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Protein

Putative ribosome biogenesis GTPase RsgA

Gene

rsgA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover.UniRule annotation

Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi297 – 2971ZincUniRule annotation1 Publication
Metal bindingi302 – 3021ZincUniRule annotation1 Publication
Metal bindingi304 – 3041ZincUniRule annotation1 Publication
Metal bindingi310 – 3101ZincUniRule annotation1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi160 – 1634GTPUniRule annotation1 Publication
Nucleotide bindingi214 – 2229GTPUniRule annotation1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

GTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciSENT99287:GCTI-4380-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ribosome biogenesis GTPase RsgAUniRule annotation (EC:3.6.1.-UniRule annotation)
Gene namesi
Name:rsgAUniRule annotation
Synonyms:engC, yjeQ
Ordered Locus Names:STM4349
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350Putative ribosome biogenesis GTPase RsgAPRO_0000008157Add
BLAST

Proteomic databases

PaxDbiQ8ZKB0.
PRIDEiQ8ZKB0.

Interactioni

Subunit structurei

Monomer. Associates with ribosomes.UniRule annotation1 Publication

Protein-protein interaction databases

STRINGi99287.STM4349.

Structurei

Secondary structure

1
350
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi40 – 489Combined sources
Beta strandi51 – 566Combined sources
Beta strandi61 – 666Combined sources
Beta strandi78 – 825Combined sources
Beta strandi95 – 1006Combined sources
Beta strandi106 – 1094Combined sources
Beta strandi117 – 1215Combined sources
Beta strandi125 – 1328Combined sources
Turni133 – 1353Combined sources
Helixi138 – 15114Combined sources
Beta strandi154 – 1607Combined sources
Helixi162 – 1643Combined sources
Helixi167 – 18115Combined sources
Turni182 – 1843Combined sources
Beta strandi187 – 1893Combined sources
Turni192 – 1954Combined sources
Helixi198 – 2058Combined sources
Beta strandi208 – 2136Combined sources
Helixi220 – 2289Combined sources
Beta strandi254 – 2574Combined sources
Beta strandi263 – 2664Combined sources
Helixi268 – 2714Combined sources
Helixi280 – 2856Combined sources
Helixi288 – 2936Combined sources
Beta strandi297 – 2993Combined sources
Beta strandi304 – 3063Combined sources
Helixi311 – 3177Combined sources
Helixi323 – 33614Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RCNX-ray2.25A2-350[»]
ProteinModelPortaliQ8ZKB0.
SMRiQ8ZKB0. Positions 35-337.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8ZKB0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini104 – 273170CP-type GPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi297 – 31014Knuckle-like cysteine clusterUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.UniRule annotation
Contains 1 CP-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105E06. Bacteria.
COG1162. LUCA.
HOGENOMiHOG000006957.
KOiK06949.
OMAiTHIIAAN.
PhylomeDBiQ8ZKB0.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01820. GTPase_RsgA. 1 hit.
InterProiIPR030378. G_CP_dom.
IPR027417. P-loop_NTPase.
IPR004881. Ribosome_biogen_GTPase_RsgA.
IPR010914. RsgA_GTPase_dom.
[Graphical view]
PfamiPF03193. DUF258. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00157. TIGR00157. 1 hit.
PROSITEiPS50936. ENGC_GTPASE. 1 hit.
PS51721. G_CP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZKB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKNKLSKGQ QRRVNANHQR RLKTSAEKAD YDDNLFGEPA EGIVISRFGM
60 70 80 90 100
HADVESADGE VHRCNIRRTI RSLVTGDRVV WRPGKAAAEG VNVKGIVEAV
110 120 130 140 150
HERTSVLTRP DFYDGVKPIA ANIDQIVIVS AILPELSLNI IDRYLVGCET
160 170 180 190 200
LQVEPLIVLN KIDLLDDEGM DFVNEQMDIY RNIGYRVLMV SSHTQDGLKP
210 220 230 240 250
LEEALTGRIS IFAGQSGVGK SSLLNALLGL QNEILTNDVS NVSGLGQHTT
260 270 280 290 300
TAARLYHFPH GGDVIDSPGV REFGLWHLEP EQITQGFVEF HDYLGHCKYR
310 320 330 340 350
DCKHDADPGC AIREAVENGA IAETRFENYH RILESMAQVK TRKNFSDTDD
Length:350
Mass (Da):38,948
Last modified:October 31, 2003 - v2
Checksum:iFC0E9580E7028405
GO

Sequence cautioni

The sequence AAL23172 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL23172.1. Different initiation.
RefSeqiNP_463213.2. NC_003197.1.
WP_000041945.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL23172; AAL23172; STM4349.
GeneIDi1255875.
KEGGistm:STM4349.
PATRICi32387619. VBISalEnt20916_4576.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL23172.1. Different initiation.
RefSeqiNP_463213.2. NC_003197.1.
WP_000041945.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RCNX-ray2.25A2-350[»]
ProteinModelPortaliQ8ZKB0.
SMRiQ8ZKB0. Positions 35-337.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM4349.

Proteomic databases

PaxDbiQ8ZKB0.
PRIDEiQ8ZKB0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL23172; AAL23172; STM4349.
GeneIDi1255875.
KEGGistm:STM4349.
PATRICi32387619. VBISalEnt20916_4576.

Phylogenomic databases

eggNOGiENOG4105E06. Bacteria.
COG1162. LUCA.
HOGENOMiHOG000006957.
KOiK06949.
OMAiTHIIAAN.
PhylomeDBiQ8ZKB0.

Enzyme and pathway databases

BioCyciSENT99287:GCTI-4380-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ8ZKB0.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01820. GTPase_RsgA. 1 hit.
InterProiIPR030378. G_CP_dom.
IPR027417. P-loop_NTPase.
IPR004881. Ribosome_biogen_GTPase_RsgA.
IPR010914. RsgA_GTPase_dom.
[Graphical view]
PfamiPF03193. DUF258. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00157. TIGR00157. 1 hit.
PROSITEiPS50936. ENGC_GTPASE. 1 hit.
PS51721. G_CP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRSGA_SALTY
AccessioniPrimary (citable) accession number: Q8ZKB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 31, 2003
Last modified: September 7, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.