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Protein

Glutathione-regulated potassium-efflux system ancillary protein KefG

Gene

kefG

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefB.UniRule annotation

Catalytic activityi

NAD(P)H + a quinone = NAD(P)+ + a hydroquinone.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciYPES214092:GKDD-187-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione-regulated potassium-efflux system ancillary protein KefGUniRule annotation
Alternative name(s):
Putative quinone oxidoreductase KefGUniRule annotation (EC:1.6.5.2UniRule annotation)
Gene namesi
Name:kefGUniRule annotation
Ordered Locus Names:YPO0190, y3971, YP_0188
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183Glutathione-regulated potassium-efflux system ancillary protein KefGPRO_0000071650Add
BLAST

Interactioni

Subunit structurei

Interacts with KefB.UniRule annotation

Protein-protein interaction databases

IntActiQ8ZJC5. 1 interaction.
STRINGi187410.y3971.

Structurei

3D structure databases

ProteinModelPortaliQ8ZJC5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD(P)H dehydrogenase (quinone) family. KefG subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108K2R. Bacteria.
COG2249. LUCA.
HOGENOMiHOG000149972.
KOiK11748.
OMAiALAGKYW.
OrthoDBiEOG628F94.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
HAMAPiMF_01415. K_H_efflux_KefG.
InterProiIPR003680. Flavodoxin_fold.
IPR029039. Flavoprotein-like_dom.
IPR023947. K_H_efflux_KefG.
[Graphical view]
PfamiPF02525. Flavodoxin_2. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZJC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLQPPKVLL LYAHPESQDS VANRVLLQPV QQLEHVTVHD LYAHYPDFFI
60 70 80 90 100
DIHHEQQLLR DHQVIVFQHP LYTYSCPALL KEWLDRVLAR GFANGVGGHA
110 120 130 140 150
LTGKHWRSVI TTGEQEGTYR IGGYNRYPME DILRPFELTA AMCHMHWINP
160 170 180
MIIYWARRQK PETLASHAQA YVQWLQSPLT RGL
Length:183
Mass (Da):21,332
Last modified:March 1, 2002 - v1
Checksum:iA31EBB7E44A2B567
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL18874.1.
AE009952 Genomic DNA. Translation: AAM87515.1.
AE017042 Genomic DNA. Translation: AAS60464.1.
PIRiAI0023.
RefSeqiYP_002345272.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM87515; AAM87515; y3971.
AAS60464; AAS60464; YP_0188.
GeneIDi1173034.
KEGGiype:YPO0190.
ypk:y3971.
ypm:YP_0188.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL18874.1.
AE009952 Genomic DNA. Translation: AAM87515.1.
AE017042 Genomic DNA. Translation: AAS60464.1.
PIRiAI0023.
RefSeqiYP_002345272.1. NC_003143.1.

3D structure databases

ProteinModelPortaliQ8ZJC5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8ZJC5. 1 interaction.
STRINGi187410.y3971.

Protocols and materials databases

DNASUi1148918.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM87515; AAM87515; y3971.
AAS60464; AAS60464; YP_0188.
GeneIDi1173034.
KEGGiype:YPO0190.
ypk:y3971.
ypm:YP_0188.

Phylogenomic databases

eggNOGiENOG4108K2R. Bacteria.
COG2249. LUCA.
HOGENOMiHOG000149972.
KOiK11748.
OMAiALAGKYW.
OrthoDBiEOG628F94.

Enzyme and pathway databases

BioCyciYPES214092:GKDD-187-MONOMER.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
HAMAPiMF_01415. K_H_efflux_KefG.
InterProiIPR003680. Flavodoxin_fold.
IPR029039. Flavoprotein-like_dom.
IPR023947. K_H_efflux_KefG.
[Graphical view]
PfamiPF02525. Flavodoxin_2. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiKEFG_YERPE
AccessioniPrimary (citable) accession number: Q8ZJC5
Secondary accession number(s): Q0WKB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: March 1, 2002
Last modified: January 20, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.