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Protein

Acetylornithine deacetylase

Gene

argE

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Displays a broad specificity and can also deacylate substrates such as acetylarginine, acetylhistidine or acetylglutamate semialdehyde.By similarity

Catalytic activityi

N(2)-acetyl-L-ornithine + H2O = acetate + L-ornithine.

Cofactori

Protein has several cofactor binding sites:
  • Zn2+By similarity, Co2+By similarityNote: Binds 2 Zn2+ or Co2+ ions per subunit.By similarity
  • glutathioneBy similarity

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-ornithine from N(2)-acetyl-L-ornithine (linear).
Proteins known to be involved in this subpathway in this organism are:
  1. Acetylornithine deacetylase (argE)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine from N(2)-acetyl-L-ornithine (linear), the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi80 – 801Cobalt or zinc 1By similarity
Active sitei82 – 821By similarity
Metal bindingi112 – 1121Cobalt or zinc 1By similarity
Metal bindingi112 – 1121Cobalt or zinc 2By similarity
Active sitei144 – 1441Proton acceptorBy similarity
Metal bindingi145 – 1451Cobalt or zinc 2By similarity
Metal bindingi169 – 1691Cobalt or zinc 1By similarity
Metal bindingi355 – 3551Cobalt or zinc 2By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

Cobalt, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSENT99287:GCTI-4150-MONOMER.
UniPathwayiUPA00068; UER00110.

Protein family/group databases

MEROPSiM20.974.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine deacetylase (EC:3.5.1.16)
Short name:
AO
Short name:
Acetylornithinase
Alternative name(s):
N-acetylornithinase
Short name:
NAO
Gene namesi
Name:argE
Ordered Locus Names:STM4120
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Acetylornithine deacetylasePRO_0000185249Add
BLAST

Proteomic databases

PaxDbiQ8ZKL9.
PRIDEiQ8ZKL9.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi99287.STM4120.

Structurei

3D structure databases

ProteinModelPortaliQ8ZKL9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20A family. ArgE subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105CWC. Bacteria.
COG0624. LUCA.
HOGENOMiHOG000243769.
KOiK01438.
OMAiGTEAPYL.
OrthoDBiEOG60651W.
PhylomeDBiQ8ZKL9.

Family and domain databases

Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_01108. ArgE.
InterProiIPR010169. AcOrn-deacetyl.
IPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01892. AcOrn-deacetyl. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZKL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNVLPPFIE IYRALIATPS ISATEESLDQ SNASLITLLA GWFSDLGFNV
60 70 80 90 100
EVQPVPGTRN KFNMLASTGH GAGGLLLTGH TDTVPFDDGR WTRDPFTLTE
110 120 130 140 150
HDNKLYGLGT ADMKGFFAFI LDALRDVDVT KLKKPLYILA TADEETSMAG
160 170 180 190 200
ARYFSKTTAL RPDCAIIGEP TSLQPIRAHK GHISNVVRVL GQSGHSSDPA
210 220 230 240 250
RGVNAIELMH DAIGHIMQLR DSLKARYHYE AFTVPYPTLN LGHIHGGDAS
260 270 280 290 300
NRICACCELH MDIRPLPGMT LNDLNGLLND ALAPVSERWP GRLTVAELHP
310 320 330 340 350
PIPGYECPPD HQLVEVVEKL LGTKTDVVNY CTEAPFMQTL CPTLVLGPGS
360 370 380
INQAHQPDEY LETRFIKPTR ELITQVVHHF CWH
Length:383
Mass (Da):42,201
Last modified:March 1, 2002 - v1
Checksum:i791A1C0F8A93DA01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL22959.1.
RefSeqiNP_463000.1. NC_003197.1.
WP_000800210.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL22959; AAL22959; STM4120.
GeneIDi1255647.
KEGGistm:STM4120.
PATRICi32387124. VBISalEnt20916_4342.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL22959.1.
RefSeqiNP_463000.1. NC_003197.1.
WP_000800210.1. NC_003197.1.

3D structure databases

ProteinModelPortaliQ8ZKL9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM4120.

Protein family/group databases

MEROPSiM20.974.

Proteomic databases

PaxDbiQ8ZKL9.
PRIDEiQ8ZKL9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL22959; AAL22959; STM4120.
GeneIDi1255647.
KEGGistm:STM4120.
PATRICi32387124. VBISalEnt20916_4342.

Phylogenomic databases

eggNOGiENOG4105CWC. Bacteria.
COG0624. LUCA.
HOGENOMiHOG000243769.
KOiK01438.
OMAiGTEAPYL.
OrthoDBiEOG60651W.
PhylomeDBiQ8ZKL9.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00110.
BioCyciSENT99287:GCTI-4150-MONOMER.

Family and domain databases

Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_01108. ArgE.
InterProiIPR010169. AcOrn-deacetyl.
IPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01892. AcOrn-deacetyl. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiARGE_SALTY
AccessioniPrimary (citable) accession number: Q8ZKL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2002
Last modified: November 11, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.