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Q8ZKW6

- MNMG_SALTY

UniProt

Q8ZKW6 - MNMG_SALTY

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Protein
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG
Gene
mnmG, gidA, STM3874
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm5s2U34 By similarity.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei125 – 1251FAD; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei180 – 1801FAD By similarity
Binding sitei370 – 3701FAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 186FAD By similarity
Nucleotide bindingi273 – 28715NAD Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. tRNA wobble uridine modification Source: InterPro
Complete GO annotation...

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciSENT99287:GCTI-3904-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG
Alternative name(s):
Glucose-inhibited division protein A
Gene namesi
Name:mnmG
Synonyms:gidA
Ordered Locus Names:STM3874
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 629629tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmGUniRule annotation
PRO_0000117171Add
BLAST

Proteomic databases

PaxDbiQ8ZKW6.
PRIDEiQ8ZKW6.

Interactioni

Subunit structurei

Homodimer By similarity. Heterotetramer of two MnmE and two MnmG subunits By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi99287.STM3874.

Structurei

3D structure databases

ProteinModelPortaliQ8ZKW6.
SMRiQ8ZKW6. Positions 1-553.

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family.

Phylogenomic databases

eggNOGiCOG0445.
HOGENOMiHOG000201059.
KOiK03495.
OMAiHTNEQTH.
OrthoDBiEOG6W9X6J.
PhylomeDBiQ8ZKW6.

Family and domain databases

HAMAPiMF_00129. MnmG_GidA.
InterProiIPR004416. GidA.
IPR026904. GidA-assoc_3.
IPR002218. GIDA-rel.
IPR020595. GIDA-rel_CS.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
PF13932. GIDA_assoc_3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00136. gidA. 1 hit.
PROSITEiPS01280. GIDA_1. 1 hit.
PS01281. GIDA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZKW6-1 [UniParc]FASTAAdd to Basket

« Hide

MFYQDPFDVI IIGGGHAGTE AAMAAARMGQ QTLLLTHNID TLGQMSCNPA    50
IGGIGKGHLV KEVDALGGLM AKAIDQAGIQ FRILNASKGP AVRATRAQAD 100
RVLYRQAVRT ALENQPNLMI FQQAVEDLIV ENDRVVGAVT QMGLKFRAKA 150
VVLTVGTFLD GKIHIGLDNY SGGRAGDPPS IPLSRRLREL PLRVSRLKTG 200
TPPRIDARTI DFSVLAQQHG DNPMPVFSFM GNASQHPQQV PCYITHTNEK 250
THDVIRNNLD RSPMYAGVIE GIGPRYCPSI EDKVMRFADR NQHQIFLEPE 300
GLTSNEIYPN GISTSLPFDV QMQIVRSMQG MENAKIVRPG YAIEYDFFDP 350
RDLKPTLESK FIHGLFFAGQ INGTTGYEEA AAQGLLAGLN AARLSADKEG 400
WAPARSQAYL GVLVDDLCTL GTKEPYRMFT SRAEYRLMLR EDNADLRLTE 450
MGRELGLVDD ERWARFNEKL ENIERERQRL KSTWVTPSAE SADEVNAHLT 500
TPLSREASGE DLLRRPEMTY AQLTSLAAFA PALEDEQAAE QVEIQVKYEG 550
YIARQQDEIE KQLRNENTLL PATLDYRQVS GLSNEVIAKL NDHKPASIGQ 600
ASRISGVTPA AISILLVWLK KQGMLRRSA 629
Length:629
Mass (Da):69,640
Last modified:March 1, 2002 - v1
Checksum:i9B1693233DB1FDA6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL22732.1.
RefSeqiNP_462773.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL22732; AAL22732; STM3874.
GeneIDi1255401.
KEGGistm:STM3874.
PATRICi32386617. VBISalEnt20916_4104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL22732.1 .
RefSeqi NP_462773.1. NC_003197.1.

3D structure databases

ProteinModelPortali Q8ZKW6.
SMRi Q8ZKW6. Positions 1-553.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM3874.

Proteomic databases

PaxDbi Q8ZKW6.
PRIDEi Q8ZKW6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL22732 ; AAL22732 ; STM3874 .
GeneIDi 1255401.
KEGGi stm:STM3874.
PATRICi 32386617. VBISalEnt20916_4104.

Phylogenomic databases

eggNOGi COG0445.
HOGENOMi HOG000201059.
KOi K03495.
OMAi HTNEQTH.
OrthoDBi EOG6W9X6J.
PhylomeDBi Q8ZKW6.

Enzyme and pathway databases

BioCyci SENT99287:GCTI-3904-MONOMER.

Family and domain databases

HAMAPi MF_00129. MnmG_GidA.
InterProi IPR004416. GidA.
IPR026904. GidA-assoc_3.
IPR002218. GIDA-rel.
IPR020595. GIDA-rel_CS.
[Graphical view ]
Pfami PF01134. GIDA. 1 hit.
PF13932. GIDA_assoc_3. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00136. gidA. 1 hit.
PROSITEi PS01280. GIDA_1. 1 hit.
PS01281. GIDA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiMNMG_SALTY
AccessioniPrimary (citable) accession number: Q8ZKW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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