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Q8ZKR2

- Q8ZKR2_SALTY

UniProt

Q8ZKR2 - Q8ZKR2_SALTY

Protein
Submitted name:

Putative sugar kinase

Gene

STM4066

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei187 – 1871ATPanalogImported
    Binding sitei192 – 1921ATPanalogImported
    Sitei249 – 2491Transition state stabilizer; via amide nitrogenImported
    Sitei250 – 2501Transition state stabilizer; via amide nitrogenImported
    Binding sitei251 – 2511ATPanalog; via amide nitrogenImported
    Sitei251 – 2511Transition state stabilizer; via amide nitrogenImported
    Active sitei252 – 2521Proton donor/acceptorImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi158 – 1603ATPanalogImported
    Nucleotide bindingi220 – 2256ATPanalogImported
    Nucleotide bindingi281 – 2844ATPanalogImported

    GO - Molecular functioni

    1. CDP-diacylglycerol diphosphatase activity Source: UniProtKB-EC
    2. fructokinase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW
    4. ribokinase activity Source: InterPro

    GO - Biological processi

    1. D-ribose metabolic process Source: InterPro

    Keywords - Molecular functioni

    HydrolaseImported, KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Ligandi

    Nucleotide-bindingImported

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-4096-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative sugar kinaseImported (EC:2.7.1.4Imported, EC:3.6.1.26Imported)
    Gene namesi
    Ordered Locus Names:STM4066Imported
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)Imported
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi99287.STM4066.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1TYYX-ray2.60A/B1-319[»]
    1TZ3X-ray2.90A/B1-319[»]
    1TZ6X-ray2.70A/B1-319[»]
    ProteinModelPortaliQ8ZKR2.
    SMRiQ8ZKR2. Positions 5-310.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8ZKR2.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the carbohydrate kinase PfkB family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000235951.
    KOiK00847.
    OMAiICGALAT.
    OrthoDBiEOG6716JN.
    PhylomeDBiQ8ZKR2.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    InterProiIPR002173. Carboh/pur_kinase_PfkB_CS.
    IPR011611. PfkB_dom.
    IPR002139. Ribokinase.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF00294. PfkB. 1 hit.
    [Graphical view]
    PRINTSiPR00990. RIBOKINASE.
    SUPFAMiSSF53613. SSF53613. 1 hit.
    PROSITEiPS00584. PFKB_KINASES_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8ZKR2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKAMNKVWVI GDASVDLVPE KQNSYLKCPG GASANVGVCV ARLGGECGFI    50
    GCLGDDDAGR FLRQVFQDNG VDVTFLRLDA DLTSAVLIVN LTADGERSFT 100
    YLVHPGADTY VSPQDLPPFR QYEWFYFSSI GLTDRPAREA CLEGARRMRE 150
    AGGYVLFDVN LRSKMWGNTD EIPELIARSA ALASICKVSA DELCQLSGAS 200
    HWQDARYYLR DLGCDTTIIS LGADGALLIT AEGEFHFPAP RVDVVDTTGA 250
    GDAFVGGLLF TLSRANCWDH ALLAEAISNA NACGAMAVTA KGAMTALPFP 300
    DQLNTFLSSH SLAQAMTVK 319
    Length:319
    Mass (Da):34,238
    Last modified:March 1, 2002 - v1
    Checksum:iA899A6735BC25D66
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL22906.1.
    RefSeqiNP_462947.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL22906; AAL22906; STM4066.
    GeneIDi1255593.
    KEGGistm:STM4066.
    PATRICi32387012. VBISalEnt20916_4286.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL22906.1 .
    RefSeqi NP_462947.1. NC_003197.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1TYY X-ray 2.60 A/B 1-319 [» ]
    1TZ3 X-ray 2.90 A/B 1-319 [» ]
    1TZ6 X-ray 2.70 A/B 1-319 [» ]
    ProteinModelPortali Q8ZKR2.
    SMRi Q8ZKR2. Positions 5-310.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM4066.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL22906 ; AAL22906 ; STM4066 .
    GeneIDi 1255593.
    KEGGi stm:STM4066.
    PATRICi 32387012. VBISalEnt20916_4286.

    Phylogenomic databases

    HOGENOMi HOG000235951.
    KOi K00847.
    OMAi ICGALAT.
    OrthoDBi EOG6716JN.
    PhylomeDBi Q8ZKR2.

    Enzyme and pathway databases

    BioCyci SENT99287:GCTI-4096-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q8ZKR2.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    InterProi IPR002173. Carboh/pur_kinase_PfkB_CS.
    IPR011611. PfkB_dom.
    IPR002139. Ribokinase.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF00294. PfkB. 1 hit.
    [Graphical view ]
    PRINTSi PR00990. RIBOKINASE.
    SUPFAMi SSF53613. SSF53613. 1 hit.
    PROSITEi PS00584. PFKB_KINASES_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720Imported.
    2. "Crystal structure of an aminoimidazole riboside kinase from Salmonella enterica: implications for the evolution of the ribokinase superfamily."
      Zhang Y., Dougherty M., Downs D.M., Ealick S.E.
      Structure 12:1809-1821(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) IN COMPLEX WITH ATPANALOG, ACTIVE SITE.

    Entry informationi

    Entry nameiQ8ZKR2_SALTY
    AccessioniPrimary (citable) accession number: Q8ZKR2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3