKNRRILP MGYWKGSGLS IVLDMIATLL SNGSSVAEVT
260 270 280 290 300
QENSDEYGVS QIFIAIEVDK LIDGATRDAK LQRIMDFITT AERADDNVAI
310 320 330
RLPGHEFTKL LDDNRRHGIT IDDSVWAKIQ AL
Length:332
Mass (Da):36,771
Last modified:March 1, 2002 - v1
Checksum:i44989A7C8613E7FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL22527.1.
RefSeqiNP_462568.1. NC_003197.1.
WP_000869012.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL22527; AAL22527; STM3668.
GeneIDi1255192.
KEGGistm:STM3668.
PATRICi32386169. VBISalEnt20916_3881.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL22527.1.
RefSeqiNP_462568.1. NC_003197.1.
WP_000869012.1. NC_003197.1.

3D structure databases

ProteinModelPortaliQ8ZL83.
SMRiQ8ZL83. Positions 1-332.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM3668.

Proteomic databases

PaxDbiQ8ZL83.
PRIDEiQ8ZL83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL22527; AAL22527; STM3668.
GeneIDi1255192.
KEGGistm:STM3668.
PATRICi32386169. VBISalEnt20916_3881.

Phylogenomic databases

eggNOGiCOG2055.
HOGENOMiHOG000249660.
KOiK08092.
OMAiYWKGSAL.
OrthoDBiEOG6QK4PJ.
PhylomeDBiQ8ZL83.

Enzyme and pathway databases

BioCyciSENT99287:GCTI-3693-MONOMER.

Family and domain databases

HAMAPiMF_00820. Diketo_gul_reduc.
InterProiIPR023689. Diketo_gul_Rdtase.
IPR003767. Malate/L-lactate_DH.
[Graphical view]
PANTHERiPTHR11091. PTHR11091. 1 hit.
PfamiPF02615. Ldh_2. 1 hit.
[Graphical view]
SUPFAMiSSF89733. SSF89733. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiDLGD_SALTY
AccessioniPrimary (citable) accession number: Q8ZL83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2002
Last modified: May 27, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.