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Protein

Acetylornithine deacetylase

Gene

argE

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Displays a broad specificity and can also deacylate substrates such as acetylarginine, acetylhistidine or acetylglutamate semialdehyde.By similarity

Catalytic activityi

N2-acetyl-L-ornithine + H2O = acetate + L-ornithine.

Cofactori

Protein has several cofactor binding sites:
  • Zn2+By similarity, Co2+By similarityNote: Binds 2 Zn2+ or Co2+ ions per subunit.By similarity
  • glutathioneBy similarity

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-ornithine from N(2)-acetyl-L-ornithine (linear).
Proteins known to be involved in this subpathway in this organism are:
  1. Acetylornithine deacetylase (argE)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine from N(2)-acetyl-L-ornithine (linear), the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi80Cobalt or zinc 1By similarity1
Active sitei82By similarity1
Metal bindingi112Cobalt or zinc 1By similarity1
Metal bindingi112Cobalt or zinc 2By similarity1
Active sitei144Proton acceptorBy similarity1
Metal bindingi145Cobalt or zinc 2By similarity1
Metal bindingi169Cobalt or zinc 1By similarity1
Metal bindingi355Cobalt or zinc 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandCobalt, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-4161-MONOMER
UniPathwayiUPA00068; UER00110

Protein family/group databases

MEROPSiM20.974

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine deacetylase (EC:3.5.1.16)
Short name:
AO
Short name:
Acetylornithinase
Alternative name(s):
N-acetylornithinase
Short name:
NAO
Gene namesi
Name:argE
Ordered Locus Names:STM4120
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001852491 – 383Acetylornithine deacetylaseAdd BLAST383

Proteomic databases

PaxDbiQ8ZKL9
PRIDEiQ8ZKL9

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi99287.STM4120

Structurei

3D structure databases

ProteinModelPortaliQ8ZKL9
SMRiQ8ZKL9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20A family. ArgE subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105CWC Bacteria
COG0624 LUCA
HOGENOMiHOG000243769
KOiK01438
OMAiCAHQPGE
PhylomeDBiQ8ZKL9

Family and domain databases

CDDicd03894 M20_ArgE, 1 hit
HAMAPiMF_01108 ArgE, 1 hit
InterProiView protein in InterPro
IPR010169 AcOrn-deacetyl
IPR001261 ArgE/DapE_CS
IPR036264 Bact_exopeptidase_dim_dom
IPR002933 Peptidase_M20
IPR011650 Peptidase_M20_dimer
PANTHERiPTHR43808:SF1 PTHR43808:SF1, 1 hit
PfamiView protein in Pfam
PF07687 M20_dimer, 1 hit
PF01546 Peptidase_M20, 1 hit
SUPFAMiSSF55031 SSF55031, 1 hit
TIGRFAMsiTIGR01892 AcOrn-deacetyl, 1 hit
PROSITEiView protein in PROSITE
PS00758 ARGE_DAPE_CPG2_1, 1 hit
PS00759 ARGE_DAPE_CPG2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ZKL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNVLPPFIE IYRALIATPS ISATEESLDQ SNASLITLLA GWFSDLGFNV
60 70 80 90 100
EVQPVPGTRN KFNMLASTGH GAGGLLLTGH TDTVPFDDGR WTRDPFTLTE
110 120 130 140 150
HDNKLYGLGT ADMKGFFAFI LDALRDVDVT KLKKPLYILA TADEETSMAG
160 170 180 190 200
ARYFSKTTAL RPDCAIIGEP TSLQPIRAHK GHISNVVRVL GQSGHSSDPA
210 220 230 240 250
RGVNAIELMH DAIGHIMQLR DSLKARYHYE AFTVPYPTLN LGHIHGGDAS
260 270 280 290 300
NRICACCELH MDIRPLPGMT LNDLNGLLND ALAPVSERWP GRLTVAELHP
310 320 330 340 350
PIPGYECPPD HQLVEVVEKL LGTKTDVVNY CTEAPFMQTL CPTLVLGPGS
360 370 380
INQAHQPDEY LETRFIKPTR ELITQVVHHF CWH
Length:383
Mass (Da):42,201
Last modified:March 1, 2002 - v1
Checksum:i791A1C0F8A93DA01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA Translation: AAL22959.1
RefSeqiNP_463000.1, NC_003197.2
WP_000800210.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL22959; AAL22959; STM4120
GeneIDi1255647
KEGGistm:STM4120
PATRICifig|99287.12.peg.4342

Similar proteinsi

Entry informationi

Entry nameiARGE_SALTY
AccessioniPrimary (citable) accession number: Q8ZKL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health