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Protein
Submitted name:

Putative sugar kinase

Gene

STM4066

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei187 – 1871ATP analogCombined sources
Binding sitei192 – 1921ATP analogCombined sources
Sitei249 – 2491Transition state stabilizer; via amide nitrogenCombined sources
Sitei250 – 2501Transition state stabilizer; via amide nitrogenCombined sources
Binding sitei251 – 2511ATP analog; via amide nitrogenCombined sources
Sitei251 – 2511Transition state stabilizer; via amide nitrogenCombined sources
Active sitei252 – 2521Proton donor/acceptorCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi158 – 1603ATP analogCombined sources
Nucleotide bindingi220 – 2256ATP analogCombined sources
Nucleotide bindingi281 – 2844ATP analogCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseImported, KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

Nucleotide-bindingCombined sources

Enzyme and pathway databases

BioCyciSENT99287:GCTI-4096-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Putative sugar kinaseImported (EC:2.7.1.4Imported, EC:3.6.1.26Imported)
Gene namesi
Ordered Locus Names:STM4066Imported
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)Imported
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi99287.STM4066.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TYYX-ray2.60A/B1-319[»]
1TZ3X-ray2.90A/B1-319[»]
1TZ6X-ray2.70A/B1-319[»]
ProteinModelPortaliQ8ZKR2.
SMRiQ8ZKR2. Positions 5-310.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8ZKR2.

Family & Domainsi

Sequence similaritiesi

Belongs to the carbohydrate kinase PfkB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000235951.
KOiK00847.
OMAiCLGENEG.
OrthoDBiEOG6716JN.
PhylomeDBiQ8ZKR2.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR002173. Carboh/pur_kinase_PfkB_CS.
IPR011611. PfkB_dom.
IPR002139. Ribokinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF00294. PfkB. 1 hit.
[Graphical view]
PRINTSiPR00990. RIBOKINASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
PROSITEiPS00584. PFKB_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZKR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAMNKVWVI GDASVDLVPE KQNSYLKCPG GASANVGVCV ARLGGECGFI
60 70 80 90 100
GCLGDDDAGR FLRQVFQDNG VDVTFLRLDA DLTSAVLIVN LTADGERSFT
110 120 130 140 150
YLVHPGADTY VSPQDLPPFR QYEWFYFSSI GLTDRPAREA CLEGARRMRE
160 170 180 190 200
AGGYVLFDVN LRSKMWGNTD EIPELIARSA ALASICKVSA DELCQLSGAS
210 220 230 240 250
HWQDARYYLR DLGCDTTIIS LGADGALLIT AEGEFHFPAP RVDVVDTTGA
260 270 280 290 300
GDAFVGGLLF TLSRANCWDH ALLAEAISNA NACGAMAVTA KGAMTALPFP
310
DQLNTFLSSH SLAQAMTVK
Length:319
Mass (Da):34,238
Last modified:March 1, 2002 - v1
Checksum:iA899A6735BC25D66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL22906.1.
RefSeqiNP_462947.1. NC_003197.1.
WP_000646499.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL22906; AAL22906; STM4066.
GeneIDi1255593.
KEGGistm:STM4066.
PATRICi32387012. VBISalEnt20916_4286.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL22906.1.
RefSeqiNP_462947.1. NC_003197.1.
WP_000646499.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TYYX-ray2.60A/B1-319[»]
1TZ3X-ray2.90A/B1-319[»]
1TZ6X-ray2.70A/B1-319[»]
ProteinModelPortaliQ8ZKR2.
SMRiQ8ZKR2. Positions 5-310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM4066.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL22906; AAL22906; STM4066.
GeneIDi1255593.
KEGGistm:STM4066.
PATRICi32387012. VBISalEnt20916_4286.

Phylogenomic databases

HOGENOMiHOG000235951.
KOiK00847.
OMAiCLGENEG.
OrthoDBiEOG6716JN.
PhylomeDBiQ8ZKR2.

Enzyme and pathway databases

BioCyciSENT99287:GCTI-4096-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ8ZKR2.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR002173. Carboh/pur_kinase_PfkB_CS.
IPR011611. PfkB_dom.
IPR002139. Ribokinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF00294. PfkB. 1 hit.
[Graphical view]
PRINTSiPR00990. RIBOKINASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
PROSITEiPS00584. PFKB_KINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720Imported.
  2. "Crystal structure of an aminoimidazole riboside kinase from Salmonella enterica: implications for the evolution of the ribokinase superfamily."
    Zhang Y., Dougherty M., Downs D.M., Ealick S.E.
    Structure 12:1809-1821(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) IN COMPLEX WITH ATP ANALOG, ACTIVE SITE.

Entry informationi

Entry nameiQ8ZKR2_SALTY
AccessioniPrimary (citable) accession number: Q8ZKR2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: July 22, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.