Reviewed, UniProtKB/Swiss-Prot Q8ZL67 (MTLD_SALTY)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	STM3686

Organism

Salmonella typhimurium [Complete proteome] [HAMAP]

Taxonomic identifier

602 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD(+) = D-fructose 6-phosphate + NADH.
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 382	382	Mannitol-1-phosphate 5-dehydrogenase		PRO_0000170717
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8ZL67-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: C5781FBF88C507E1	FASTA	382	40,900
	10 20 30 40 50 60 MKALHFGAGN IGRGFIGKLL ADAGIQLTFA DVNQVVLDAL NARHSYQVHV VGENEQVDTV 70 80 90 100 110 120 SGVNAVSSIG DDVVDLIAHV DLITTAVGPV VLERIAPAIA KGLVKRKAQG VDAPLNIIAC 130 140 150 160 170 180 ENMVRGTTQL KGHVMNALAD GDKAWVEQHV GFVDSAVDRI VPPSASATND PLEVTVETFS 190 200 210 220 230 240 EWIVDKTQFK GALPNIPGME LTDNLMAFVE RKLFTLNTGH AITAYLGKLA GHQTIRDAIL 250 260 270 280 290 300 DESIRAVVKG AMEESGAVLI KRYGFDADKH AAYIQKILGR FENPYLKDDV ERVGRQPLRK 310 320 330 340 350 360 LSAGDRLIKP LLGTLEYGLP HVNLVKGIAA AMHFRSDEDP QAQELAALIT EKGPQAALAQ 370 380 ISGLDANSDV VAEAVNAYNA TK

References

[1]

"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE008871 Genomic DNA. Translation: AAL22545.1.
RefSeq	NP_462586.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1255210.
GenomeReviews	Gene locus STM3686 in contig AE006468_GR.
KEGG	stm:STM3686.
NMPDR	fig|99287.1.peg.3562.
Organism-specific databases
StyGene	mtlD. SG?????.
CMR	Search...
Phylogenomic databases
HOGENOM	Q8ZL67.
Enzyme and pathway databases
BioCyc	STYP99287:STM3686-MON.
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DHase_multihelical. IPR013118. Mannitol_DHase_C. IPR000669. Mannitol_DHase_core. IPR013131. Mannitol_DHase_N. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_SALTY

Accession

Primary (citable) accession number: Q8ZL67

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	March 1, 2002
Last modified:	November 25, 2008
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)