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Q8ZJN0 (GPMI_YERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Short name=BPG-independent PGAM
Short name=Phosphoglyceromutase
Short name=iPGM
EC=5.4.2.1
Gene names
Name:gpmI
Ordered Locus Names:YPO0064, y0077, YP_0064
OrganismYersinia pestis [Reference proteome] [HAMAP]
Taxonomic identifier632 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length515 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity. HAMAP-Rule MF_01038

Catalytic activity

2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP-Rule MF_01038

Cofactor

Binds 2 manganese ions per subunit By similarity.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP-Rule MF_01038

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the BPG-independent phosphoglycerate mutase family.

Ontologies

Keywords
   Biological processGlycolysis
   LigandManganese
Metal-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular_function2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity

Inferred from electronic annotation. Source: HAMAP

manganese ion binding

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 5155152,3-bisphosphoglycerate-independent phosphoglycerate mutase HAMAP-Rule MF_01038
PRO_0000212234

Sites

Active site641Phosphoserine intermediate By similarity
Metal binding141Manganese 2 By similarity
Metal binding641Manganese 2 By similarity
Metal binding4041Manganese 1 By similarity
Metal binding4081Manganese 1 By similarity
Metal binding4451Manganese 2 By similarity
Metal binding4461Manganese 2 By similarity
Metal binding4641Manganese 1 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8ZJN0 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 62DD23480ADBE39D

FASTA51556,168
        10         20         30         40         50         60 
MSSTKKPLVL TILDGYGHRE EQQDNAILNA KTPVMDVLWQ QQPHTLIAAS GLDVGLPDGQ 

        70         80         90        100        110        120 
MGNSEVGHVN LGAGRIVYQD LTRLDKEIKE GDFFTNPTLT AAVDNAVKTG KAVHIMGLLS 

       130        140        150        160        170        180 
AGGVHSHEDH IMAMVELAAK RGATAIYLHA FLDGRDTPPR SAESSLKRFT AKFAELGNGR 

       190        200        210        220        230        240 
IASIIGRYYA MDRDNRWDRV QLAYDLLTQA KGEFTADNAV AGLQAAYARG ENDEFVKPTV 

       250        260        270        280        290        300 
IQATGEADAA MNEGDTLIFM NFRADRARQI TRTFVNAEFD GFKRDKVVNF GDFIMLTEYA 

       310        320        330        340        350        360 
ADIKVACAYP PASLTNTFGE WLMKHDKTQL RISETEKYAH VTFFYNGGVE EPFKGEDRIL 

       370        380        390        400        410        420 
INSPKVATYD LQPEMSSAEL TEKLVSAIGS GKYDVIICNY PNGDMVGHTG DYDAAVKAVE 

       430        440        450        460        470        480 
TLDNCIEQVV AAVKAADGQL LITADHGNAE QMRDPATGQA HTAHTSLPVP LIYVGNKAVK 

       490        500        510 
AVEGGKLSDI APTMLSLMEM EIPQEMTGKP LFIVE

« Hide

References

[1]"Genome sequence of Yersinia pestis, the causative agent of plague."
Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. expand/collapse author list , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.
Nature 413:523-527(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CO-92 / Biovar Orientalis.
[2]"Genome sequence of Yersinia pestis KIM."
Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. expand/collapse author list , Matson J.S., Blattner F.R., Perry R.D.
J. Bacteriol. 184:4601-4611(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KIM10+ / Biovar Mediaevalis.
[3]"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. expand/collapse author list , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 91001 / Biovar Mediaevalis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL590842 Genomic DNA. Translation: CAL18753.1.
AE009952 Genomic DNA. Translation: AAM83672.1.
AE017042 Genomic DNA. Translation: AAS60344.1.
PIRAH0008.
RefSeqNP_667421.1. NC_004088.1.
NP_991467.1. NC_005810.1.
YP_002345158.1. NC_003143.1.

3D structure databases

ProteinModelPortalQ8ZJN0.
ModBaseSearch...

Protein-protein interaction databases

STRING214092.YPO0064.

Proteomic databases

PRIDEQ8ZJN0.

Protocols and materials databases

DNASU1145024.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM83672; AAM83672; y0077.
AAS60344; AAS60344; YP_0064.
GeneID1145024.
1172913.
2766274.
KEGGype:YPO0064.
ypk:y0077.
ypm:YP_0064.

Phylogenomic databases

eggNOGCOG0696.
HOGENOMHOG000223664.
KOK15633.
OMANAEQMTD.
ProtClustDBPRK05434.

Enzyme and pathway databases

UniPathwayUPA00109; UER00186.

Family and domain databases

Gene3D3.40.1450.10. 1 hit.
3.40.720.10. 2 hits.
HAMAPMF_01038. GpmI.
InterProIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR011258. BPG-indep_PGM_N.
IPR006124. Metalloenzyme.
IPR005995. Pgm_bpd_ind.
[Graphical view]
PfamPF06415. iPGM_N. 1 hit.
PF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFPIRSF001492. IPGAM. 1 hit.
SUPFAMSSF53649. Alkaline_phosphatase_core. 1 hit.
SSF64158. BPG-indep_PGM_N. 1 hit.
TIGRFAMsTIGR01307. pgm_bpd_ind. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGPMI_YERPE
AccessionPrimary (citable) accession number: Q8ZJN0
Secondary accession number(s): Q0WKN0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: March 1, 2002
Last modified: May 1, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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