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Q8ZL83

- DLGD_SALTY

UniProt

Q8ZL83 - DLGD_SALTY

Protein

2,3-diketo-L-gulonate reductase

Gene

dlgD

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate.UniRule annotation

    Catalytic activityi

    3-dehydro-L-gulonate + NAD(P)+ = (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei44 – 441Proton donorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi168 – 1747NADUniRule annotation
    Nucleotide bindingi224 – 2252NADUniRule annotation
    Nucleotide bindingi304 – 3063NADUniRule annotation

    GO - Molecular functioni

    1. 3-dehydro-L-gulonate 2-dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD+ binding Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-3693-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2,3-diketo-L-gulonate reductaseUniRule annotation (EC:1.1.1.130UniRule annotation)
    Short name:
    2,3-DKG reductaseUniRule annotation
    Alternative name(s):
    3-dehydro-L-gulonate 2-dehydrogenaseUniRule annotation
    Gene namesi
    Name:dlgDUniRule annotation
    Ordered Locus Names:STM3668
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3323322,3-diketo-L-gulonate reductasePRO_0000083838Add
    BLAST

    Proteomic databases

    PaxDbiQ8ZL83.
    PRIDEiQ8ZL83.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi99287.STM3668.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8ZL83.
    SMRiQ8ZL83. Positions 1-332.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH2/MDH2 oxidoreductase family. DlgD subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2055.
    HOGENOMiHOG000249660.
    KOiK08092.
    OMAiETCADIF.
    OrthoDBiEOG6QK4PJ.
    PhylomeDBiQ8ZL83.

    Family and domain databases

    HAMAPiMF_00820. Diketo_gul_reduc.
    InterProiIPR023689. Diketo_gul_Rdtase.
    IPR003767. Malate/L-lactate_DH.
    [Graphical view]
    PANTHERiPTHR11091. PTHR11091. 1 hit.
    PfamiPF02615. Ldh_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF89733. SSF89733. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8ZL83-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVTFEELKG AFYRVLRSRN IAEDTADECA EMFARTTESG VYSHGVNRFP    50
    RFIQQLDNGD IIPDAKPQRV TSLGAIEQWD AQRAIGNLTA KKMMDRAIEL 100
    ASDHGIGLVA LRNANHWMRG GSYGWQAAEK GYIGICWTNS IAVMPPWGAK 150
    ECRIGTNPLI VAIPSTPITM VDMSMSMFSY GMLEVNRLAG RELPVDGGFD 200
    DNGQLTKEPG VIEKNRRILP MGYWKGSGLS IVLDMIATLL SNGSSVAEVT 250
    QENSDEYGVS QIFIAIEVDK LIDGATRDAK LQRIMDFITT AERADDNVAI 300
    RLPGHEFTKL LDDNRRHGIT IDDSVWAKIQ AL 332
    Length:332
    Mass (Da):36,771
    Last modified:March 1, 2002 - v1
    Checksum:i44989A7C8613E7FD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL22527.1.
    RefSeqiNP_462568.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL22527; AAL22527; STM3668.
    GeneIDi1255192.
    KEGGistm:STM3668.
    PATRICi32386169. VBISalEnt20916_3881.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL22527.1 .
    RefSeqi NP_462568.1. NC_003197.1.

    3D structure databases

    ProteinModelPortali Q8ZL83.
    SMRi Q8ZL83. Positions 1-332.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM3668.

    Proteomic databases

    PaxDbi Q8ZL83.
    PRIDEi Q8ZL83.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL22527 ; AAL22527 ; STM3668 .
    GeneIDi 1255192.
    KEGGi stm:STM3668.
    PATRICi 32386169. VBISalEnt20916_3881.

    Phylogenomic databases

    eggNOGi COG2055.
    HOGENOMi HOG000249660.
    KOi K08092.
    OMAi ETCADIF.
    OrthoDBi EOG6QK4PJ.
    PhylomeDBi Q8ZL83.

    Enzyme and pathway databases

    BioCyci SENT99287:GCTI-3693-MONOMER.

    Family and domain databases

    HAMAPi MF_00820. Diketo_gul_reduc.
    InterProi IPR023689. Diketo_gul_Rdtase.
    IPR003767. Malate/L-lactate_DH.
    [Graphical view ]
    PANTHERi PTHR11091. PTHR11091. 1 hit.
    Pfami PF02615. Ldh_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF89733. SSF89733. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.

    Entry informationi

    Entry nameiDLGD_SALTY
    AccessioniPrimary (citable) accession number: Q8ZL83
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3