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Q8ZKI4

- G6PI_SALTY

UniProt

Q8ZKI4 - G6PI_SALTY

Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (27 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei355 – 3551Proton donorUniRule annotation
    Active sitei386 – 3861UniRule annotation
    Active sitei514 – 5141UniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-4252-MONOMER.
    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
    Short name:
    GPIUniRule annotation
    Alternative name(s):
    Phosphoglucose isomeraseUniRule annotation
    Short name:
    PGIUniRule annotation
    Phosphohexose isomeraseUniRule annotation
    Short name:
    PHIUniRule annotation
    Gene namesi
    Name:pgiUniRule annotation
    Synonyms:atbR
    Ordered Locus Names:STM4221
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Disruption phenotypei

    Increases acid tolerance in rpoS mutants, defective in glucose metabolism.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 549549Glucose-6-phosphate isomerasePRO_0000180723Add
    BLAST

    Proteomic databases

    PaxDbiQ8ZKI4.
    PRIDEiQ8ZKI4.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi99287.STM4221.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8ZKI4.
    SMRiQ8ZKI4. Positions 7-548.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0166.
    HOGENOMiHOG000261371.
    KOiK01810.
    OMAiNCHFVAN.
    OrthoDBiEOG64R61J.
    PhylomeDBiQ8ZKI4.

    Family and domain databases

    Gene3Di1.10.1390.10. 1 hit.
    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8ZKI4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNINPTQTS AWQALQKHYD EMKDVTIAEL FANDSDRFAK FSATFDDLML    50
    VDFSKNRITE ETLAKLQDLA KETDLAGAIK SMFSGEKINR TEDRAVLHVA 100
    LRNRSNTPII VDGKDVMPEV NAVLEKMKTF SQAIISGQWK GYTGKAITDV 150
    VNIGIGGSDL GPFMVTEALR PYKNHLTMHF VSNVDGTHIA EVLKKVNPET 200
    TLFLVASKTF TTQETMTNAH SARDWFLKTA GDEKHVAKHF AALSTNAKAV 250
    GEFGIDTANM FEFWDWVGGR YSLWSAIGLS IILSVGFDNF VELLSGAHAM 300
    DKHFSTTPAE KNLPILLALI GIWYNNFFGA ETEAILPYDQ YMHRFAAYFQ 350
    QGNMESNGKY VDRNGNAVDY QTGPIIWGEP GTNGQHAFYQ LIHQGTKMVP 400
    CDFIAPAITH NPLSDHHQKL LSNFFAQTEA LAFGKSREVV EQEYRDQGKD 450
    PAQLEHVVPF KVFEGNRPTN SILLREITPF SLGALIALYE HKIFTQGVIL 500
    NIFTFDQWGV ELGKQLANRI LPELGDDKAI SSHDSSTNGL INRYKAWRA 549
    Length:549
    Mass (Da):61,429
    Last modified:March 27, 2002 - v1
    Checksum:i85642951920C4E6C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL23045.1.
    RefSeqiNP_463086.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL23045; AAL23045; STM4221.
    GeneIDi1255747.
    KEGGistm:STM4221.
    PATRICi32387347. VBISalEnt20916_4441.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL23045.1 .
    RefSeqi NP_463086.1. NC_003197.1.

    3D structure databases

    ProteinModelPortali Q8ZKI4.
    SMRi Q8ZKI4. Positions 7-548.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM4221.

    Proteomic databases

    PaxDbi Q8ZKI4.
    PRIDEi Q8ZKI4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL23045 ; AAL23045 ; STM4221 .
    GeneIDi 1255747.
    KEGGi stm:STM4221.
    PATRICi 32387347. VBISalEnt20916_4441.

    Phylogenomic databases

    eggNOGi COG0166.
    HOGENOMi HOG000261371.
    KOi K01810.
    OMAi NCHFVAN.
    OrthoDBi EOG64R61J.
    PhylomeDBi Q8ZKI4.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    BioCyci SENT99287:GCTI-4252-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1390.10. 1 hit.
    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.
    2. "A low pH-inducible, PhoPQ-dependent acid tolerance response protects Salmonella typhimurium against inorganic acid stress."
      Bearson B.L., Wilson L., Foster J.W.
      J. Bacteriol. 180:2409-2417(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
      Strain: LT2 / SGSC1412 / ATCC 700720.

    Entry informationi

    Entry nameiG6PI_SALTY
    AccessioniPrimary (citable) accession number: Q8ZKI4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: March 27, 2002
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3