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Q8ZJQ2

- KGUA_YERPE

UniProt

Q8ZJQ2 - KGUA_YERPE

Protein

Guanylate kinase

Gene

gmk

Organism
Yersinia pestis
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Essential for recycling GMP and indirectly, cGMP.UniRule annotation

    Catalytic activityi

    ATP + GMP = ADP + GDP.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 188ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. guanylate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. purine nucleotide metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYPES214092:GKDD-45-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanylate kinaseUniRule annotation (EC:2.7.4.8UniRule annotation)
    Alternative name(s):
    GMP kinaseUniRule annotation
    Gene namesi
    Name:gmkUniRule annotation
    Ordered Locus Names:YPO0040, y0101, YP_0041
    OrganismiYersinia pestis
    Taxonomic identifieri632 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 207207Guanylate kinasePRO_0000170647Add
    BLAST

    Proteomic databases

    PRIDEiQ8ZJQ2.

    Interactioni

    Protein-protein interaction databases

    STRINGi214092.YPO0040.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8ZJQ2.
    SMRiQ8ZJQ2. Positions 3-207.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 184181Guanylate kinase-likeUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the guanylate kinase family.UniRule annotation
    Contains 1 guanylate kinase-like domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0194.
    HOGENOMiHOG000037638.
    KOiK00942.
    OMAiMSHYNEY.
    OrthoDBiEOG6CP410.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_00328. Guanylate_kinase.
    InterProiIPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR017665. Guanylate_kinase.
    IPR020590. Guanylate_kinase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00625. Guanylate_kin. 1 hit.
    [Graphical view]
    SMARTiSM00072. GuKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
    PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8ZJQ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVQGTLYIVS APSGAGKSSL IQALLKTQPL YDTQVSISHT TRAKRPGENH    50
    GEHYFFVSEK EFCQMIDDDA FLEHAKVFEN YYGTSRLAIE QVLATGVDVF 100
    LDIDWQGAQQ IRAKMPTARS IFILPPSKTE LDRRLRGRGQ DSEEVIAKRM 150
    EQAVAEMAHY AEYDYLIVND DFNLALSDLK TIIRAERLRL GRQKQRHDAL 200
    ISKLLAD 207
    Length:207
    Mass (Da):23,504
    Last modified:March 1, 2002 - v1
    Checksum:i01FDCD618EFED91E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL18730.1.
    AE009952 Genomic DNA. Translation: AAM83695.1.
    AE017042 Genomic DNA. Translation: AAS60322.1.
    PIRiAI0005.
    RefSeqiNP_667444.1. NC_004088.1.
    NP_991445.1. NC_005810.1.
    YP_002345136.1. NC_003143.1.

    Genome annotation databases

    EnsemblBacteriaiAAM83695; AAM83695; y0101.
    AAS60322; AAS60322; YP_0041.
    GeneIDi1145048.
    1172890.
    2765945.
    KEGGiype:YPO0040.
    ypk:y0101.
    ypm:YP_0041.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL18730.1 .
    AE009952 Genomic DNA. Translation: AAM83695.1 .
    AE017042 Genomic DNA. Translation: AAS60322.1 .
    PIRi AI0005.
    RefSeqi NP_667444.1. NC_004088.1.
    NP_991445.1. NC_005810.1.
    YP_002345136.1. NC_003143.1.

    3D structure databases

    ProteinModelPortali Q8ZJQ2.
    SMRi Q8ZJQ2. Positions 3-207.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 214092.YPO0040.

    Proteomic databases

    PRIDEi Q8ZJQ2.

    Protocols and materials databases

    DNASUi 1145048.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM83695 ; AAM83695 ; y0101 .
    AAS60322 ; AAS60322 ; YP_0041 .
    GeneIDi 1145048.
    1172890.
    2765945.
    KEGGi ype:YPO0040.
    ypk:y0101.
    ypm:YP_0041.

    Phylogenomic databases

    eggNOGi COG0194.
    HOGENOMi HOG000037638.
    KOi K00942.
    OMAi MSHYNEY.
    OrthoDBi EOG6CP410.

    Enzyme and pathway databases

    BioCyci YPES214092:GKDD-45-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_00328. Guanylate_kinase.
    InterProi IPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR017665. Guanylate_kinase.
    IPR020590. Guanylate_kinase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00625. Guanylate_kin. 1 hit.
    [Graphical view ]
    SMARTi SM00072. GuKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR03263. guanyl_kin. 1 hit.
    PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CO-92 / Biovar Orientalis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KIM10+ / Biovar Mediaevalis.
    3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
      Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
      , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
      DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 91001 / Biovar Mediaevalis.

    Entry informationi

    Entry nameiKGUA_YERPE
    AccessioniPrimary (citable) accession number: Q8ZJQ2
    Secondary accession number(s): Q0WKQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3