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Q8ZL83

- DLGD_SALTY

UniProt

Q8ZL83 - DLGD_SALTY

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Protein

2,3-diketo-L-gulonate reductase

Gene

dlgD

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate.UniRule annotation

Catalytic activityi

3-dehydro-L-gulonate + NAD(P)+ = (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei44 – 441Proton donorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi168 – 1747NADUniRule annotation
Nucleotide bindingi224 – 2252NADUniRule annotation
Nucleotide bindingi304 – 3063NADUniRule annotation

GO - Molecular functioni

  1. 3-dehydro-L-gulonate 2-dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD+ binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSENT99287:GCTI-3693-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-diketo-L-gulonate reductaseUniRule annotation (EC:1.1.1.130UniRule annotation)
Short name:
2,3-DKG reductaseUniRule annotation
Alternative name(s):
3-dehydro-L-gulonate 2-dehydrogenaseUniRule annotation
Gene namesi
Name:dlgDUniRule annotation
Ordered Locus Names:STM3668
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3323322,3-diketo-L-gulonate reductasePRO_0000083838Add
BLAST

Proteomic databases

PaxDbiQ8ZL83.
PRIDEiQ8ZL83.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi99287.STM3668.

Structurei

3D structure databases

ProteinModelPortaliQ8ZL83.
SMRiQ8ZL83. Positions 1-332.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH2/MDH2 oxidoreductase family. DlgD subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG2055.
HOGENOMiHOG000249660.
KOiK08092.
OMAiETCADIF.
OrthoDBiEOG6QK4PJ.
PhylomeDBiQ8ZL83.

Family and domain databases

HAMAPiMF_00820. Diketo_gul_reduc.
InterProiIPR023689. Diketo_gul_Rdtase.
IPR003767. Malate/L-lactate_DH.
[Graphical view]
PANTHERiPTHR11091. PTHR11091. 1 hit.
PfamiPF02615. Ldh_2. 1 hit.
[Graphical view]
SUPFAMiSSF89733. SSF89733. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZL83-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVTFEELKG AFYRVLRSRN IAEDTADECA EMFARTTESG VYSHGVNRFP
60 70 80 90 100
RFIQQLDNGD IIPDAKPQRV TSLGAIEQWD AQRAIGNLTA KKMMDRAIEL
110 120 130 140 150
ASDHGIGLVA LRNANHWMRG GSYGWQAAEK GYIGICWTNS IAVMPPWGAK
160 170 180 190 200
ECRIGTNPLI VAIPSTPITM VDMSMSMFSY GMLEVNRLAG RELPVDGGFD
210 220 230 240 250
DNGQLTKEPG VIEKNRRILP MGYWKGSGLS IVLDMIATLL SNGSSVAEVT
260 270 280 290 300
QENSDEYGVS QIFIAIEVDK LIDGATRDAK LQRIMDFITT AERADDNVAI
310 320 330
RLPGHEFTKL LDDNRRHGIT IDDSVWAKIQ AL
Length:332
Mass (Da):36,771
Last modified:March 1, 2002 - v1
Checksum:i44989A7C8613E7FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL22527.1.
RefSeqiNP_462568.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL22527; AAL22527; STM3668.
GeneIDi1255192.
KEGGistm:STM3668.
PATRICi32386169. VBISalEnt20916_3881.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL22527.1 .
RefSeqi NP_462568.1. NC_003197.1.

3D structure databases

ProteinModelPortali Q8ZL83.
SMRi Q8ZL83. Positions 1-332.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM3668.

Proteomic databases

PaxDbi Q8ZL83.
PRIDEi Q8ZL83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL22527 ; AAL22527 ; STM3668 .
GeneIDi 1255192.
KEGGi stm:STM3668.
PATRICi 32386169. VBISalEnt20916_3881.

Phylogenomic databases

eggNOGi COG2055.
HOGENOMi HOG000249660.
KOi K08092.
OMAi ETCADIF.
OrthoDBi EOG6QK4PJ.
PhylomeDBi Q8ZL83.

Enzyme and pathway databases

BioCyci SENT99287:GCTI-3693-MONOMER.

Family and domain databases

HAMAPi MF_00820. Diketo_gul_reduc.
InterProi IPR023689. Diketo_gul_Rdtase.
IPR003767. Malate/L-lactate_DH.
[Graphical view ]
PANTHERi PTHR11091. PTHR11091. 1 hit.
Pfami PF02615. Ldh_2. 1 hit.
[Graphical view ]
SUPFAMi SSF89733. SSF89733. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiDLGD_SALTY
AccessioniPrimary (citable) accession number: Q8ZL83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3