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Protein

Small ribosomal subunit biogenesis GTPase RsgA

Gene

rsgA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.UniRule annotation

Cofactori

Zn2+UniRule annotation1 PublicationNote: Binds 1 zinc ion per subunit.UniRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi297ZincUniRule annotation1 Publication1
Metal bindingi302ZincUniRule annotation1 Publication1
Metal bindingi304Zinc; via pros nitrogenUniRule annotation1 Publication1
Metal bindingi310ZincUniRule annotation1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi160 – 163GTPUniRule annotation1 Publication4
Nucleotide bindingi214 – 222GTPUniRule annotation1 Publication9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, RNA-binding, rRNA-binding
Biological processRibosome biogenesis
LigandGTP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Small ribosomal subunit biogenesis GTPase RsgAUniRule annotation (EC:3.6.1.-UniRule annotation)
Gene namesi
Name:rsgAUniRule annotation
Synonyms:engC, yjeQ
Ordered Locus Names:STM4349
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000081571 – 350Small ribosomal subunit biogenesis GTPase RsgAAdd BLAST350

Proteomic databases

PaxDbiQ8ZKB0.
PRIDEiQ8ZKB0.

Interactioni

Subunit structurei

Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.UniRule annotation1 Publication

Protein-protein interaction databases

STRINGi99287.STM4349.

Structurei

Secondary structure

1350
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi40 – 48Combined sources9
Beta strandi51 – 56Combined sources6
Beta strandi61 – 66Combined sources6
Beta strandi78 – 82Combined sources5
Beta strandi95 – 100Combined sources6
Beta strandi106 – 109Combined sources4
Beta strandi117 – 121Combined sources5
Beta strandi125 – 132Combined sources8
Turni133 – 135Combined sources3
Helixi138 – 151Combined sources14
Beta strandi154 – 160Combined sources7
Helixi162 – 164Combined sources3
Helixi167 – 181Combined sources15
Turni182 – 184Combined sources3
Beta strandi187 – 189Combined sources3
Turni192 – 195Combined sources4
Helixi198 – 205Combined sources8
Beta strandi208 – 213Combined sources6
Helixi220 – 228Combined sources9
Beta strandi254 – 257Combined sources4
Beta strandi263 – 266Combined sources4
Helixi268 – 271Combined sources4
Helixi280 – 285Combined sources6
Helixi288 – 293Combined sources6
Beta strandi297 – 299Combined sources3
Beta strandi304 – 306Combined sources3
Helixi311 – 317Combined sources7
Helixi323 – 336Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RCNX-ray2.25A2-350[»]
ProteinModelPortaliQ8ZKB0.
SMRiQ8ZKB0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8ZKB0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 273CP-type GPROSITE-ProRule annotationAdd BLAST170

Sequence similaritiesi

Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E06. Bacteria.
COG1162. LUCA.
HOGENOMiHOG000006957.
OMAiFRDCKHL.
PhylomeDBiQ8ZKB0.

Family and domain databases

CDDicd01854. YjeQ_EngC. 1 hit.
HAMAPiMF_01820. GTPase_RsgA. 1 hit.
InterProiView protein in InterPro
IPR030378. G_CP_dom.
IPR027417. P-loop_NTPase.
IPR004881. Ribosome_biogen_GTPase_RsgA.
IPR010914. RsgA_GTPase_dom.
PANTHERiPTHR32120. PTHR32120. 1 hit.
PfamiView protein in Pfam
PF03193. RsgA_GTPase. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00157. TIGR00157. 1 hit.
PROSITEiView protein in PROSITE
PS50936. ENGC_GTPASE. 1 hit.
PS51721. G_CP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZKB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKNKLSKGQ QRRVNANHQR RLKTSAEKAD YDDNLFGEPA EGIVISRFGM
60 70 80 90 100
HADVESADGE VHRCNIRRTI RSLVTGDRVV WRPGKAAAEG VNVKGIVEAV
110 120 130 140 150
HERTSVLTRP DFYDGVKPIA ANIDQIVIVS AILPELSLNI IDRYLVGCET
160 170 180 190 200
LQVEPLIVLN KIDLLDDEGM DFVNEQMDIY RNIGYRVLMV SSHTQDGLKP
210 220 230 240 250
LEEALTGRIS IFAGQSGVGK SSLLNALLGL QNEILTNDVS NVSGLGQHTT
260 270 280 290 300
TAARLYHFPH GGDVIDSPGV REFGLWHLEP EQITQGFVEF HDYLGHCKYR
310 320 330 340 350
DCKHDADPGC AIREAVENGA IAETRFENYH RILESMAQVK TRKNFSDTDD
Length:350
Mass (Da):38,948
Last modified:October 31, 2003 - v2
Checksum:iFC0E9580E7028405
GO

Sequence cautioni

The sequence AAL23172 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL23172.1. Different initiation.
RefSeqiNP_463213.3. NC_003197.2.

Genome annotation databases

EnsemblBacteriaiAAL23172; AAL23172; STM4349.
GeneIDi1255875.
PATRICifig|99287.12.peg.4576.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL23172.1. Different initiation.
RefSeqiNP_463213.3. NC_003197.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RCNX-ray2.25A2-350[»]
ProteinModelPortaliQ8ZKB0.
SMRiQ8ZKB0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM4349.

Proteomic databases

PaxDbiQ8ZKB0.
PRIDEiQ8ZKB0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL23172; AAL23172; STM4349.
GeneIDi1255875.
PATRICifig|99287.12.peg.4576.

Phylogenomic databases

eggNOGiENOG4105E06. Bacteria.
COG1162. LUCA.
HOGENOMiHOG000006957.
OMAiFRDCKHL.
PhylomeDBiQ8ZKB0.

Miscellaneous databases

EvolutionaryTraceiQ8ZKB0.

Family and domain databases

CDDicd01854. YjeQ_EngC. 1 hit.
HAMAPiMF_01820. GTPase_RsgA. 1 hit.
InterProiView protein in InterPro
IPR030378. G_CP_dom.
IPR027417. P-loop_NTPase.
IPR004881. Ribosome_biogen_GTPase_RsgA.
IPR010914. RsgA_GTPase_dom.
PANTHERiPTHR32120. PTHR32120. 1 hit.
PfamiView protein in Pfam
PF03193. RsgA_GTPase. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00157. TIGR00157. 1 hit.
PROSITEiView protein in PROSITE
PS50936. ENGC_GTPASE. 1 hit.
PS51721. G_CP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRSGA_SALTY
AccessioniPrimary (citable) accession number: Q8ZKB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 31, 2003
Last modified: June 7, 2017
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.