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Q8ZKI4

- G6PI_SALTY

UniProt

Q8ZKI4 - G6PI_SALTY

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Protein
Glucose-6-phosphate isomerase
Gene
pgi, atbR, STM4221
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei355 – 3551Proton donor By similarity
Active sitei386 – 3861 By similarity
Active sitei514 – 5141 By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciSENT99287:GCTI-4252-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Synonyms:atbR
Ordered Locus Names:STM4221
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Increases acid tolerance in rpoS mutants, defective in glucose metabolism.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Glucose-6-phosphate isomeraseUniRule annotation
PRO_0000180723Add
BLAST

Proteomic databases

PaxDbiQ8ZKI4.
PRIDEiQ8ZKI4.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi99287.STM4221.

Structurei

3D structure databases

ProteinModelPortaliQ8ZKI4.
SMRiQ8ZKI4. Positions 7-548.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261371.
KOiK01810.
OMAiNCHFVAN.
OrthoDBiEOG64R61J.
PhylomeDBiQ8ZKI4.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZKI4-1 [UniParc]FASTAAdd to Basket

« Hide

MKNINPTQTS AWQALQKHYD EMKDVTIAEL FANDSDRFAK FSATFDDLML    50
VDFSKNRITE ETLAKLQDLA KETDLAGAIK SMFSGEKINR TEDRAVLHVA 100
LRNRSNTPII VDGKDVMPEV NAVLEKMKTF SQAIISGQWK GYTGKAITDV 150
VNIGIGGSDL GPFMVTEALR PYKNHLTMHF VSNVDGTHIA EVLKKVNPET 200
TLFLVASKTF TTQETMTNAH SARDWFLKTA GDEKHVAKHF AALSTNAKAV 250
GEFGIDTANM FEFWDWVGGR YSLWSAIGLS IILSVGFDNF VELLSGAHAM 300
DKHFSTTPAE KNLPILLALI GIWYNNFFGA ETEAILPYDQ YMHRFAAYFQ 350
QGNMESNGKY VDRNGNAVDY QTGPIIWGEP GTNGQHAFYQ LIHQGTKMVP 400
CDFIAPAITH NPLSDHHQKL LSNFFAQTEA LAFGKSREVV EQEYRDQGKD 450
PAQLEHVVPF KVFEGNRPTN SILLREITPF SLGALIALYE HKIFTQGVIL 500
NIFTFDQWGV ELGKQLANRI LPELGDDKAI SSHDSSTNGL INRYKAWRA 549
Length:549
Mass (Da):61,429
Last modified:March 27, 2002 - v1
Checksum:i85642951920C4E6C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL23045.1.
RefSeqiNP_463086.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL23045; AAL23045; STM4221.
GeneIDi1255747.
KEGGistm:STM4221.
PATRICi32387347. VBISalEnt20916_4441.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL23045.1 .
RefSeqi NP_463086.1. NC_003197.1.

3D structure databases

ProteinModelPortali Q8ZKI4.
SMRi Q8ZKI4. Positions 7-548.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM4221.

Proteomic databases

PaxDbi Q8ZKI4.
PRIDEi Q8ZKI4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL23045 ; AAL23045 ; STM4221 .
GeneIDi 1255747.
KEGGi stm:STM4221.
PATRICi 32387347. VBISalEnt20916_4441.

Phylogenomic databases

eggNOGi COG0166.
HOGENOMi HOG000261371.
KOi K01810.
OMAi NCHFVAN.
OrthoDBi EOG64R61J.
PhylomeDBi Q8ZKI4.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .
BioCyci SENT99287:GCTI-4252-MONOMER.

Family and domain databases

Gene3Di 1.10.1390.10. 1 hit.
HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.
  2. "A low pH-inducible, PhoPQ-dependent acid tolerance response protects Salmonella typhimurium against inorganic acid stress."
    Bearson B.L., Wilson L., Foster J.W.
    J. Bacteriol. 180:2409-2417(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiG6PI_SALTY
AccessioniPrimary (citable) accession number: Q8ZKI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: July 9, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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