Reviewed,
UniProtKB/Swiss-Prot Q8ZL61 (LLDD_SALTY)
Last modified
November 25, 2008.
Version 38.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: L-lactate dehydrogenase [cytochrome] EC=1.1.2.3 | ||||
| Gene names |
| ||||
| Organism | Salmonella typhimurium [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 602 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella |
Protein attributes
| Sequence length | 396 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H(+). |
| Cofactor | FMN By similarity. |
| Sequence similarities | Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. Contains 1 FMN hydroxy acid dehydrogenase domain. |
Ontologies
Keywords | |
|---|---|
| Ligand | FMN Flavoprotein |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | FMN binding Inferred from electronic annotation. Source: InterPro L-lactate dehydrogenase (cytochrome) activityInferred from electronic annotation. Source: HAMAP electron carrier activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 396 | 396 | L-lactate dehydrogenase [cytochrome] | PRO_0000206347 | |||||
Regions | |||||||||
| Domain | 1 – 380 | 380 | FMN hydroxy acid dehydrogenase | ||||||
| Nucleotide binding | 306 – 330 | 25 | FMN By similarity | ||||||
Sites | |||||||||
| Active site | 275 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 24 | 1 | Substrate Potential | ||||||
| Binding site | 106 | 1 | FMN By similarity | ||||||
| Binding site | 127 | 1 | FMN By similarity | ||||||
| Binding site | 129 | 1 | Substrate By similarity | ||||||
| Binding site | 155 | 1 | FMN By similarity | ||||||
| Binding site | 164 | 1 | Substrate By similarity | ||||||
| Binding site | 251 | 1 | FMN By similarity | ||||||
| Binding site | 278 | 1 | Substrate Potential | ||||||
Sequences
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References
| [1] | "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. Wilson R.K.Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720. |
Cross-references
Sequence databases | |
|---|---|
| AE008871 Genomic DNA. Translation: AAL22553.1. | |
| RefSeq | NP_462594.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1GOX based on UniProtKB P05414. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1255218. |
| GenomeReviews | Gene locus STM3694 in contig AE006468_GR. |
| KEGG | stm:STM3694. |
| NMPDR | fig|99287.1.peg.3570. |
Organism-specific databases | |
| StyGene | lldD. SG?????. |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q8ZL61. |
Enzyme and pathway databases | |
| BioCyc | STYP99287:STM3694-MON. |
Family and domain databases | |
| HAMAP | MF_01559. [Tree] |
| InterPro | IPR013785. Aldolase_TIM. IPR012133. Alpha_OHA_DHase_FMN. IPR008259. FMN_hydac_DHase_AS. IPR000262. FMN_OHA_DHase. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| Pfam | PF01070. FMN_dh. 1 hit. [Graphical view] |
| PIRSF | PIRSF000138. Al-hdrx_acd_dh. 1 hit. |
| PROSITE | PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit. PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | LLDD_SALTY | ||||||||
| Accession | Primary (citable) accession number: Q8ZL61 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Salmonella typhimurium Salmonella typhimurium (strain LT2): entries, gene names and cross-references to StyGene |
| SIMILARITY comments Index of protein domains and families |

Clusters with


